P53294

PR
Gene name
PUS6 (YGR169C)
Protein name
tRNA pseudouridine(31) synthase
Names
Pseudouridine synthase 6, Pseudouridylate synthase 6, Uracil hydrolyase, tRNA pseudouridine 31 synthase, PSI31 synthase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR169C
EC number
5.4.99.42: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53294

Entry ID Method Resolution Chain Position Source
AF-P53294-F1 Predicted AlphaFoldDB

13 variants for P53294

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-835899 4 I>L No SGRP
s07-835536 125 D>N No SGRP
s07-835455 152 E>K No SGRP
s07-835441 156 L>F No SGRP
s07-835373 179 K>R No SGRP
s07-835253 219 N>S No SGRP
s07-835242 223 T>A No SGRP
s07-835152 253 T>A No SGRP
s07-835128 261 F>L No SGRP
s07-834933 326 N>D No SGRP
s07-834857 351 R>Q No SGRP
s07-834812 366 K>R No SGRP
s07-834701 403 N>S No SGRP

No associated diseases with P53294

2 regional properties for P53294

Type Name Position InterPro Accession
domain Pseudouridine synthase, RsuA/RluA-like 128 - 292 IPR006145
conserved_site Pseudouridine synthase, RluA-like, conserved site 164 - 178 IPR006224

Functions

Description
EC Number 5.4.99.42 Transferring other groups
Subcellular Localization
  • Cytoplasm
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

2 GO annotations of biological process

Name Definition
enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O16686 K07E8.7 Uncharacterized protein K07E8.7 Caenorhabditis elegans PR
10 20 30 40 50 60
MSTIKVIEVY TQNGLRKVRP YYNRRSAFVK GRWLGKLLID VLVSEFKLRP RAYYLDQIRK
70 80 90 100 110 120
GTYRLIRDGV PLVPDHLMTT IIKNHDVLET TTHKHEPPVK QWCSQEVEAE DLPGRIAGFN
130 140 150 160 170 180
IVFEDESILV IDKPSGIPVH PTGQFYQNTI TELLKLHGVD ALPCYRLDKI TSGLLILAKN
190 200 210 220 230 240
SQSAGEIQKS IRSRDMIKIY LARVKGRFPH SELILDNENA AETTFEDTSK VTVEMTPIYS
250 260 270 280 290 300
IDPKRQFPVG LSTSKDAITK FYPIRYFSHA DETVVACKPI TGRTHQIRIH LARLGHPIVN
310 320 330 340 350 360
DSVYCSHITK YPERLKFITQ FPRWENQQDL DAEELKVRFQ KFVDETKNNC RTMETFCPEC
370 380 390 400
HTVDLKDPVL SDLELWLHAW KYEEINGKFK FKTDLPKWAQ LDNS