P53603

PR
Gene name
FTCD
Protein name
Formimidoyltransferase-cyclodeaminase
Names
Formiminotransferase-cyclodeaminase, FTCD
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397517
EC number
2.1.2.5: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

308-379 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P53603

Entry ID Method Resolution Chain Position Source
1QD1 X-ray 170 A A/B 2-326 PDB
AF-P53603-F1 Predicted AlphaFoldDB

No variants for P53603

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P53603

No associated diseases with P53603

4 regional properties for P53603

Type Name Position InterPro Accession
domain Formiminotransferase catalytic domain 1 - 309 IPR004227
domain Cyclodeaminase/cyclohydrolase 340 - 519 IPR007044
domain Formiminotransferase, N-terminal subdomain 3 - 180 IPR012886
domain Formiminotransferase, C-terminal subdomain 181 - 325 IPR013802

Functions

Description
EC Number 2.1.2.5 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm, cytosol
  • Golgi apparatus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • More abundantly located around the mother centriole
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

3 GO annotations of molecular function

Name Definition
folic acid binding Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
formimidoyltetrahydrofolate cyclodeaminase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+).
glutamate formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.

3 GO annotations of biological process

Name Definition
histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
histidine catabolic process to glutamate and formamide The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide.
histidine catabolic process to glutamate and formate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQLVECVPN FSEGKNQEVI DAISRAVAQT PGCVLLDVDS GPSTNRTVYT FVGRPEDVVE
70 80 90 100 110 120
GALNAARAAY QLIDMSRHHG EHPRMGALDV CPFIPVRGVT MDECVRCAQA FGQRLAEELG
130 140 150 160 170 180
VPVYLYGEAA RTAGRQSLPA LRAGEYEALP EKLKQAEWAP DFGPSAFVPS WGATVAGARK
190 200 210 220 230 240
FLLAFNINLL STREQAHRIA LDLREQGRGK DQPGRLKKVQ AIGWYLDEKN LAQVSTNLLD
250 260 270 280 290 300
FEVTGLHTVF EETCREAQEL SLPVVGSQLV GLVPLKALLD AAAFYCEKEN LFLLQDEHRI
310 320 330 340 350 360
RLVVNRLGLD SLAPFKPKER IIEYLVPEAG PEQSLLHKPL RTFVREVGSR SAAPGAGSVA
370 380 390 400 410 420
AATAAMGAAL ASMVGLMTYG RRQFEHLDAT MRRLIPPFHA ASAKLTSLVD ADARAFEAYL
430 440 450 460 470 480
KAMKLPKDTP EDKDRRAAAL QEGLRQAVAV PLALAETVAS LWPALQELAL CGNLACRSDL
490 500 510 520 530 540
QVAAKALETG VFGAYFNVLI NLKDVTDDAF KAQVRQRISS LLQEAKTQAA LVLDRLEARQ
A