P53320
Gene name |
MTM1 (YGR257C, G9175) |
Protein name |
Mitochondrial carrier protein MTM1 |
Names |
Manganese trafficking factor for mitochondrial SOD2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR257C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53320
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53320-F1 | Predicted | AlphaFoldDB |
3 variants for P53320
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-1007131 | 61 | V>I | No | SGRP | |
| s07-1006831 | 161 | P>A | No | SGRP | |
| s07-1006633 | 227 | E>K | No | SGRP |
No associated diseases with P53320
3 regional properties for P53320
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Mitochondrial substrate/solute carrier | 13 - 149 | IPR018108-1 |
| repeat | Mitochondrial substrate/solute carrier | 156 - 251 | IPR018108-2 |
| repeat | Mitochondrial substrate/solute carrier | 265 - 362 | IPR018108-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| mitochondrial transmembrane transport | The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. |
| pyridoxal phosphate transport | The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDRNTSNSL | TLKERMLSAG | AGSVLTSLIL | TPMDVVRIRL | QQQQMIPDCS | CDGAAEVPNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VSSGSKMKTF | TNVGGQNLNN | AKIFWESACF | QELHCKNSSL | KFNGTLEAFT | KIASVEGITS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWRGISLTLL | MAIPANMVYF | SGYEYIRDVS | PIASTYPTLN | PLFCGAIARV | FAATSIAPLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVKTKLQSIP | RSSKSTKTWM | MVKDLLNETR | QEMKMVGPSR | ALFKGLEITL | WRDVPFSAIY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WSSYELCKER | LWLDSTRFAS | KDANWVHFIN | SFASGCISGM | IAAICTHPFD | VGKTRWQISM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MNNSDPKGGN | RSRNMFKFLE | TIWRTEGLAA | LYTGLAARVI | KIRPSCAIMI | SSYEISKKVF |
| GNKLHQ |