P53333

PR
Gene name
CWC22 (YGR278W)
Protein name
Pre-mRNA-splicing factor CWC22
Names
Complexed with CEF1 protein 22
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR278W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

456-577 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P53333

Entry ID Method Resolution Chain Position Source
5GM6 EM 350 A Z 1-577 PDB
5GMK EM 340 A Z 1-577 PDB
5LQW EM 580 A H 1-577 PDB
5MPS EM 385 A H 1-577 PDB
5MQ0 EM 417 A H 1-577 PDB
5WSG EM 400 A Z 1-577 PDB
5YLZ EM 360 A S 1-577 PDB
6BK8 EM 330 A L 1-577 PDB
6EXN EM 370 A H 1-577 PDB
6J6G EM 320 A Z 1-577 PDB
6J6H EM 360 A Z 1-577 PDB
6J6N EM 386 A Z 1-577 PDB
6J6Q EM 370 A Z 1-577 PDB
AF-P53333-F1 Predicted AlphaFoldDB

15 variants for P53333

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-1046806 24 H>Y No SGRP
s07-1046912 59 N>S No SGRP
s07-1046945 70 G>D No SGRP
s07-1046947 71 R>W No SGRP
s07-1047541 269 D>N No SGRP
s07-1047620 295 I>T No SGRP
s07-1047793 353 F>L No SGRP
s07-1047832 366 E>K No SGRP
s07-1048060 442 S>P No SGRP
s07-1048159 475 E>K No SGRP
s07-1048175 480 R>Q No SGRP
s07-1048369 545 E>K No SGRP
s07-1048408 558 G>R No SGRP
s07-1048411 559 S>P No SGRP
s07-1048415 560 R>K No SGRP

No associated diseases with P53333

2 regional properties for P53333

Type Name Position InterPro Accession
domain MIF4G-like, type 3 22 - 204 IPR003890
domain Initiation factor eIF-4 gamma, MA3 290 - 407 IPR003891

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTATIQDED IKFQRENWEM IRSHVSPIIS NLTMDNLQES HRDLFQVNIL IGRNIICKNV
70 80 90 100 110 120
VDFTLNKQNG RLIPALSALI ALLNSDIPDI GETLAKELML MFVQQFNRKD YVSCGNILQC
130 140 150 160 170 180
LSILFLYDVI HEIVILQILL LLLEKNSLRL VIAVMKICGW KLALVSKKTH DMIWEKLRYI
190 200 210 220 230 240
LQTQELSSTL RESLETLFEI RQKDYKSGSQ GLFILDPTSY TVHTHSYIVS DEDEANKELG
250 260 270 280 290 300
NFEKCENFNE LTMAFDTLRQ KLLINNTSDT NEGSNSQLQI YDMTSTNDVE FKKKIYLVLK
310 320 330 340 350 360
SSLSGDEAAH KLLKLKIANN LKKSVVDIII KSSLQESTFS KFYSILSERM ITFHRSWQTA
370 380 390 400 410 420
YNETFEQNYT QDIEDYETDQ LRILGKFWGH LISYEFLPMD CLKIIKLTEE ESCPQGRIFI
430 440 450 460 470 480
KFLFQELVNE LGLDELQLRL NSSKLDGMFP LEGDAEHIRY SINFFTAIGL GLLTEDMRSR
490 500 510 520 530 540
LTIIQEVEDA EEEEKKLREE EELEKLRKKA RESQPTQGPK IHESRLFLQK DTRENSRSRS
550 560 570
PFTVETRKRA RSRTPPRGSR NHRNRSRTPP ARRQRHR