AiPD: Autoinhibited Protein Database

P52655

Gene name	GTF2A1 (TF2A1)
Protein name	Transcription initiation factor IIA subunit 1
Names	General transcription factor IIA subunit 1, TFIIAL, Transcription initiation factor TFIIA 42 kDa subunit, TFIIA-42
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2957
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

243-316 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

243-316 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

50 structures for P52655

Entry ID	Method	Resolution	Chain	Position	Source
1NVP	X-ray	210 A			PDB
5FUR	EM	850 A			PDB
5IY6	EM	720 A	N	1-376	PDB
5IY7	EM	860 A	N	1-376	PDB
5IY8	EM	790 A	N	1-376	PDB
5IY9	EM	630 A	N	1-376	PDB
5IYA	EM	540 A	N	1-376	PDB
5IYB	EM	390 A	N	1-376	PDB
5IYC	EM	390 A	N	1-376	PDB
5IYD	EM	390 A	N	1-376	PDB
5M4S	X-ray	238 A			PDB
6MZM	EM	750 A	W	9-376	PDB
6O9L	EM	720 A	N	1-376	PDB
7EDX	EM	450 A	Q	1-376	PDB
7EG7	EM	620 A	Q	1-376	PDB
7EG8	EM	740 A	Q	1-376	PDB
7EG9	EM	370 A	Q	1-376	PDB
7EGA	EM	410 A	Q	1-376	PDB
7EGB	EM	330 A	Q	1-376	PDB
7EGC	EM	390 A	Q	1-376	PDB
7EGD	EM	675 A	Q	1-376	PDB
7EGI	EM	982 A	Q	1-376	PDB
7EGJ	EM	864 A	Q	1-376	PDB
7LBM	EM	480 A	M	1-376	PDB
7NVR	EM	450 A	U	1-376	PDB
7NVS	EM	280 A	U	1-376	PDB
7NVT	EM	290 A	U	1-376	PDB
7NVU	EM	250 A	U	1-376	PDB
7NVY	EM	730 A	U	1-376	PDB
7NVZ	EM	720 A	U	1-376	PDB
7NW0	EM	660 A	U	1-376	PDB
7ZWC	EM	320 A	U	1-376	PDB
7ZWD	EM	300 A	U	1-376	PDB
7ZX7	EM	340 A	U	1-376	PDB
7ZX8	EM	300 A	U	1-376	PDB
7ZXE	EM	350 A	U	1-376	PDB
8BVW	EM	400 A	U	1-376	PDB
8BYQ	EM	410 A	U	1-376	PDB
8BZ1	EM	380 A	U	1-376	PDB
8GXQ	EM	504 A	DQ	1-376	PDB
8GXS	EM	416 A	DQ	1-376	PDB
8WAK	EM	547 A	Q	1-376	PDB
8WAL	EM	852 A	Q	1-376	PDB
8WAN	EM	607 A	Q	1-376	PDB
8WAO	EM	640 A	Q	1-376	PDB
8WAP	EM	585 A	Q	1-376	PDB
8WAQ	EM	629 A	Q	1-376	PDB
8WAR	EM	720 A	Q	1-376	PDB
8WAS	EM	613 A	Q	1-376	PDB
AF-P52655-F1	Predicted				AlphaFoldDB

