P52713

PR
Gene name
alh-8 (F13D12.4)
Protein name
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Names
MMSDH, Malonate-semialdehyde dehydrogenase [acylating]
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_F13D12.4
EC number
1.2.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-184 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52713

Entry ID Method Resolution Chain Position Source
AF-P52713-F1 Predicted AlphaFoldDB

No variants for P52713

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52713

No associated diseases with P52713

2 regional properties for P52713

Type Name Position InterPro Accession
domain Aldehyde dehydrogenase domain 40 - 502 IPR015590
conserved_site Aldehyde dehydrogenase, cysteine active site 300 - 311 IPR016160

Functions

Description
EC Number 1.2.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
fatty-acyl-CoA binding Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
malonate-semialdehyde dehydrogenase (acetylating) activity Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-).
methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.

4 GO annotations of biological process

Name Definition
thymine catabolic process The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
thymine metabolic process The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
valine catabolic process The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSRLARVQP KCQQLAHFST SKSAAAAPTV KLWIDGQAVE SKTTDFVELT NPATNEVIAM
70 80 90 100 110 120
VPNATQAEMQ AAVDSAKNAF NTWKNTSPLT RQQCMFKLQA LIKRDMKKLA ESITIEQGKT
130 140 150 160 170 180
LPDAEGDVSR GLQVVEHACS VPSLMMGETL PNVSRDMDTH SYRIPLGVTA GICPFNFPAM
190 200 210 220 230 240
IPLWMFPVAL ATGNTMVIKP SEQDPGAAQL LVELAKEAGV PDGCVNIIHG QHSAVNFICD
250 260 270 280 290 300
NPDIKAISFV GGDAAGKHIY ERGAKNGKRV QSNMGAKNHG VIMADANKEQ TLNQLTAAAF
310 320 330 340 350 360
GAAGQRCMAL TTAVLVGEAR AWLPELVEKA KNLKVNAGWK PDTDIGPLIS KQSKARVLRL
370 380 390 400 410 420
IESAKKEGAQ VPLDGSNITV PGFENGNFVG PTILAGVKPN MTCYREEIFG PVLVVMEAEN
430 440 450 460 470 480
LNEAIEIINN NPYGNGTAIF TSNGATARKF TNEVDVGQIG INVPIPVPLP MFSFTGSRGS
490 500 510 520
FLGDLNFYGK AGIQFYTQWK TVTQYWNESL TELKPQMSFP QLK