Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53490
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53490-F1 | Predicted | AlphaFoldDB |
No variants for P53490
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P53490 | |||||
No associated diseases with P53490
1 regional properties for P53490
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Actin/actin-like conserved site | 119 - 131 | IPR020902 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Arp2/3 protein complex | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| Arp2/3 complex-mediated actin nucleation | The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| response to chemical | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRSGLPAVV | IDNGTGYTKM | GYAGNTEPQY | IIPTAIATKG | IAEDPRCRAR | RWWCPWAAGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NIADLDFFIG | DEAYENSKVY | QITMPVRHGQ | VENWTHMEQF | WEHCIFKYLR | CEPEDHHFLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEPPLNAPEN | REYTAEIMFE | TFNVPGLYIA | VQAVLALAAS | WTSKQVTEKT | LTGTVIDSGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVTHVIPVAE | GYVIGSSIKH | IPLAGRDITN | FVLQLLRERN | EKIPPAETLE | VAKRIKETFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YVCPDIVKEF | KKYDTEPDKW | FKTYEGIESV | GKKPYNVDVG | YERFLGPEIF | FNPEIFSSDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTPLPKVVDE | TIQSCPIDTR | RGLYKNIVLS | GGSTMFKDFG | KRLQRDIKRA | VDYRIKRSEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSQGRIKSKA | VDVKVISHHM | QRFAVWFGGS | MLASTPEFYK | VCHTKQQYDE | VGPSICRHNP |
| VFGAMTM |