P51976
Gene name |
HSD11B2 |
Protein name |
11-beta-hydroxysteroid dehydrogenase type 2 |
Names |
11-DH2, 11-beta-HSD2, 11beta-OHSD type 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase |
Species |
Oryctolagus cuniculus (Rabbit) |
KEGG Pathway |
ocu:100009531 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51976
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51976-F1 | Predicted | AlphaFoldDB |
No variants for P51976
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51976 | |||||
No associated diseases with P51976
1 regional properties for P51976
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Short-chain dehydrogenase/reductase, conserved site | 219 - 247 | IPR020904 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| 11-beta-hydroxysteroid dehydrogenase (NAD+) activity | Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERWPWPSGG | AWLLVAARAL | IQLLRADLRL | GRPLLAALAL | LAALDWLCQS | LLPPSAALAV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAAAGWIALS | RLARPQRLPV | ATRAVLITGC | DSGFGKETAK | KLDAMGFTVL | ATVLEMNGPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALELRACCSP | RLKLLQMDLT | KPADISRALE | FTKAHTTSTG | LWGLVNNAGH | NDVVADVELS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVATFRNCME | VNFFGALELT | KGLLPLLHHS | RGRIVTLGSP | AGEMPYPCLA | AYGTSKAAMA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLMDAFSCEL | LPWGVKVSVI | QPGCFKTESV | SNVSHWEQRK | QLLLANLPGE | LRQAYGEDYI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EHLHREFLHS | LRLALPDLSP | VVDAITDALL | AARPRPRYYP | GRGLGLMYFI | HYYLPEGLRR |
| 370 | 380 | 390 | 400 | ||
| RFLQSFFIIP | CLPRALRPGQ | PGATPAPDTA | QDNPNPNPDP | SLVGAR |