P53721
Gene name |
RCF2 (AIM38, YNR018W, N3185) |
Protein name |
Respiratory supercomplex factor 2, mitochondrial |
Names |
Altered inheritance of mitochondria protein 38 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNR018W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P53721
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6LUL | NMR | - | A/B | 1-224 | PDB |
| 6T0B | EM | 280 A | m/z | 1-224 | PDB |
| 6T15 | EM | 329 A | m | 1-224 | PDB |
| AF-P53721-F1 | Predicted | AlphaFoldDB |
3 variants for P53721
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-664501 | 77 | N>S | No | SGRP | |
| s14-664686 | 139 | P>S | No | SGRP | |
| s14-664750 | 160 | G>A | No | SGRP |
No associated diseases with P53721
1 regional properties for P53721
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Hypoxia induced protein, domain | 89 - 180 | IPR007667 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial respirasome | The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial cytochrome c oxidase assembly | The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. |
| regulation of proton transport | Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKILTQDEIE | AHRSHTLKGG | IEGALAGFAI | SAIIFKVLPR | RYPKFKPSTL | TWSIKTALWI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPPTVLTAIC | AEEASNNFDA | TMYGSGSSSE | DALDEHRRWK | SLSTKDKFVE | GLSNNKYKII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGAWAASLYG | SWVIVNKDPI | MTKAQKIVQA | RMYAQFITVG | LLLASVGLSM | YENKLHPNKQ |
| 190 | 200 | 210 | 220 | ||
| KVNEMRRWEN | ALRVAEEEER | LEKEGRRTGY | VSNEERINSK | IFKS |