201 variants for P52655

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA390733500 rs1595236795	3	N>T		No	ClinGen Ensembl
CA390733495 rs1350403861	4	S>A		No	ClinGen TOPMed gnomAD
TCGA novel	4	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390733488 rs1455032542	5	A>G		No	ClinGen gnomAD
CA7294952 rs751806247	5	A>T		No	ClinGen ExAC gnomAD
rs763824221 CA7294951	6	N>D		No	ClinGen ExAC gnomAD
CA390733486 rs763824221	6	N>H		No	ClinGen ExAC gnomAD
TCGA novel rs200315855 CA263958337	6	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes gnomAD NCI-TCGA
CA390733474 rs1595236757	8	N>H		No	ClinGen Ensembl
rs1595236753 CA390733471	8	N>T		No	ClinGen Ensembl
CA390733466 rs1595236747	9	T>P		No	ClinGen Ensembl
rs1161031071 CA390733460	10	V>M		No	ClinGen gnomAD
CA390733435 rs1309045242	12	K>E		No	ClinGen gnomAD
TCGA novel	12	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1407628114 CA390733432	12	K>R		No	ClinGen TOPMed
CA390733416 rs1293283722	14	Y>C		No	ClinGen TOPMed gnomAD
CA390733410 rs1449603493	15	R>T		No	ClinGen gnomAD
rs1420999911 CA390733405	16	S>P		No	ClinGen gnomAD
CA390733399 rs1184448825	17	V>L		No	ClinGen gnomAD
rs760524289 CA7294925	20	D>H		No	ClinGen ExAC TOPMed gnomAD
CA390733355 rs1326970667	23	N>S		No	ClinGen TOPMed
CA390733342 rs1229253759	25	V>L		No	ClinGen TOPMed
VAR_035667	30	L>V	a breast cancer sample; somatic mutation [UniProt]	No	UniProt
CA390733279 rs1490005106	34	V>L		No	ClinGen gnomAD
CA390733247 rs1383523091	38	V>E		No	ClinGen gnomAD
CA390733243 rs1309372821	39	L>V		No	ClinGen gnomAD
CA7294923 rs200289434	40	M>K		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	41	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317136431 CA390733215	43	K>T		No	ClinGen TOPMed
CA390733205 rs1595232932	44	T>S		No	ClinGen Ensembl
TCGA novel	47	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	48	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1393345568 CA390732050	48	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	48	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754745611 CA7294879	51	M>T		No	ClinGen ExAC gnomAD
COSM197050 CA390732001 rs1444155041	55	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA390731987 rs1195660576	57	D>V		No	ClinGen gnomAD
rs1489300777 CA390731967	60	H>Y		No	ClinGen TOPMed
CA7294877 rs779698902	61	S>L		No	ClinGen ExAC gnomAD
rs755584424 CA7294876	62	E>V		No	ClinGen ExAC gnomAD
rs1189279846 CA390731945	63	E>G		No	ClinGen TOPMed
CA390731902 rs1355098841	69	Q>H		No	ClinGen gnomAD
rs1220120090 CA390731906	69	Q>P		No	ClinGen gnomAD
CA390731894 rs1270222060	71	Q>E		No	ClinGen gnomAD
CA7294874 rs746616919	71	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1414265441 CA390731859	75	Q>H		No	ClinGen TOPMed
rs200868697 CA263944562	75	Q>K		No	ClinGen 1000Genomes
CA7294870 rs759857062	76	P>S		No	ClinGen ExAC TOPMed gnomAD
CA390731844 rs1301877483	78	Q>K		No	ClinGen gnomAD
CA390731841 rs1424555510	78	Q>R		No	ClinGen gnomAD
CA263944529 rs979794325	82	H>Q		No	ClinGen TOPMed gnomAD
CA263944509 rs201567417	83	H>Q		No	ClinGen Ensembl
CA263944520 rs201983978	83	H>Y		No	ClinGen 1000Genomes
rs1326386458 CA390731779	86	H>R		No	ClinGen TOPMed
rs1460675118 CA390731781	86	H>Y		No	ClinGen TOPMed gnomAD
CA390731767 rs1310388030	87	H>Q		No	ClinGen Ensembl
CA390731769 rs1372784951	87	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA263944494 rs76069174	88	Q>*		No	ClinGen Ensembl
CA7294864 rs760695064	89	Q>R		No	ClinGen ExAC gnomAD
CA7294862 rs772748894	91	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs748662198 CA7294861	93	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA7294860 rs779479018	95	T>A		No	ClinGen ExAC TOPMed gnomAD
CA390731698 rs1196969592	98	Q>*		No	ClinGen gnomAD
rs1336863695 CA390731685	99	Q>H		No	ClinGen TOPMed gnomAD
CA263944443 rs552611415	100	A>S		No	ClinGen 1000Genomes
COSM1209155 rs768916940 CA7294859	100	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs779604498 CA7294857	101	Q>P		No	ClinGen ExAC gnomAD
