AiPD: Autoinhibited Protein Database

P51854

Gene name	TKTL1 (TKR, TKT2)
Protein name	Transketolase-like protein 1
Names	Transketolase 2, TK 2, Transketolase-related protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8277
EC number	2.2.1.1: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-52 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P51854

Entry ID	Method	Resolution	Chain	Position	Source
AF-P51854-F1	Predicted				AlphaFoldDB

465 variants for P51854

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10559177 rs782095901	2	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA415143982 rs1557164188	3	D>Y		No	ClinGen gnomAD
rs1381764870 CA415143995	4	A>P		No	ClinGen TOPMed gnomAD
CA415143994 rs1381764870	4	A>S		No	ClinGen TOPMed gnomAD
rs782070940 CA10559179	4	A>V		No	ClinGen ExAC gnomAD
rs371613816 CA10559182	6	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1557164197 CA415144068	7	R>S		No	ClinGen gnomAD
CA10559184 rs781885089	8	A>T		No	ClinGen ExAC gnomAD
RCV000959744 CA10559185 rs147356870	8	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10559187 rs781822420	11	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs983310656 CA337272707	11	P>S		No	ClinGen TOPMed gnomAD
rs781878559 CA10559190	12	E>D		No	ClinGen ExAC gnomAD
rs782542740 CA10559191	13	E>A		No	ClinGen ExAC gnomAD
rs782185508 CA10559193	14	A>D		No	ClinGen ExAC TOPMed gnomAD
CA10559192 rs782689404	14	A>T		No	ClinGen ExAC TOPMed gnomAD
rs868909853 CA415144249	15	R>G		No	ClinGen TOPMed gnomAD
CA337272742 rs199619974	15	R>K		No	ClinGen TOPMed
CA10559194 rs782328350	16	P>L		No	ClinGen ExAC TOPMed gnomAD
CA415144390 rs879988731	17	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	17	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782217671 CA10559196	18	R>G		No	ClinGen ExAC gnomAD
rs782370876 CA415144411	18	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10559198 rs781999622 COSM2155310	18	R>S	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10559197 rs782370876	18	R>T		No	ClinGen ExAC gnomAD
rs1557164245 CA415144441	19	G>D		No	ClinGen gnomAD
CA10559199 rs782146985	19	G>S		No	ClinGen ExAC gnomAD
rs1557164248 CA415144447	20	T>A		No	ClinGen gnomAD
rs1557164249 CA415144456	20	T>I		No	ClinGen gnomAD
CA10559201 rs781918507	21	L>F		No	ClinGen ExAC gnomAD
rs1557164264 CA415144542	23	V>E		No	ClinGen gnomAD
rs1557164262 CA415144532	23	V>L		No	ClinGen gnomAD
TCGA novel	23	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs17855509 VAR_029867 CA415144577	24	L>F		No	ClinGen UniProt Ensembl dbSNP
rs781854800 CA10559204	25	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA415144585 rs1603350084	25	Q>P		No	ClinGen Ensembl
CA415144709 rs1557164276	27	M>I		No	ClinGen gnomAD
rs782798441 CA10559207	27	M>R		No	ClinGen ExAC TOPMed gnomAD
rs782798441 CA10559206	27	M>T		No	ClinGen ExAC TOPMed gnomAD
CA415144698 rs1557164272	27	M>V		No	ClinGen gnomAD
TCGA novel	29	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782736371 CA10559209	29	S>N		No	ClinGen ExAC gnomAD
CA415144773 rs1557164281 CA415144772	29	S>R		No	ClinGen gnomAD
CA10559210 rs781826654	30	R>H	Variant assessed as Somatic; 6.254e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	33	I>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10559211 rs782491545	33	I>M		No	ClinGen ExAC gnomAD
CA10559213 rs782259760	34	H>L		No	ClinGen ExAC TOPMed gnomAD
rs782618468 CA10559212	34	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782538169 CA10559214	35	S>C		No	ClinGen 1000Genomes ExAC gnomAD
CA415144934 rs782538169	35	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA415144940 rs1391040840	36	I>V		No	ClinGen TOPMed
CA415144964 rs1557164303	37	R>G		No	ClinGen gnomAD
rs146955770 COSM108472 CA337272852	37	R>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA415144978 rs1603350099	37	R>S		No	ClinGen Ensembl
CA10559216 rs146955770	37	R>T		No	ClinGen ExAC gnomAD
CA10559217 rs782327304	38	A>G		No	ClinGen ExAC gnomAD
CA415145029 rs1603350102	39	T>A		No	ClinGen Ensembl
