P53389
Gene name |
HOL1 (YNR055C, N3494) |
Protein name |
Protein HOL1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNR055C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53389
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53389-F1 | Predicted | AlphaFoldDB |
4 variants for P53389
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-729512 | 226 | V>M | No | SGRP | |
| s14-729499 | 230 | G>A | No | SGRP | |
| s14-729316 | 291 | A>D | No | SGRP | |
| s14-728672 | 506 | P>S | No | SGRP |
No associated diseases with P53389
No regional properties for P53389
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53389 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| alcohol transmembrane transporter activity | Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. |
| inorganic cation transmembrane transporter activity | Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cation transport | The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| organic hydroxy compound transport | The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKYTNRDHP | DYIPGTFNIY | SSQNLENGII | YESKLKKTSS | GVVLIPQPSY | SPNDPLNWSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WRKLAHFGLM | AFITAFTAAT | SNDAGAAQDS | LNEIYGISYD | SMNTGAGVLF | LGIGWSTLFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APFANLYGRK | ITYIVCTTLG | LFGALWFALA | KRTSDTIWSQ | LFVGISESCA | EAQVQLSLSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IFFQHQLGSV | LTVYIMCTSI | GTFLGPLIAG | YISAFTNFRW | VGWVAVIISG | GLLITIIFGC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EETYFDRGQY | MTPLTSCQSG | YEDGTTLQNS | DNTAVSRRKR | HLDAKLSTPG | AMGEKGVDLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ETAEFEVNNE | EEVTIPETRE | LIDGSKEHLK | PYPKRVAILT | KATNLKGYGF | KQYFKYLKIN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LRMFLFPPVW | LSGMFWGIQD | VFLTFYLTTQ | ESAYYEPPWN | YSDFGVAIMN | VPTLIGAVIG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CICAGIVSDY | FVLWMARHNR | GILEAEFRLY | FSIATAIIGP | AGLLMFGIGT | ARQWPWQAIY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VGLGFVGFAW | GCSGDIAMAY | LMDCYPDMVL | EGMVCTAIIN | NTISCIFTFT | CSDWLAASGT |
| 550 | 560 | 570 | 580 | ||
| ENTYIALAVI | NFGITAFALP | MYYYGKRIRL | WTKRWYLQSV | NLRDGV |