P52991

PR
Gene name
thrB
Protein name
Homoserine kinase
Names
HK, HSK
Species
Lactococcus lactis subsp cremoris (Streptococcus cremoris)
KEGG Pathway
EC number
2.7.1.39: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

158-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52991

Entry ID Method Resolution Chain Position Source
AF-P52991-F1 Predicted AlphaFoldDB

No variants for P52991

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52991

No associated diseases with P52991

3 regional properties for P52991

Type Name Position InterPro Accession
conserved_site GHMP kinase, ATP-binding, conserved site 83 - 94 IPR006203
domain GHMP kinase N-terminal domain 76 - 137 IPR006204
domain GHMP kinase, C-terminal domain 201 - 261 IPR013750

Functions

Description
EC Number 2.7.1.39 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
homoserine kinase activity Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIIVPATSA NLGAGFDSIG IAVNLYLTVE VLGESRDWKI DHDLGENIPT DERNLLLTTL
70 80 90 100 110 120
SAVLEDKNVA LSAKFHLKMT SEVPLARGLG SSSSVIIAGI ELANQLAKLN LTSDEKLKLA
130 140 150 160 170 180
CEIEGHPDNV APALLGNLVI ASTVAGKTSH IVADFPSCAL LAFVPDYELK TVESRKVLPN
190 200 210 220 230 240
ELTYKEAVAA SSIANVLTAS LLTNNLEVAG QMMEADRFHE SYRASLIPEL QLLREIGHEF
250 260 270 280 290
GAYGTYLSGA GPTVMLLVPD DKLTLLTEKI MEKNLTGHLY PLKIDNKGLQ VEESVF