Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P52170
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P52170-F1 | Predicted | AlphaFoldDB |
No variants for P52170
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P52170 | |||||
No associated diseases with P52170
9 regional properties for P52170
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Armadillo | 105 - 188 | IPR000225-1 |
| repeat | Armadillo | 190 - 231 | IPR000225-2 |
| repeat | Armadillo | 234 - 273 | IPR000225-3 |
| repeat | Armadillo | 275 - 315 | IPR000225-4 |
| repeat | Armadillo | 317 - 357 | IPR000225-5 |
| repeat | Armadillo | 359 - 399 | IPR000225-6 |
| repeat | Armadillo | 402 - 442 | IPR000225-7 |
| domain | Importin-alpha, importin-beta-binding domain | 1 - 95 | IPR002652 |
| repeat | Atypical Arm repeat | 451 - 501 | IPR032413 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTTNEADER | MRKFKNKGKD | TAELRRRRVE | VSVELRKAKK | DEQILKRRNV | CLPEELILSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKNAMQSVQV | PPLSLEEIVQ | GMNSGDPENE | LRCTQAARKM | LSRERNPPLN | DIIEAGLIPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVEFLSRHDN | STLQFEAAWA | LTNIASGTSD | QTKSVVDGGA | IPAFISLISS | PHLHISEQAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WALGNIAGDG | PLYRDALINC | NVIPPLLALV | NPQTPLGYLR | NITWMLSNLC | RNKNPYPPMS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVLQILPVLT | QLMHHDDKDI | LSDTCWAMSY | LTDGSNDRID | VVVKTGIVDR | LIQLMYSPEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIVTPSLRTV | GNIVTGTDKQ | TQAAIDAGVL | SVLPQLLRHQ | KPSIQKEAAW | AISNIAAGPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PQIQQMITCG | LLSPLVDLLN | KGDFKAQKEA | VWAVTNYTSG | GTVEQVVQLV | QCGVLEPLLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLTIKDSKTI | LVILDAISNI | FLAAEKLGEQ | EKLCLLVEEL | GGLEKIEALQ | THDNHMVYHA |
| 490 | 500 | 510 | 520 | ||
| ALALIEKYFS | GEEADDIALE | PEMGKDAYTF | QVPNMQKESF | NF |