rs781972410 CA10559218	41	S>C		No	ClinGen ExAC gnomAD
CA10559219 rs142166417	42	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1557164315 CA415145115	42	T>P		No	ClinGen gnomAD
COSM72986 CA415145165 rs782018424	43	S>N	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10559221 rs782018424	43	S>T		No	ClinGen ExAC gnomAD
rs782172005 CA10559222	44	S>A		No	ClinGen ExAC gnomAD
COSM216187 rs1420946321 CA415148686	50	C>R	NS [Cosmic]	No	ClinGen cosmic curated TOPMed
CA415148702 rs1165720668	50	C>Y		No	ClinGen TOPMed gnomAD
rs782170323 CA10559290	53	S>C		No	ClinGen ExAC
rs1474870214 CA415148988	59	V>A		No	ClinGen TOPMed
CA415149017 rs782317545	61	F>L		No	ClinGen ExAC gnomAD
rs781944208 CA10559292 COSM1117853	62	F>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA10559293 rs782086049	63	Y>C		No	ClinGen ExAC gnomAD
CA415149133 rs1557167015	64	I>V		No	ClinGen gnomAD
rs1557167017 CA415149174	65	M>L		No	ClinGen gnomAD
rs781991070 CA10559295	68	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10559296 rs151187522	69	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	69	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781924988 CA337276713	71	D>H		No	ClinGen TOPMed
rs781924988 CA415149445	71	D>Y		No	ClinGen TOPMed
rs375925960 CA10559297	75	P>L		No	ClinGen ESP ExAC gnomAD
rs1557167029 CA415149660	76	D>Y		No	ClinGen gnomAD
rs1439557057 CA415149820	80	F>L		No	ClinGen TOPMed
CA415149887 rs1557167033	82	L>V		No	ClinGen gnomAD
rs1195344511 CA415149947	83	A>G		No	ClinGen TOPMed
rs1557167035 CA415149936	83	A>S		No	ClinGen gnomAD
rs1557167035 CA415149928	83	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1345934531 CA415149976	84	K>R		No	ClinGen TOPMed
TCGA novel	86	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	87	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557167815 CA415151521	87	S>W		No	ClinGen gnomAD
CA10559321 rs782804391	89	V>A		No	ClinGen ExAC gnomAD
CA415151555 rs1489957294	89	V>M		No	ClinGen TOPMed gnomAD
rs1038567280 CA337277892	92	A>G		No	ClinGen gnomAD
CA415151613 rs1557167825	92	A>T		No	ClinGen gnomAD
rs1038567280 CA415151618	92	A>V		No	ClinGen gnomAD
CA10559322 rs781793127	93	T>I		No	ClinGen ExAC gnomAD
rs782459709 CA10559323	95	W>C		No	ClinGen ExAC gnomAD
CA337277898 rs1049437959	97	G>A		No	ClinGen Ensembl
rs782237883 CA10559325 COSM673984	97	G>R	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10559326 rs199531907	98	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415151792 rs1250150739	98	Q>R		No	ClinGen TOPMed gnomAD
CA415151814 rs1557167844	99	G>A		No	ClinGen gnomAD
CA10559328 rs782265633	99	G>R		No	ClinGen ExAC TOPMed gnomAD
rs139206883 CA10559331	106	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557167853 CA415152170	109	T>A		No	ClinGen gnomAD
CA10559332 rs782339288	109	T>I		No	ClinGen ExAC
CA415152254 rs1557167855	111	K>R		No	ClinGen gnomAD
TCGA novel	115	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415153120 rs1224448043	124	M>V		No	ClinGen TOPMed
CA10559349 rs782226756	125	S>G		No	ClinGen ExAC TOPMed gnomAD
rs782371916 CA10559350	126	D>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	129	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415153380 rs1292282707	130	S>L		No	ClinGen TOPMed gnomAD
CA10559351 rs782650700	131	E>K		No	ClinGen ExAC gnomAD
CA10559352 rs782280549	134	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10559354 rs781937132	135	W>C		No	ClinGen ExAC gnomAD
TCGA novel	138	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415153561 rs1557168175	138	M>V		No	ClinGen gnomAD
rs1557168176 CA415153600	139	A>V		No	ClinGen gnomAD
CA415153688 rs1569550923	142	S>C		No	ClinGen Ensembl
CA10559355 rs782085002	143	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA337278230 rs917091206	144	Y>N		No	ClinGen Ensembl
TCGA novel	145	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	149	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	151	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782358374 CA10559356	151	A>V		No	ClinGen ExAC TOPMed gnomAD