CA390731653 rs1414689257	104	Q>H		No	ClinGen TOPMed
CA390731651 rs1407547285	105	V>I		No	ClinGen TOPMed
rs1281716549 CA390731635	107	I>T		No	ClinGen gnomAD
VAR_054043 rs17111579 CA263944419	109	A>P		No	ClinGen UniProt TOPMed dbSNP
CA390731626 rs17111579	109	A>T		No	ClinGen TOPMed
CA7294855 rs749949255	110	S>T		No	ClinGen ExAC gnomAD
CA7294854 rs780648477	111	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs751481940 CA7294852	113	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7294799 rs199739518	120	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1292857056 CA390731357	123	S>C		No	ClinGen gnomAD
rs1480605566 CA390731334	126	I>M		No	ClinGen gnomAD
CA390731339 rs1355738554	126	I>V		No	ClinGen gnomAD
rs1168154350 CA390731325	128	H>N		No	ClinGen gnomAD
CA7294797 rs770615006	128	H>R		No	ClinGen ExAC gnomAD
TCGA novel	131	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7294796 rs138294263	133	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1178940900 CA390731281	134	M>V		No	ClinGen gnomAD
CA390731259 rs1178036906	135	S>G		No	ClinGen gnomAD
rs1445303604 CA390731256	135	S>T		No	ClinGen gnomAD
rs1280431791 CA390731205	143	L>F		No	ClinGen TOPMed
rs760009596 CA7294780	143	L>I		No	ClinGen ExAC gnomAD
rs1318578922 CA390731183	147	A>E		No	ClinGen gnomAD
CA390731155 rs1306469145	151	P>S		No	ClinGen gnomAD
rs1238864494 CA390731140	153	Q>K		No	ClinGen gnomAD
rs1373911003 CA390730953	162	L>V		No	ClinGen gnomAD
rs1595216572 CA390730924	164	Q>R		No	ClinGen Ensembl
CA390730915 rs1362666235	165	V>L		No	ClinGen TOPMed
rs1433691806 CA390730889	167	R>S		No	ClinGen TOPMed
CA390730886 rs1595216555	168	A>P		No	ClinGen Ensembl
rs778963555 CA7294763	168	A>V		No	ClinGen ExAC gnomAD
rs1274939746 CA390730879	169	A>T		No	ClinGen TOPMed
rs147948047 CA7294762	170	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA390730847 rs1566855578	171	G>D		No	ClinGen Ensembl
CA390730840 rs1217436419	172	A>S		No	ClinGen TOPMed
CA7294761 rs754359577	174	Y>C		No	ClinGen ExAC gnomAD
rs1490475041 CA390730811	175	I>F		No	ClinGen gnomAD
CA263937110 rs936687867	176	F>L		No	ClinGen Ensembl
rs1329578672 CA390730792	177	Q>H		No	ClinGen TOPMed
CA390730779 rs1210402735	179	Q>H		No	ClinGen TOPMed
CA7294759 rs756534940	183	V>F		No	ClinGen ExAC gnomAD
rs535983219 CA263937040	189	I>L		No	ClinGen 1000Genomes
CA390730698 rs1247373412	191	Q>H		No	ClinGen TOPMed
rs1479269711 CA390730686	193	Q>*		No	ClinGen TOPMed
CA390730681 rs1316468939	193	Q>H		No	ClinGen gnomAD
CA390730678 rs1277918352	194	P>S		No	ClinGen gnomAD
rs1406094085 CA390730663	196	G>V		No	ClinGen gnomAD
rs1347871827 CA390730661	197	V>I		No	ClinGen gnomAD
CA263937030 rs920017522	199	A>G		No	ClinGen TOPMed
rs1397261123 CA390730641	200	P>S		No	ClinGen gnomAD
CA390730631 rs1169895027	202	I>L		No	ClinGen gnomAD
rs775569470 CA7294752	202	I>M		No	ClinGen ExAC gnomAD
rs762492938 CA7294753	202	I>R		No	ClinGen ExAC gnomAD
rs769812325 CA7294751	203	Q>R		No	ClinGen ExAC
rs972848028 CA263937008	204	Q>R		No	ClinGen TOPMed
rs900503612 CA263933697	207	A>T		No	ClinGen TOPMed
CA263933671 rs151035780	208	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA7294733 rs151035780	208	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs759390225 CA7294732	209	L>V		No	ClinGen ExAC gnomAD
rs776551423 CA7294731	215	P>A		No	ClinGen ExAC gnomAD
rs770648110 CA7294730	217	T>A		No	ClinGen ExAC gnomAD
rs1296182876 CA390730491	223	P>A		No	ClinGen gnomAD
CA390730481 rs1444026902	224	Q>R		No	ClinGen TOPMed
CA7294727 rs569178593	225	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	225	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379826598 CA390730456	228	F>L		No	ClinGen TOPMed
CA390730434 rs1238148117	231	N>S		No	ClinGen gnomAD
TCGA novel	234	Q>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1320932199 CA390730397	236	I>M		No	ClinGen TOPMed
CA7294724 rs756709499	236	I>T		No	ClinGen ExAC TOPMed gnomAD
