Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52171
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52171-F1 | Predicted | AlphaFoldDB |
No variants for P52171
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P52171 | |||||
No associated diseases with P52171
9 regional properties for P52171
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 105 - 188 | IPR000225-1 |
| repeat | Armadillo | 190 - 231 | IPR000225-2 |
| repeat | Armadillo | 234 - 273 | IPR000225-3 |
| repeat | Armadillo | 275 - 315 | IPR000225-4 |
| repeat | Armadillo | 317 - 357 | IPR000225-5 |
| repeat | Armadillo | 359 - 399 | IPR000225-6 |
| repeat | Armadillo | 402 - 442 | IPR000225-7 |
| domain | Importin-alpha, importin-beta-binding domain | 1 - 95 | IPR002652 |
| repeat | Atypical Arm repeat | 451 - 502 | IPR032413 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTTNEADER | MRKFKNKGKD | TAELRRRRVE | VSVELRKAKK | DEQILKRRNV | CFPEELILSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKNAMQSIQV | PQLSLEEIVQ | GMNSGDNENE | LRSTQAARKM | LSKERNPPLN | DIIEAGLIPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVEFLSYHNN | STLQFEAAWA | LTNIASGTSD | QTKSVVDGGA | IPAFISLISS | PHLHISEQAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WALGNIAGDG | PLYRDALISC | NVIPPLLTLV | NPQTPLGYLR | NITWTLSNLC | RNKNPYPPMS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVLQILPVLT | QLMLHEDKDI | LSDTCWAMSY | LTDGSNDRID | VVVKTGLVER | LIQLMYSPEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SILTPSLRTV | GNIVTGTDKQ | TQAAIDAGVL | SVLPQLLRHQ | KPSIQKEAAW | ALSNIAAGPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PQIQQMITCG | LLSPLVDLLK | KGDFKAQKEA | VWAVTNYTSG | GTVEQVVQLV | QCGVLEPLLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLTIKDSKTI | LVILDAISNI | FLAAEKLGEQ | EKLCLLVEEL | GGLEKIEALQ | THDNRMVYHA |
| 490 | 500 | 510 | 520 | ||
| ALALIEKYFS | GEEADEMNAL | EPEVGNDAYT | FQVPNMQKES | FKF |