P52486
Gene name |
Ubc4 |
Protein name |
Ubiquitin-conjugating enzyme E2-22 kDa |
Names |
E2 ubiquitin-conjugating enzyme 4, Ubiquitin carrier protein, Ubiquitin-protein ligase |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8284 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52486
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52486-F1 | Predicted | AlphaFoldDB |
No variants for P52486
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P52486 | |||||
No associated diseases with P52486
8 regional properties for P52486
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 263 - 284 | IPR001611 |
| repeat | Leucine-rich repeat, typical subtype | 199 - 220 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 260 - 284 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 302 - 326 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 346 - 368 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 370 - 389 | IPR003591-5 |
| domain | Novel E3 ligase domain | 472 - 680 | IPR029487 |
| domain | LRR-containing bacterial E3 ligase, N-terminal | 107 - 170 | IPR032674 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| proteasome binding | Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of peptidoglycan recognition protein signaling pathway | Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. |
| proteasome-mediated ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21734 | UBC1 | Ubiquitin-conjugating enzyme E2 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P61085 | UBE2K | Ubiquitin-conjugating enzyme E2 K | Bos taurus (Bovine) | PR |
| P35128 | ben | Ubiquitin-conjugating enzyme E2 N | Drosophila melanogaster (Fruit fly) | PR |
| P52487 | Ubc84D | Ubiquitin-conjugating enzyme E2-18 kDa | Drosophila melanogaster (Fruit fly) | PR |
| P25867 | eff | Ubiquitin-conjugating enzyme E2-17 kDa | Drosophila melanogaster (Fruit fly) | PR |
| Q9VX25 | CG8188 | Ubiquitin-conjugating enzyme E2 S | Drosophila melanogaster (Fruit fly) | SS |
| P61086 | UBE2K | Ubiquitin-conjugating enzyme E2 K | Homo sapiens (Human) | PR |
| P61087 | Ube2k | Ubiquitin-conjugating enzyme E2 K | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANMAVSRIK | REFKEVMRSE | EIVQCSIKIE | LVNDSWTELR | GEIAGPPDTP | YEGGKFVLEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KVPETYPFNP | PKVRFITRIW | HPNISSVTGA | ICLDILKDNW | AAAMTLRTVL | LSLQALLAAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPDDPQDAVV | AYQFKDKYDL | FLLTAKHWTN | AYAGGPHTFP | DCDSKIQRLR | DMGIDEHEAR |
| 190 | |||||
| AVLSKENWNL | EKATEGLFS |