P53588

PR
Gene name
suca-1
Protein name
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
ATP-specific succinyl-CoA synthetase subunit beta, A-SCS, Succinyl-CoA synthetase beta-A chain, SCS-betaA
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F47B10.1
EC number
6.2.1.5: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53588

Entry ID Method Resolution Chain Position Source
AF-P53588-F1 Predicted AlphaFoldDB

No variants for P53588

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P53588

No associated diseases with P53588

4 regional properties for P53588

Type Name Position InterPro Accession
domain ATP-citrate lyase/succinyl-CoA ligase 292 - 413 IPR005811
domain ATP-grasp fold 32 - 284 IPR011761
domain ATP-grasp fold, succinyl-CoA synthetase-type 26 - 232 IPR013650
conserved_site Succinyl-CoA synthetase, beta subunit, conserved site 287 - 312 IPR017866

Functions

Description
EC Number 6.2.1.5 Acid--thiol ligases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
succinate-CoA ligase complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
succinate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate.

2 GO annotations of biological process

Name Definition
succinyl-CoA metabolic process The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIGRISQPLL NTSQKFMAPA ARTLMLHEHH GMKILQNYEI KVPPFGVAQD AETAFSEAKR
70 80 90 100 110 120
IGGKDYVVKA QVLAGGRGKG RFSSGLQGGV QIVFTPDEVK QKAGMMIGAN LITKQTDHRG
130 140 150 160 170 180
KKCEEVMVCK RLFTRREYYF SITLDRNTNG PIVIASSQGG VNIEEVAATN PDAIVKMPID
190 200 210 220 230 240
VNVGITKELA HEIAVKMGFS KDCEQQASEI IEKLYQMFKG SDATLVEINP MAEDVNGDVY
250 260 270 280 290 300
CMDCKLLLDS NAEFRQAKLF DLKDKKQEDE LEIRAAAANL NYIRLDGTIG CMVNGAGLAM
310 320 330 340 350 360
ATMDIIKLHG GEPANFLDVG GGATVEQVTE AFKIITADKD KVSAILVNIF GGIMRCDVIA
370 380 390 400 410 420
QGIIQAAREL DLKIPIVVRL QGTKVEDAKA LIATSQLRIL PCDNLDEAAK MVVKLSNIVD
430
LARATNVDVK FELSI