Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P52498

Entry ID Method Resolution Chain Position Source
AF-P52498-F1 Predicted AlphaFoldDB

No variants for P52498

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52498

No associated diseases with P52498

1 regional properties for P52498

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 1 - 158 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GTP binding Binding to GTP, guanosine triphosphate.

2 GO annotations of biological process

Name Definition
regulation of establishment of cell polarity Any process that modulates the frequency, rate or extent of establishment of cell polarity.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRDYKVVVLG AGGVGKSSIT VQFVQGVYVE SYDPTIEDSY RKQIEVDGRA CDLEILDTAG
70 80 90 100 110 120
VAQFTAMREL YIKSGKGFLL VYSVTDENSL KELLALREQV LRIKDSDNVP MVLVGNKCDL
130 140 150 160 170 180
EDDRVLSIED GVKVSQDWGL VPFYETSAMY KTNVDEAFID VVRQIMRKEA AISAEKKQQK
190 200 210 220 230 240
ELQKQQQQQQ QEQDAEGQQQ QQKSGKSKSS ATQKDATADG QTDVNARLKQ SINDHPKSSS
GSKFCTII