rs780077444 CA7294725	236	I>V		No	ClinGen ExAC gnomAD
rs1242741904 CA390730395	237	P>A		No	ClinGen Ensembl
CA390730392 rs1232874185	237	P>R		No	ClinGen TOPMed
CA390730390 rs1360714051	238	T>A		No	ClinGen gnomAD
rs781681151 CA7294723	238	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7294722 rs781681151	238	T>R		No	ClinGen ExAC gnomAD
rs757566499 CA7294721	239	T>A		No	ClinGen ExAC gnomAD
rs751929090 CA7294720	241	A>V		No	ClinGen ExAC gnomAD
CA7294719 rs142893489	242	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7294718 rs758097664	243	P>S		No	ClinGen ExAC TOPMed gnomAD
CA7294717 rs752292521	244	T>A		No	ClinGen ExAC gnomAD
rs550854086 CA7294716	246	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7294715 rs550854086	246	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA7294714 rs535458284	246	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1288832212 CA390730341	247	Q>P		No	ClinGen gnomAD
rs199532026 CA263933499	249	Q>R		No	ClinGen TOPMed gnomAD
CA390730286 rs1292538699	250	I>K		No	ClinGen gnomAD
CA7294713 rs148530628	250	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230242604 CA390730241	253	T>A		No	ClinGen gnomAD
rs1377175956 CA390730231	253	T>I		No	ClinGen gnomAD
CA390730147 rs1283804846	258	P>L		No	ClinGen gnomAD
TCGA novel	259	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7294711 rs772971756	259	Q>R		No	ClinGen ExAC gnomAD
rs768907982 CA7294710	260	A>V		No	ClinGen ExAC gnomAD
rs1398014754 CA390730101	261	Q>K		No	ClinGen gnomAD
CA390730084 rs1423656476	262	P>S		No	ClinGen TOPMed
rs1359357429 CA390729986	266	Q>R		No	ClinGen gnomAD
rs934514610 CA263933456	271	L>S		No	ClinGen TOPMed
CA7294707 rs769776748	276	T>I		No	ClinGen ExAC gnomAD
CA7294706 rs374094911	279	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs781578392 CA7294705	280	S>L		No	ClinGen ExAC gnomAD
CA263933423 rs928338825	282	E>D		No	ClinGen Ensembl
CA7294704 rs771415588	282	E>Q		No	ClinGen ExAC gnomAD
CA390729654 rs1169373346	286	D>E		No	ClinGen TOPMed
rs747425299 CA7294702	289	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1319995088 CA390729554	293	D>G		No	ClinGen gnomAD
CA7294697 rs754481422 CA7294696	294	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1215359958 CA390729540	294	D>G		No	ClinGen TOPMed gnomAD
rs752413471 CA7294699	294	D>H		No	ClinGen ExAC TOPMed gnomAD
CA390729546 rs752413471	294	D>N		No	ClinGen ExAC TOPMed gnomAD
rs752413471 CA7294698	294	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs200502995 CA7294695	295	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs887820232 CA263933350	299	K>Q		No	ClinGen TOPMed gnomAD
CA390729435 rs1566853922	302	D>E		No	ClinGen Ensembl
rs766276254 CA7294694	302	D>V		No	ClinGen ExAC
rs745748481 CA263933319	302	D>Y		No	ClinGen Ensembl
rs760576204 CA7294693	304	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1424570272 CA390727277	327	E>D		No	ClinGen gnomAD
rs1438666622 CA390727178	332	E>D		No	ClinGen gnomAD
CA263926766 rs958495523	333	N>S		No	ClinGen Ensembl
CA390726119 rs1299371432	346	K>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA390726106 rs1358712108	348	K>*		No	ClinGen gnomAD
TCGA novel	349	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	352	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7294645 rs755210057	353	L>F		No	ClinGen ExAC
rs867553569 CA263922581	356	G>V		No	ClinGen Ensembl
TCGA novel	358	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766672017 CA7294643	361	N>S		No	ClinGen ExAC gnomAD
CA390726001 rs1260058499	362	G>E		No	ClinGen TOPMed
rs1421883806 CA390725967	367	F>L		No	ClinGen gnomAD
rs1256481522 CA390725955	368	S>F		No	ClinGen gnomAD
CA7294641 rs200244214	371	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA390725934 rs1357025118	372	G>R		No	ClinGen TOPMed
CA390725920 rs1211380717	374	A>T		No	ClinGen TOPMed
TCGA novel	376	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P52655

