P53344
Gene name |
COS6 (YGR295C) |
Protein name |
Protein COS6 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR295C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53344
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53344-F1 | Predicted | AlphaFoldDB |
92 variants for P53344
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-1082727 | 3 | E>D | No | SGRP | |
| s07-1082720 | 6 | L>I | No | SGRP | |
| s07-1082717 | 7 | K>E | No | SGRP | |
| s07-1082716 | 7 | K>R | No | SGRP | |
| s07-1082714 | 8 | N>D | No | SGRP | |
| s07-1082709 | 9 | E>D | No | SGRP | |
| s07-1082710 | 9 | E>G | No | SGRP | |
| s07-1082690 | 16 | S>P | No | SGRP | |
| s07-1082687 | 17 | V>F | No | SGRP | |
| s07-1082679 | 19 | Q>H | No | SGRP | |
| s07-1082680 | 19 | Q>R | No | SGRP | |
| s07-1082645 | 31 | L>V | No | SGRP | |
| s07-1082635 | 34 | S>N | No | SGRP | |
| s07-1082633 | 35 | S>G | No | SGRP | |
| s07-1082632 | 35 | S>N | No | SGRP | |
| s07-1082631 | 35 | S>R | No | SGRP | |
| s07-1082628 | 36 | F>L | No | SGRP | |
| s07-1082607 | 43 | I>M | No | SGRP | |
| s07-1082608 | 43 | I>N | No | SGRP | |
| s07-1082605 | 44 | Y>S | No | SGRP | |
| s07-1082593 | 48 | V>A | No | SGRP | |
| s07-1082591 | 49 | F>L | No | SGRP | |
| s07-1082580 | 52 | W>C | No | SGRP | |
| s07-1082530 | 69 | W>* | No | SGRP | |
| s07-1082529 | 69 | W>C | No | SGRP | |
| s07-1082527 | 70 | I>T | No | SGRP | |
| s07-1082528 | 70 | I>V | No | SGRP | |
| s07-1082514 | 74 | M>I | No | SGRP | |
| s07-1082501 | 79 | V>F | No | SGRP | |
| s07-1082495 | 81 | F>V | No | SGRP | |
| s07-1082491 | 82 | W>L | No | SGRP | |
| s07-1082492 | 82 | W>R | No | SGRP | |
| s07-1082483 | 85 | V>I | No | SGRP | |
| s07-1082477 | 87 | V>L | No | SGRP | |
| s07-1082464 | 91 | F>C | No | SGRP | |
| s07-1082465 | 91 | F>L | No | SGRP | |
| s07-1082462 | 92 | R>G | No | SGRP | |
| s07-1082461 | 92 | R>K | No | SGRP | |
| s07-1082458 | 93 | L>P | No | SGRP | |
| s07-1082425 | 104 | T>I | No | SGRP | |
| s07-1082402 | 112 | K>E | No | SGRP | |
| s07-1082398 | 113 | N>S | No | SGRP | |
| s07-1082386 | 117 | S>L | No | SGRP | |
| s07-1082384 | 118 | D>N | No | SGRP | |
| s07-1082381 | 119 | P>T | No | SGRP | |
| s07-1082377 | 120 | H>R | No | SGRP | |
| s07-1082375 | 121 | D>N | No | SGRP | |
| s07-1082366 | 124 | V>I | No | SGRP | |
| s07-1082337 | 133 | F>L | No | SGRP | |
| s07-1082323 | 138 | A>V | No | SGRP | |
| s07-1082311 | 142 | K>R | No | SGRP | |
| s07-1082296 | 147 | S>N | No | SGRP | |
| s07-1082288 | 150 | S>G | No | SGRP | |
| s07-1082287 | 150 | S>I | No | SGRP | |
| s07-1082269 | 156 | R>K | No | SGRP | |
| s07-1082263 | 158 | T>S | No | SGRP | |
| s07-1082261 | 159 | L>V | No | SGRP | |
| s07-1082228 | 170 | A>S | No | SGRP | |
| s07-1082204 | 178 | D>N | No | SGRP | |
| s07-1082173 | 188 | E>G | No | SGRP | |
| s07-1082149 | 196 | K>R | No | SGRP | |
| s07-1082139 | 199 | K>N | No | SGRP | |
| s07-1082129 | 203 | S>T | No | SGRP | |
| s07-1082090 | 216 | K>E | No | SGRP | |
| s07-1082075 | 221 | A>T | No | SGRP | |
| s07-1082051 | 229 | V>I | No | SGRP | |
| s07-1082040 | 232 | R>S | No | SGRP | |
| s07-1082029 | 236 | R>L | No | SGRP | |
| s07-1082023 | 238 | C>Y | No | SGRP | |
| s07-1081997 | 247 | H>N | No | SGRP | |
| s07-1081997 | 247 | H>Y | No | SGRP | |
| s07-1081969 | 256 | G>D | No | SGRP | |
| s07-1081967 | 257 | T>P | No | SGRP | |
| s07-1081967 | 257 | T>S | No | SGRP | |
| s07-1081961 | 259 | A>S | No | SGRP | |
| s07-1081954 | 261 | P>L | No | SGRP | |
| s07-1081955 | 261 | P>S | No | SGRP | |
| s07-1081942 | 265 | V>A | No | SGRP | |
| s07-1081918 | 273 | R>K | No | SGRP | |
| s07-1081914 | 274 | D>E | No | SGRP | |
| s07-1081916 | 274 | D>N | No | SGRP | |
| s07-1081758 | 326 | K>N | No | SGRP | |
| s07-1081694 | 348 | V>L | No | SGRP | |
| s07-1081670 | 356 | R>W | No | SGRP | |
| s07-1081667 | 357 | A>P | No | SGRP | |
| s07-1081667 | 357 | A>T | No | SGRP | |
| s07-1081666 | 357 | A>V | No | SGRP | |
| s07-1081661 | 359 | S>P | No | SGRP | |
| s07-1081603 | 378 | E>V | No | SGRP | |
| s07-1081600 | 379 | S>F | No | SGRP | |
| s07-1081601 | 379 | S>P | No | SGRP | |
| s07-1081594 | 381 | A>V | No | SGRP |
No associated diseases with P53344
No regional properties for P53344
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53344 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKENELKNEK | SVDVLSVKQL | ESQKTVLPQD | LFRSSFTWFC | YEIYKSLVFR | IWMLLWLPLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VWWKLSNNWI | YPLMVSLLVL | FWGPVFVLVI | FRLSRKRSLS | KQLTQFCKEI | TKNTPSSDPH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DWEVVAANLN | SYFYENKAWN | TKYFFFSAMS | CQEAFRTTLL | EPFSLKKDEA | AKVKSFKDSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PYIEEALEVY | FTEVEKQWKL | FNSEKSWSPV | GLEDAKLPKE | AYRFKLTWVL | KRIFNRRCLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFLFYLHNVF | ISRNDGTIAR | PLFLVVLFFI | MTRDFRNMRM | IVLSVKMEHK | MQFLSTIINE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QESGANGWDE | IAKKMNRYLF | EKKVWKNEEF | FFDGIDCEWF | FSHFFYRVLS | AKKSMRALSL |
| 370 | 380 | ||||
| NVELWPYIKE | AQLSCSEESL | A |