P53038
Gene name |
TEL2 (YGR099W) |
Protein name |
Telomere length regulation protein TEL2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR099W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P53038
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3O4Z | X-ray | 310 A | PDB | ||
| AF-P53038-F1 | Predicted | AlphaFoldDB |
18 variants for P53038
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-687943 | 14 | Q>R | No | SGRP | |
| s07-688192 | 97 | I>T | No | SGRP | |
| s07-688206 | 102 | P>S | No | SGRP | |
| s07-688210 | 103 | G>A | No | SGRP | |
| s07-688275 | 125 | L>I | No | SGRP | |
| 129 | S>R | TEL2-1; short telomere length [UniProt] | No | ||
| s07-688375 | 158 | S>N | No | SGRP | |
| s07-688498 | 199 | F>S | No | SGRP | |
| s07-688760 | 286 | K>N | No | SGRP | |
| s07-688780 | 293 | E>G | No | SGRP | |
| s07-688905 | 335 | S>G | No | SGRP | |
| s07-688906 | 335 | S>N | No | SGRP | |
| s07-689029 | 376 | D>G | No | SGRP | |
| s07-689174 | 424 | E>D | No | SGRP | |
| s07-689424 | 508 | T>A | No | SGRP | |
| s07-689458 | 519 | N>S | No | SGRP | |
| s07-689556 | 552 | L>V | No | SGRP | |
| s07-689952 | 684 | S>P | No | SGRP |
No associated diseases with P53038
4 regional properties for P53038
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, TFIIS-type | 305 - 346 | IPR001222 |
| domain | Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type | 7 - 81 | IPR003617 |
| domain | Transcription elongation factor S-II, central domain | 182 - 302 | IPR003618 |
| domain | Transcription factor IIS, N-terminal | 5 - 82 | IPR017923 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| ASTRA complex | A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| TTT complex | A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| Hsp90 protein binding | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA damage checkpoint | Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. |
| protein localization to chromosome | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLETLKQGL | DSSQIHEALI | QLDSYPREPV | DLDASMVLIK | FVIPVYPSLP | ERSKVILRRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ASKSFTFLCQ | IVTFSRTISG | RDGLQEIRIY | QEILEDIISF | EPGCLTFYLK | ASTTSKADRD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIKALFFGSK | LFNVLANRID | MAKYLGYLRL | QWKFLLESNE | TDPPGFLGEW | LVSSFLLNPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAADMLLGEL | FLLKESYFFS | FQKIISASSL | IDQKRLIAKF | LLPYIQVIVT | LENLNDVRKI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRRFDLDKII | SLSVLFEIQS | LPLKEVIVRL | MSNHSSTKFV | SALVSKFADF | TDEEVDTKTC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELLVLFAVHN | LNHSQREEIA | HDERFLNGVT | KHLGSNEREA | RERAMFIAKL | LSGGHLKYES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DFKINIPNVK | FESNSDDKII | DFQSLKNPSI | CNTQTDVGKD | KITEVSGHVQ | SLTLDCSDSD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DEDENDEREI | VKRIVFLKDL | MKEYEKTGES | RKAPLIPLLK | QTVKLIRQKA | DFQLEVGYYA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QGILSSIVCL | NNEFDEPLFE | QWRINALTSI | LVVLPEKVNG | AINILFNSEL | SLQQRMSLLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ALGLSARELR | GLDDPTIVKP | KFDFPTNRLP | WDDQSHHNSR | LVEVQESTSM | IKKTKTVWKS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RKLGKDREKG | TQNRFRKYAG | LFFYPLAHGW | LNGIDVGTYN | QLFKSHYLTT | LRIIYSCANP |
| 670 | 680 | ||||
| VHDFESMTEL | MNHIISSAIE | EGISLNKG |