P53184

PR
Gene name
PNC1 (YGL037C)
Protein name
Nicotinamidase
Names
Nicotinamide deamidase, NAMase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGL037C
EC number
3.5.1.19: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P53184

Entry ID Method Resolution Chain Position Source
2H0R X-ray 290 A A/B/C/D/E/F/G 1-216 PDB
3V8E X-ray 271 A A/B/C/D/E/F/G 1-216 PDB
AF-P53184-F1 Predicted AlphaFoldDB

1 variants for P53184

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-427485 157 V>I No SGRP

No associated diseases with P53184

1 regional properties for P53184

Type Name Position InterPro Accession
domain Isochorismatase-like 3 - 193 IPR000868

Functions

Description
EC Number 3.5.1.19 In linear amides
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Peroxisome
  • Concentrates in peroxisomes (PubMed:12736687)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nicotinamidase activity Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3.

4 GO annotations of biological process

Name Definition
negative regulation of DNA amplification Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification.
nicotinate nucleotide salvage The generation of nicotinate nucleotide without de novo synthesis.
rDNA heterochromatin assembly The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3.
subtelomeric heterochromatin assembly The compaction of chromatin into heterochromatin at the subtelomeric region.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLIVVDMQ NDFISPLGSL TVPKGEELIN PISDLMQDAD RDWHRIVVTR DWHPSRHISF
70 80 90 100 110 120
AKNHKDKEPY STYTYHSPRP GDDSTQEGIL WPVHCVKNTW GSQLVDQIMD QVVTKHIKIV
130 140 150 160 170 180
DKGFLTDREY YSAFHDIWNF HKTDMNKYLE KHHTDEVYIV GVALEYCVKA TAISAAELGY
190 200 210
KTTVLLDYTR PISDDPEVIN KVKEELKAHN INVVDK