P53253

PR
Gene name
NNF2 (YGR089W)
Protein name
Protein NNF2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR089W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53253

Entry ID Method Resolution Chain Position Source
AF-P53253-F1 Predicted AlphaFoldDB

21 variants for P53253

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-657225 88 G>S No SGRP
s07-657294 111 S>P No SGRP
s07-657387 142 G>S No SGRP
s07-657393 144 D>N No SGRP
s07-657550 196 I>T No SGRP
s07-657570 203 S>P No SGRP
s07-657642 227 L>F No SGRP
s07-657798 279 G>S No SGRP
s07-657802 280 F>S No SGRP
s07-657873 304 V>I No SGRP
s07-657999 346 S>P No SGRP
s07-658026 355 A>T No SGRP
s07-658181 406 F>L No SGRP
s07-658232 423 D>E No SGRP
s07-658467 502 T>A No SGRP
s07-658527 522 S>P No SGRP
s07-658537 525 S>L No SGRP
s07-658617 552 T>A No SGRP
s07-658928 655 N>K No SGRP
s07-659193 744 F>I No SGRP
s07-659195 744 F>L No SGRP

No associated diseases with P53253

No regional properties for P53253

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P53253

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEEQFTNQKK VSHLQSLMNT KRSEQPTEFA KKHRFKDTLA LFLVFLSFNH FTSLCLLVSF
70 80 90 100 110 120
IVATKCKDFL ANCFIILFLS KKPSRHIGEV AHIDISTSKV TNGSSNRKSN SRFFGNSKNS
130 140 150 160 170 180
FVIPIPVLIC EILFAMLLKI YGGDYFVKPI KNLAISIIAS FLINDPSDCL SYATSCSVLY
190 200 210 220 230 240
AVSTNTFQRV SHFFDIIQLF DMSLRGTGQS IKLFTVFRKY SQFFKKLFSL FLPMPFKMLG
250 260 270 280 290 300
KHSDSMIYYL SFHILFFSFA SSLLHPHRQT AENKPLKKGF NSTKPDVARV QGLQKMRISS
310 320 330 340 350 360
SSSVSADSNT LEDQSPMIPN DPGGLSSSNQ TIHPSQQNNS PVPLSSHSNI LNPAASYPTD
370 380 390 400 410 420
ATSSFPYFTS MVKEYKSYQP SVISAEGSNS QAVTTTTSTT TSPTTFNFSG DNTSLSNEIS
430 440 450 460 470 480
LSDSSNGNSK KDSDFFSPSN DKYTNQLFEL NVDFGNMFSS SKLSSDISVT SNLENFIRLL
490 500 510 520 530 540
FRRKNQHLIA PLWSMVVTLK TTNFEKKYLQ ETSENSLTPT NSNTSYVSNQ EKHDKDLDTI
550 560 570 580 590 600
NTHSVSSRIS FTHAGKFKKS VFNNFEPSNT MALIAKTTSD DYNLLNLVST NENIFNRNDN
610 620 630 640 650 660
DYKVCIIDIS TNSITFHIEN LHDGELIVLV NGVIWSEVSC ALILEHVGEE YVVVNGLVPS
670 680 690 700 710 720
CSYDIQFINR LNHRDDYLVS DLIVRTCGNN NAIAGKFENL DFSFPSYYHR KFLSPLLTLK
730 740 750 760 770 780
HSVLTTNANL SDERTKLKKT KKEFSKKLSL LRQEIDYFKG RISQNATHDE KSTLKVENLK
790 800 810 820 830 840
VALQQSETAV NKLEMQLKTL TEKELELEEE YLKKKDLHLK NQLEFSKLEE SLSKDLKNSE
850 860 870 880 890 900
GRFQKVNQEL VQLGSKLDKL NARNEKLQKE VDQNAEEIEK FSTQFLSKRE KDRFRRKEYR
910 920 930
IREANKFELT IKGLEQDINR LENENENIHS LIGNSY