VAR_029868 CA415153929 rs17852259	152	I>T		No	ClinGen UniProt Ensembl dbSNP
rs146510737 CA10559358	152	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA415153989 rs781896350	154	D>E		No	ClinGen ExAC TOPMed gnomAD
CA415153994 rs1431215331	155	V>M		No	ClinGen TOPMed gnomAD
rs782722253 CA10559362	156	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10559363 rs782795411	157	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10559364 rs782493362	163	A>V		No	ClinGen ExAC gnomAD
rs889347298 CA337278256	165	P>A		No	ClinGen Ensembl
CA10559367 rs184120989	166	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10559369 rs782199950	167	E>D		No	ClinGen ExAC TOPMed gnomAD
CA10559370 rs74546727	168	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415154235 rs1219027733	168	H>Y		No	ClinGen TOPMed gnomAD
CA415154255 rs1557168216	169	C>R		No	ClinGen gnomAD
rs367675006 CA10559371	170	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs782236245 CA10559372	171	N>Y		No	ClinGen ExAC gnomAD
rs782388747 CA10559373	173	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1397582869 CA415154398	176	R>H		No	ClinGen TOPMed
rs782635972 CA10559391	183	N>K		No	ClinGen ExAC TOPMed gnomAD
CA415155381 rs1465344859	184	T>S		No	ClinGen TOPMed gnomAD
CA415155393 rs782452162	185	Y>F		No	ClinGen TOPMed
rs782452162 CA337278284	185	Y>S		No	ClinGen TOPMed
CA10559394 rs782577696	190	R>W		No	ClinGen ExAC gnomAD
CA415155548 rs1446527811	192	V>M		No	ClinGen TOPMed gnomAD
CA10559397 TCGA novel rs781977734	199	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
CA415155869 rs782244565	199	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1244241621 CA415155962	202	A>S		No	ClinGen TOPMed
rs1557168266 CA415156033	203	S>F		No	ClinGen gnomAD
CA415156106 rs1214935929 CA415156110	206	K>N		No	ClinGen TOPMed gnomAD
rs1353562265 CA415156271	212	V>L		No	ClinGen TOPMed gnomAD
CA10559399 rs782397523	215	K>R		No	ClinGen ExAC TOPMed gnomAD
CA415156573 rs1557168281	220	R>L		No	ClinGen gnomAD
CA415156566 rs1557168281	220	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA415156560 rs1557168280	220	R>W		No	ClinGen gnomAD
rs782016685 CA10559400	222	T>I		No	ClinGen ExAC TOPMed gnomAD
rs782161822 CA10559401	224	S>G		No	ClinGen ExAC TOPMed gnomAD
rs782024824 CA10559425	224	S>I		No	ClinGen ExAC gnomAD
CA415157002 rs782024824	224	S>T		No	ClinGen ExAC gnomAD
rs1557168570 CA415157022	225	I>S		No	ClinGen gnomAD
TCGA novel	226	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369920575 CA10559426	226	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557168579 CA415157087	227	D>G		No	ClinGen gnomAD
rs143775860 CA10559427	227	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	228	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415157134 rs781829899	229	E>A		No	ClinGen ExAC gnomAD
CA415157138 rs781829899	229	E>G		No	ClinGen ExAC gnomAD
rs781829899 CA10559428	229	E>V		No	ClinGen ExAC gnomAD
TCGA novel	230	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1045929125 CA337278704	230	S>G		No	ClinGen gnomAD
CA415157149 rs1341325455	230	S>N		No	ClinGen TOPMed
TCGA novel	232	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs918916314 CA337278707	232	H>Y		No	ClinGen TOPMed
rs782107839 CA10559429	233	A>T		No	ClinGen ExAC gnomAD
rs782766601 CA10559430	234	K>R		No	ClinGen ExAC gnomAD
rs1557168587 CA415157231	235	P>A		No	ClinGen gnomAD
CA10559431 rs781874134	237	P>S		No	ClinGen ExAC gnomAD
TCGA novel	239	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10559434 rs781791468	241	A>G		No	ClinGen ExAC gnomAD
rs781791468 CA415157459	241	A>V		No	ClinGen ExAC gnomAD
CA415157544 rs1381676579	245	I>M		No	ClinGen TOPMed gnomAD
rs1557168594 CA415157528	245	I>V		No	ClinGen gnomAD
CA337278720 rs1048737670	246	K>R		No	ClinGen gnomAD
TCGA novel	247	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557168602 CA415157697	252	I>L		No	ClinGen gnomAD
CA10559435 rs141938475	252	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA415157748 rs1469272423	254	T>S		No	ClinGen TOPMed
