P53306
Gene name |
GPI1 (YGR216C) |
Protein name |
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1 |
Names |
GPI-GlcNAc transferase complex subunit GPI1, GPI-GnT subunit GPI1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR216C |
EC number |
2.4.1.198: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53306
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53306-F1 | Predicted | AlphaFoldDB |
12 variants for P53306
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-924170 | 100 | P>S | No | SGRP | |
| s07-924145 | 108 | S>N | No | SGRP | |
| s07-924136 | 111 | G>D | No | SGRP | |
| s07-923986 | 161 | E>G | No | SGRP | |
| s07-923974 | 165 | G>D | No | SGRP | |
| s07-923975 | 165 | G>S | No | SGRP | |
| s07-923959 | 170 | S>T | No | SGRP | |
| s07-923944 | 175 | C>Y | No | SGRP | |
| s07-923926 | 181 | Y>C | No | SGRP | |
| s07-923719 | 250 | G>D | No | SGRP | |
| s07-923695 | 258 | S>C | No | SGRP | |
| s07-923686 | 261 | Q>R | No | SGRP |
No associated diseases with P53306
No regional properties for P53306
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53306 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.198 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| fungal-type cell wall organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. |
| GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPNYIFWPYE | SLFENSAAQG | PQVALAISFE | KTHFVVLGVC | EPQYLEEVSI | RPPYSVVATK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NNGAEGWNYK | VADPCNVHFR | IPKLKFMQFY | SSDPISLIIP | EKEVGLHSSV | GETLNYSKLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QHPRYKRDNK | KLSETLNIIN | LFPAYCKALN | ELYPFIQTSQ | ENLRGTMLNS | VAAWCSSTCI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKMVAKIGFY | LTFVICSIAS | LVSSLLNYSH | FQLVNYSAFV | QQIDLRCQQI | CYFPVQYERI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKKDNIQNVG | SMVEKDNSNS | QFSHSYMPSK | FYPDYILLYN | TIWLIINDIS | FGLILGAILI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENRDFLVSAS | HRVLKFFLYD | SLKTITETLA | NNPLGIKLNA | ELANFLSELF | LWVIEFSYTT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FIKRLIDPKT | LSSLLTLTIY | MMFLVGFSFA | VSLAIDFFAI | LSFPIYVFYR | ISSKLYHCQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NIMASLFNLF | CGKKRNVLRN | RIDHNYFQLD | QLLLGTLLFI | ILVFLTPTVM | AFYMSYTVLR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MLTITIEIFS | EAVIALINHF | PLFALLLRLK | DPKRLPGGIS | IELKTTVSNK | HTTLELQNNP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IKFKSMFRPY | NLLLSQMRTN | YFSFATVRKI | VRGESIMVNR | NKLYYVLYSS | LPSKPLSVKD |
| LYKRLTIQA |