P53125
Gene name |
ITC1 (YGL133W, G2842) |
Protein name |
Imitation switch two complex protein 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL133W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53125
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53125-F1 | Predicted | AlphaFoldDB |
22 variants for P53125
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-258105 | 132 | S>P | No | SGRP | |
| s07-258115 | 135 | T>R | No | SGRP | |
| s07-258153 | 148 | D>N | No | SGRP | |
| s07-258777 | 356 | A>T | No | SGRP | |
| s07-258823 | 371 | P>L | No | SGRP | |
| s07-258963 | 418 | K>E | No | SGRP | |
| s07-259227 | 506 | P>S | No | SGRP | |
| s07-259341 | 544 | N>D | No | SGRP | |
| s07-259497 | 596 | E>K | No | SGRP | |
| s07-259599 | 630 | V>I | No | SGRP | |
| s07-259616 | 635 | D>E | No | SGRP | |
| s07-259627 | 639 | E>G | No | SGRP | |
| s07-259867 | 719 | A>D | No | SGRP | |
| s07-260083 | 791 | N>T | No | SGRP | |
| s07-260142 | 811 | P>S | No | SGRP | |
| s07-260203 | 831 | L>P | No | SGRP | |
| s07-260662 | 984 | R>L | No | SGRP | |
| s07-260742 | 1011 | D>N | No | SGRP | |
| s07-260757 | 1016 | I>V | No | SGRP | |
| s07-260854 | 1048 | E>G | No | SGRP | |
| s07-261198 | 1163 | I>V | No | SGRP | |
| s07-261409 | 1233 | S>F | No | SGRP |
No associated diseases with P53125
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CHRAC | An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| subtelomeric heterochromatin assembly | The compaction of chromatin into heterochromatin at the subtelomeric region. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLYKRKPIL | LPDPKPLPLD | LNVQVWHIEE | TGEWFSSYEE | FLERFDFYTR | HHFTCEITGT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SCLTFFQALD | SEETQFKYVE | DRFPLKLREP | VARFLHFNGI | RRLDALVEKV | YARFKNDFFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEVVYLRKQK | DSSTTSSNSQ | QSTPQPDDMV | EINSVGNPGL | PQYQYQRRYV | IKEKVQFNAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INPESREIVM | PAHTKYMLIE | EAASSNKSFI | VDQGQIYRDR | STFTKHLIKC | FFKITLQRAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKMGAPWCVK | PEYLAMYGLT | MEWPKDMLKY | KEDEPVVARR | SNSANVSSPE | SEKNKRQSKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SGKSNTSNDA | SNKKETKKKR | KPTEVNDSEN | NSSEEDKKKG | QNVTSETHSK | KRKKEANEEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NTENVESVPT | PANAEPQAVT | ITSIMDDLAL | PYQHPPNIFP | NLTYYNEKLE | CISLGSTKLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RPFDSFGKLL | QAYQFLNTFG | SKICLSHFSL | DQFITSLKCT | DPYELKGEVV | LVNIRTQTSK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EQEIENNGLP | MKNKAETTTE | EDSENPSDWQ | RNSFIRDMIM | KRNSDKVEYK | IVHDDPASDD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILDNINHNGS | ALLIEVFTAL | LRLFINEEGD | WSCIVVENWI | IDDKGVLMER | KDERGEGEAK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QKRNAHGYFL | QDKEKIDNLK | DTLKENATEV | QKESDAKNET | NSESDSKSDS | DSEERDPKLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KCLNYRNVNW | IERLTKRQFN | NSYWLIILLG | VLEDCRHLPM | YTEFIDSFIE | KIIPKDISAT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QLPKQLWRNF | CRKLSFSDKV | NALWILVDLV | SHFSPDIKAA | VDDSMELCGQ | IRSERFKVAR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ELKTEAAVLS | NLQGDLQAIQ | EKLNKTDENT | PSADGADKKD | DSESNSEPID | LIIIEKKQKL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IEEQDKKVQA | LQSDKNFLDN | CLFENDLQRL | KPLGLDRYGN | RYFWLDHNGV | PFPQYPAGMN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ETPKSNNSLS | YHSGRLLIQG | PKASSAKFFL | NVSDEQLSNW | QKIRNSEGIS | EATREVFGIS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KTSSGSYNYV | ENGIEVELLD | SNDRVNPLIE | LTPIQKKIMD | ETPSRLLLSP | DQWYCIDKLE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DLSRIMDWLD | NWGRKEHDLL | RQIRPIMERI | KSSLSLRDHA | LSLTAFTKNE | EKLLKELENN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EFTENELNVD | SMDVDDKNSG | VKSEVDVQVD | AEEKREAVID | EKLEVIADEL | MKLDDSSKTR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NVLNRIQELE | DQRDELLEQK | KSIINSQRPG | ARILARSERK | RTKISRGNKV | NKQIEILTDL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VNYRHFKAME | DVIAWKNVLA | NSIWGSSLRK | NASGNKRSGV | IETVDDKLKD | IVGQTSRTVT |
| PAPN |