P53099
Gene name |
TPN1 (YGL186C, G1370) |
Protein name |
Vitamin B6 transporter TPN1 |
Names |
Transport of pyridoxine protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL186C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53099
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53099-F1 | Predicted | AlphaFoldDB |
5 variants for P53099
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-152563 | 74 | Q>E | No | SGRP | |
| s07-152416 | 123 | V>L | No | SGRP | |
| s07-152358 | 142 | I>T | No | SGRP | |
| s07-151612 | 391 | F>L | No | SGRP | |
| s07-151090 | 565 | V>L | No | SGRP |
No associated diseases with P53099
No regional properties for P53099
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53099 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| vitamin B6 transmembrane transporter activity | Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other. |
| vitamin transmembrane transporter activity | Enables the transfer of a vitamin from one side of a membrane to the other. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| vitamin transport | The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNRDNMDTTK | RKEDHTKHTT | DVIEFYEEGT | AASSLNIATE | KANSSPSILR | RIINRAAWLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKVDAMGVES | TGIQRISPYE | RGTSKKQFLH | VAGLWLSATG | GLSSMSSFLL | GPLLFGLSFR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESVASSLISV | TIGCLIAAYC | SIMGPQSGCR | QMVTARYLFG | WWFVKLVALA | SIIGVMGWSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNSVVGGEML | AAISNDKVPL | WVGIVIVTVC | SFLVAIFGIK | QVIKVETYLS | VPVLTAFLLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YISSSDKYSF | VNAYVSKGNL | DSSTRKGNWM | SFFSLCYSIT | ATWGSITADY | YILFPEDTPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IQIFCLTFFG | TFLPTCFVGI | LGLLLASVAM | SYKPWSVEYD | SHGMGGLLWA | GFQRWNGFGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FCVVVLVFSL | VSNNIINTYS | AAFSIQLSSV | FCAKIPRWFW | SIVCTIICLV | CALIGRNHFS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TILGNFLPMI | GYWISMYFIL | LFEENLVFRR | FFLHLYTKEF | PTVTGEINGP | ELVGSSKEVE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KDAVTNIHLL | KRKHKVTKHR | YNWDKWEDYE | VLTHGYAATF | AFIVGVAGVV | VGMAQAYWIG |
| 550 | 560 | 570 | |||
| PIAAKFGEYG | GDVAMWLSMA | FSGVVYPPCR | YLELRKFGR |