P53296
Gene name |
ATF2 |
Protein name |
Alcohol O-acetyltransferase 2 |
Names |
AATase 2, Acetyl-CoA:pregnenolone acetyltransferase, APAT |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR177C |
EC number |
2.3.1.84: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53296
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53296-F1 | Predicted | AlphaFoldDB |
18 variants for P53296
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-850372 | 24 | M>L | No | SGRP | |
| s07-850328 | 38 | K>N | No | SGRP | |
| s07-850252 | 64 | V>L | No | SGRP | |
| s07-850171 | 91 | E>K | No | SGRP | |
| s07-850048 | 132 | E>K | No | SGRP | |
| s07-849976 | 156 | L>V | No | SGRP | |
| s07-849802 | 214 | K>Q | No | SGRP | |
| s07-849576 | 289 | S>T | No | SGRP | |
| s07-849538 | 302 | S>G | No | SGRP | |
| s07-849529 | 305 | Q>E | No | SGRP | |
| s07-849344 | 366 | D>E | No | SGRP | |
| s07-849255 | 396 | G>V | No | SGRP | |
| s07-849192 | 417 | D>G | No | SGRP | |
| s07-849139 | 435 | E>Q | No | SGRP | |
| s07-849111 | 444 | A>V | No | SGRP | |
| s07-848977 | 489 | F>L | No | SGRP | |
| s07-848943 | 500 | G>D | No | SGRP | |
| s07-848854 | 530 | G>S | No | SGRP |
No associated diseases with P53296
No regional properties for P53296
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53296 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.84 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alcohol O-acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester. |
| N-acetyltransferase activity | Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| acetate ester metabolic process involved in fermentation | Any acetate ester metabolic process that is involved in fermentation. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
| sterol acetylation | The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDIEGYEPH | ITQELIDRGH | ARRMGHLENY | FAVLSRQKMY | SNFTVYAELN | KGVNKRQLML |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLKVLLQKYS | TLAHTIIPKH | YPHHEAYYSS | EEYLSKPFPQ | HDFIKVISHL | EFDDLIMNNQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEYREVMEKI | SEQFKKDDFK | VTNRLIELIS | PVIIPLGNPK | RPNWRLICLP | GKDTDGFETW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNFVYVTNHC | GSDGVSGSNF | FKDLALLFCK | IEEKGFDYDE | EFIEDQVIID | YDRDYTEISK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPKPITDRID | YKPALTSLPK | FFLTTFIYEH | CNFKTSSEST | LTARYSPSSN | ANASYNYLLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSTKQVEQIR | AQIKKNVHDG | CTLTPFIQAC | FLVALYRLDK | LFTKSLLEYG | FDVAIPSNAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFLPNDEELR | DSYKYGSNVG | GSHYAYLISS | FDIPEGDNDK | FWSLVEYYYD | RFLESYDNGD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HLIGLGVLQL | DFIVENKNID | SLLANSYLHQ | QRGGAIISNT | GLVSQDTTKP | YYVRDLIFSQ |
| 490 | 500 | 510 | 520 | 530 | |
| SAGALRFAFG | LNVCSTNVNG | MNMDMSVVQG | TLRDRGEWES | FCKLFYQTIG | EFASL |