P53356

PR
Gene name
HTK16
Protein name
Tyrosine-protein kinase HTK16
Names
Species
Hydra vulgaris (Hydra) (Hydra attenuata)
KEGG Pathway
hmg:100200602
EC number
2.7.10.2: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

338-504 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

625-650 (Activation loop from InterPro)

Target domain

484-740 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P53356

Entry ID Method Resolution Chain Position Source
AF-P53356-F1 Predicted AlphaFoldDB

No variants for P53356

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P53356

No associated diseases with P53356

10 regional properties for P53356

Type Name Position InterPro Accession
domain Protein kinase domain 484 - 740 IPR000719
domain SH2 domain 8 - 102 IPR000980-1
domain SH2 domain 285 - 379 IPR000980-2
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 484 - 739 IPR001245
repeat Ankyrin repeat 115 - 214 IPR002110-1
repeat Ankyrin repeat 219 - 281 IPR002110-2
active_site Tyrosine-protein kinase, active site 604 - 616 IPR008266
binding_site Protein kinase, ATP binding site 490 - 516 IPR017441
domain Tyrosine-protein kinase, catalytic domain 484 - 740 IPR020635
domain Shark-like, N-terminal SH2 domain 8 - 87 IPR035061

Functions

Description
EC Number 2.7.10.2 Protein-tyrosine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKNSDALLW YHGKITREVA VQVLLRKGGR DGFFLIRDCG NAPEDYVLSM MFRSQILHFQ
70 80 90 100 110 120
INCLGDNKFS IDNGPIFQGL DMLISYYKVI SDGLPCKLVD FCVGKIAPLY ALKYGLDTRL
130 140 150 160 170 180
HLACEEKNPN TVKELLQDSV IKENVNARSI SGLTALHISC SNGDNDIVAM LLNAGADASA
190 200 210 220 230 240
IDANGRTPVQ VVCFYNHAST LHLLISKGSA DFLKRSPNNG WVPLHEAAMR GSLECVKVLL
250 260 270 280 290 300
SFNASMYPRS LDGDTPRDLA LQYENYNVVE FFDNYPVNQP KTSITQWLHQ NLDRNGALII
310 320 330 340 350 360
LQNASMADGS FLIRSSIKCH GYYVLTLVYE KKTYHFQIKS RADRWFYIDD GPLFETLPHL
370 380 390 400 410 420
VDHYMQYADG LPTLLQFPVP SAENRKRPLP PTPTKNQLKL PVPPSRPIKN NNGLPQPLPY
430 440 450 460 470 480
PEFTNESDSD IFTRLECEKE KPLPKLPRPV VNHTEVPNSV NVGQKGDQTM KNNAQQNIIL
490 500 510 520 530 540
KESISFGKEL GVGEFGSVIK GIWLSPGGKE INVAMKTLHK DKMVQGEKEF LREALVMSQL
550 560 570 580 590 600
NHPCIVSLLG VCLGPPMILV QELVEMGALL DYLMDYQPEI QEVDLKLWAS QIAFGMMYLE
610 620 630 640 650 660
LKRFVHRDLA ARNILLANKK QVKISDFGLS RAVGTGSDYY QAKQGGRWPV RWYAPESINY
670 680 690 700 710 720
GTFSTKSDVW SYGITLWEMF TFGDLPYGEM TGNEVVSFLE HCGRLEKPDE CPIHTYSIML
730 740 750
SCWHIDPNKR PTFNELHSTF STDPEYEDVR IYRDRIK