P53360

SS
Gene name
TBP (TFIID)
Protein name
TATA-box-binding protein
Names
TATA sequence-binding protein, TATA-binding factor, TATA-box factor, Transcription initiation factor TFIID TBP subunit
Species
Mesocricetus auratus (Golden hamster)
KEGG Pathway
EC number
Protein Class

Descriptions

The TATA binding protein (TBP) is required for the expression of nearly all genes and is highly regulated both positively and negatively. Autoinhibition of TBP through dimerization contributes to transcriptional repression, even at repressive subtelomeric regions.

Autoinhibitory domains (AIDs)

10-67 (TAF1 TAND domain) SS

Target domain

159-338 (TATA binding domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53360

Entry ID Method Resolution Chain Position Source
AF-P53360-F1 Predicted AlphaFoldDB

No variants for P53360

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P53360

No associated diseases with P53360

1 regional properties for P53360

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 262 - 311 IPR030491

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
RNA polymerase II general transcription initiation factor binding Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
RNA polymerase III general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III.

3 GO annotations of biological process

Name Definition
DNA-templated transcription, initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription by RNA polymerase III The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQREQQ
70 80 90 100 110 120
QQQQQQQQQQ QQAVATAAAS VQQSTSQQST QGASGQTPQL FHSQTLTTAP LPGTTPLYPS
130 140 150 160 170 180
PMTPMTPITP ATPASESSGI VPQLQNIVST VNLGCKLDLK TIALRARNAE YNPKRFAAVI
190 200 210 220 230 240
MRIREPRTTA LIFSSGKMVC TGAKSEEQSR LAARKYARVV QKLGFPAKFL DFKIQNMVGS
250 260 270 280 290 300
CDVKFPIRLE GLVLTHQQFS SYEPELFPGL IYRMIKPRIV LLIFVSGKVV LTGAKVRAEI
310
YEAFENIYPI LKGFRKTT