P53235
Gene name |
YGR054W |
Protein name |
Eukaryotic translation initiation factor 2A |
Names |
eIF-2A |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR054W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53235
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53235-F1 | Predicted | AlphaFoldDB |
8 variants for P53235
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-597043 | 116 | V>A | No | SGRP | |
| s07-597130 | 145 | G>A | strain: SK1 [UniProt] | No | SGRP |
| s07-597191 | 165 | N>K | strain: SK1 [UniProt] | No | SGRP |
| s07-597255 | 187 | Y>H | No | SGRP | |
| s07-597342 | 216 | L>F | No | SGRP | |
| s07-597738 | 348 | L>I | No | SGRP | |
| s07-598084 | 463 | S>F | No | SGRP | |
| s07-598401 | 569 | P>S | strain: SK1 [UniProt] | No | SGRP |
No associated diseases with P53235
1 regional properties for P53235
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Translation initiation factor, beta propellor-like domain | 228 - 427 | IPR013979 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosolic ribosome | A ribosome located in the cytosol. |
| cytosolic small ribosomal subunit | The small subunit of a ribosome located in the cytosol. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| ribosome binding | Binding to a ribosome. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| tRNA binding | Binding to a transfer RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSQFFLKTS | QDIELFQSYP | TFEQSNTNSK | DFPVISSVLS | PCGRFLALST | KENVKVFTGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CLDNVLLTMK | LSDVYDLHFS | PAGNYLSTWE | RASIQDPNHK | NVKVWYLNKP | FKKDCVSEDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPAYEYQAKS | QSGWFLQFSK | LDNYGLRLFK | HDLKIVKLSS | ANADNFDFQS | PFAVLSDDET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQHFTTYLIS | PAEHPTICTF | TPEKGGKPAQ | LIIWALSEGK | ITKKIASKTF | FKADSCQLKW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPLGNAILCL | AITDFDSSNK | SYYGENTLYL | LSFQGVNGTL | GGNSVRVSLT | TGPVHDFTWS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PTSRQFGVIA | GYMPATISFF | DLRGNVVHSL | PQQAKNTMLF | SPSGHYILIA | GFGNLQGSVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILDRLDKFKC | VSKFDATNTS | VCKWSPGGEF | IMTATTSPRL | RVDNGVKIWH | VSGSLVFVKE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FKELLKVDWR | SPCNYKTLEN | KDEAFFENHI | INNWEPLPDS | TTSSLDPKIS | NKSELQIHSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VQEYISQHPS | REASSNGNGS | KAKAGGAYKP | PHARRTGGGR | IVPGVPPGAA | KKTIPGLVPG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MSANKDANTK | NRRRRANKKS | SETSPDSTPA | PSAPASTNAP | TNNKETSPEE | KKIRSLLKKL |
| 610 | 620 | 630 | 640 | ||
| RAIETLKERQ | AVGDKLEDTQ | VLKIQTEEKV | LKDLEKLGWK | DE |