Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53031
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53031-F1 | Predicted | AlphaFoldDB |
No variants for P53031
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P53031 | |||||
No associated diseases with P53031
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| negative regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| negative regulation of induction of conjugation with cellular fusion | Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion. |
| negative regulation of septation initiation signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling. |
| positive regulation of protein dephosphorylation | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLDFSQCFG | DKGDIENITE | ADIISTVEFD | HTGDFLATGD | KGGRVVLFER | NQSKKKQSCE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YKFFTEFQSH | DAEFDYLKSL | EIEEKINKIK | WLKSANDSLC | LLSTNDKTIK | LWKIQERQIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVSENNLNGL | NHLPSSNIGI | ESLKLPQLQL | HDKLISAQPK | KIYANAHAYH | INSISVNSDQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETYLSADDLR | INLWNLGIAD | QSFNIVDIKP | ANMEELTEVI | TSAEFHPLQC | NLFMYSSSKG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIKLSDMRSN | SLCDSHAKIF | EEYLDPSSHN | FFTEITSSIS | DVKFSHDGRY | IASRDYMTVK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IWDLAMENKP | IKTIDVHEHL | RERLCDTYEN | DAIFDKFEVQ | FGGDNKSVMT | GSYNNQFVIY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PNAVNTGNDD | KPKFKSAFKN | SSKRSKKNGF | STRTTDDDDD | DDDDDDDEEA | DDEFDEEVPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TKNSPGSQLE | DDDEQEEIIL | QADKSAFKSK | KSGQHPMRRR | MTSGVGSNLG | REFDDVDFKK |
| 490 | 500 | ||||
| SILHLSWHPR | ENSVAIAATN | NLYIFSTL |