No regional properties for P52655

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P52655

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIA complex	A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
transcription factor TFIID complex	A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
transcription preinitiation complex	A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

7 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
RNA polymerase II core promoter sequence-specific DNA binding	Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
RNA polymerase II general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
RNA polymerase II general transcription initiation factor binding	Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).

4 GO annotations of biological process

Name	Definition
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transcription initiation by RNA polymerase II	Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.
RNA polymerase II preinitiation complex assembly	The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MANSANTNTV	PKLYRSVIED	VINDVRDIFL	DDGVDEQVLM	ELKTLWENKL	MQSRAVDGFH
70	80	90	100	110	120
SEEQQLLLQV	QQQHQPQQQQ	HHHHHHHQQA	QPQQTVPQQA	QTQQVLIPAS	QQATAPQVIV
130	140	150	160	170	180
PDSKLIQHMN	ASNMSAAATA	ATLALPAGVT	PVQQILTNSG	QLLQVVRAAN	GAQYIFQPQQ
190	200	210	220	230	240
SVVLQQQVIP	QMQPGGVQAP	VIQQVLAPLP	GGISPQTGVI	IQPQQILFTG	NKTQVIPTTV
250	260	270	280	290	300
AAPTPAQAQI	TATGQQQPQA	QPAQTQAPLV	LQVDGTGDTS	SEEDEDEEED	YDDDEEEDKE
310	320	330	340	350	360
KDGAEDGQVE	EEPLNSEDDV	SDEEGQELFD	TENVVVCQYD	KIHRSKNKWK	FHLKDGIMNL
370
NGRDYIFSKA	IGDAEW