P53762

PR
Gene name
Arnt
Protein name
Aryl hydrocarbon receptor nuclear translocator
Names
ARNT protein, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:11863
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

44-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

18 structures for P53762

Entry ID Method Resolution Chain Position Source
4ZP4 X-ray 235 A A/C 82-464 PDB
4ZPH X-ray 280 A A/C 82-464 PDB
4ZPK X-ray 360 A A 82-464 PDB
4ZPR X-ray 390 A A 82-464 PDB
4ZQD X-ray 287 A A/C 82-464 PDB
5NJ8 X-ray 330 A B/D 84-345 PDB
5SY5 X-ray 320 A A/C/E 82-464 PDB
5SY7 X-ray 420 A A 82-464 PDB
6E3S X-ray 300 A A 81-464 PDB
6E3T X-ray 300 A A 81-464 PDB
6E3U X-ray 285 A A 81-464 PDB
7V7L X-ray 230 A A 81-464 PDB
7V7W X-ray 251 A A 81-464 PDB
7VNI X-ray 200 A C/D 358-466 PDB
7W80 X-ray 275 A A 81-464 PDB
7XHV X-ray 400 A A 82-360 PDB
7XI4 X-ray 471 A A 82-464 PDB
AF-P53762-F1 Predicted AlphaFoldDB

23 variants for P53762

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3393373044 5 T>A No EVA
rs3388647484 19 P>L No EVA
rs33119805 37 V>L No EVA
rs8251887 41 I>V No EVA
rs243287530 67 M>I No EVA
rs3388644607 98 E>V No EVA
rs3393164623 152 G>L* No EVA
rs3388652581 393 G>E No EVA
rs3388647436 418 L>I No EVA
rs3388647455 447 Q>H No EVA
rs3717575 497 G>E No EVA
rs33122907 508 H>Q No EVA
rs3388645027 508 H>R No EVA
rs3388649819 535 S>R No EVA
rs3388641345 540 H>R No EVA
rs3388648715 540 H>Y No EVA
rs3388648678 541 S>G No EVA
rs8252009 618 S>F No EVA
rs8252008 619 S>F No EVA
rs8252007 634 A>V No EVA
rs242830581 651 A>T No EVA
rs3402644551 669 V>L No EVA
rs3388637130 685 G>D No EVA

No associated diseases with P53762

No regional properties for P53762

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P53762

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
aryl hydrocarbon receptor complex A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

12 GO annotations of molecular function

Name Definition
aryl hydrocarbon receptor binding Binding to an aryl hydrocarbon receptor.
cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein-containing complex binding Binding to a macromolecular complex.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

11 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
embryonic placenta development The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
positive regulation of protein sumoylation Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of vascular endothelial growth factor production Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription from RNA polymerase II promoter in response to oxidative stress Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00327 ARNTL Aryl hydrocarbon receptor nuclear translocator-like protein 1 Homo sapiens (Human) PR
P27540 ARNT Aryl hydrocarbon receptor nuclear translocator Homo sapiens (Human) PR
10 20 30 40 50 60
MAATTANPEM TSDVPSLGPT IASGNPGPGI QGGGAVVQRA IKRRSGLDFD DEVEVNTKFL
70 80 90 100 110 120
RCDDDQMCND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS
130 140 150 160 170 180
ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS
190 200 210 220 230 240
CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRVLDLK
250 260 270 280 290 300
TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG TSSVDPVSMN RLSFLRNRCR NGLGSVKEGE
310 320 330 340 350 360
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN CTDMSNICQP
370 380 390 400 410 420
TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC HPEDQQLLRD SFQQVVKLKG
430 440 450 460 470 480
QVLSVMFRFR SKTREWLWMR TSSFTFQNPY SDEIEYIICT NTNVKNSSQE PRPTLSNTIP
490 500 510 520 530 540
RSQLGPTANL SLEMGTGQLP SRQQQQQHTE LDMVPGRDGL ASYNHSQVSV QPVASAGSEH
550 560 570 580 590 600
SKPLEKSEGL FAQDRDPRFP EIYPSITADQ SKGISSSTVP ATQQLFSQGS SFPPNPRPAE
610 620 630 640 650 660
NFRNSGLTPP VTIVQPSSSA GQILAQISRH SNPAQGSAPT WTSSSRPGFA AQQVPTQATA
670 680 690 700 710 720
KTRSSQFGVN NFQTSSSFSA MSLPGAPTAS SGTAAYPALP NRGSNFPPET GQTTGQFQAR
730 740 750 760 770 780
TAEGVGVWPQ WQGQQPHHRS SSSEQHVQQT QAQAPSQPEV FQEMLSMLGD QSNTYNNEEF
790
PDLTMFPPFS E