rs782388015 CA10559438	256	R>K		No	ClinGen ExAC TOPMed gnomAD
CA10559437 rs782243133	256	R>W		No	ClinGen ExAC gnomAD
CA415157815 rs1557168610	257	N>D		No	ClinGen gnomAD
CA415157838 rs1557168612	258	L>F		No	ClinGen gnomAD
TCGA novel	258	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782597025 CA337278723	260	P>R		No	ClinGen Ensembl
TCGA novel	264	I>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415158055 CA10559439 rs782663705	266	D>E		No	ClinGen ExAC TOPMed gnomAD
CA10559440 rs146912512	268	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781926826 CA10559443	268	P>H		No	ClinGen ExAC gnomAD
CA415158085 rs781926826	268	P>L		No	ClinGen ExAC gnomAD
rs781926826 CA10559442	268	P>R		No	ClinGen ExAC gnomAD
CA415158080 rs146912512	268	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146912512 CA10559441	268	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782370089 CA415158155	271	N>S		No	ClinGen ExAC TOPMed gnomAD
rs782370089 CA10559444	271	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1557168632 CA415158204	272	I>M		No	ClinGen gnomAD
rs782799253 CA10559448	278	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1557168640 CA415158297	278	T>S		No	ClinGen gnomAD
rs781907217 CA10559449	280	P>L		No	ClinGen ExAC gnomAD
TCGA novel	280	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557168642 CA415158345	281	P>S		No	ClinGen gnomAD
rs782123856 CA10559450	282	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA10559451 rs372729512	283	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA415158408 rs1243055165	284	R>T		No	ClinGen TOPMed
rs781838385 CA10559452	285	V>I		No	ClinGen ExAC gnomAD
CA10559453 rs782494853	288	K>E		No	ClinGen ExAC gnomAD
rs782494853 CA415158495	288	K>Q		No	ClinGen ExAC gnomAD
CA415158790 rs1569550978	289	I>M		No	ClinGen Ensembl
rs782143037 CA10559472	289	I>T		No	ClinGen ExAC gnomAD
CA415158782 rs1557169092	289	I>V		No	ClinGen TOPMed gnomAD
rs373153456 CA10559473	290	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA337279618 rs369349507	290	A>T		No	ClinGen ESP TOPMed
rs1160687358 CA415158801	291	T>A		No	ClinGen TOPMed
rs1557169100 CA415158823	292	R>Q		No	ClinGen gnomAD
rs1471869483 CA415158834	293	K>E		No	ClinGen TOPMed gnomAD
rs1251792445 CA415158895	295	C>G		No	ClinGen TOPMed
CA415158934 rs1485751070	296	G>A		No	ClinGen TOPMed
CA10559475 rs139349276	296	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs782724766 CA10559476	298	A>G		No	ClinGen ExAC TOPMed gnomAD
CA415158969 rs782724766	298	A>V		No	ClinGen ExAC TOPMed gnomAD
CA337279623 rs981926497	300	A>V		No	ClinGen TOPMed gnomAD
CA10559477 rs782149533	303	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA10559479 rs782663073	305	A>E		No	ClinGen ExAC TOPMed gnomAD
COSM206647 CA415159731 rs1284644224	305	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA415159734 rs782663073	305	A>V		No	ClinGen ExAC TOPMed gnomAD
rs782566318 CA10559481	306	N>S		No	ClinGen ExAC gnomAD
CA10559483 rs782199713	307	N>K		No	ClinGen ExAC gnomAD
rs782573359 CA10559482	307	N>S		No	ClinGen ExAC gnomAD
CA10559485 rs782811019 COSM3033807	310	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200876561 CA10559487	312	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1447524488 CA415159793	313	D>E		No	ClinGen TOPMed
CA415159789 rs1557169119	313	D>G		No	ClinGen gnomAD
rs1557169119 CA415159786	313	D>V		No	ClinGen gnomAD
CA415159801 rs1346036626	314	G>A		No	ClinGen TOPMed
CA415159805 rs782041727	315	D>H		No	ClinGen ExAC TOPMed gnomAD
CA10559489 COSM76737 rs782041727	315	D>N	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10559491 rs782710345	316	T>I		No	ClinGen ExAC gnomAD
CA10559490 rs782710345	316	T>S		No	ClinGen ExAC gnomAD
CA10559492 VAR_087456 rs111811311	317	R>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1411867582 CA415159840 CA415159839	317	R>S		No	ClinGen TOPMed gnomAD
rs983313024 CA337279648	318	Y>H		No	ClinGen TOPMed gnomAD
rs983313024 CA415159842	318	Y>N		No	ClinGen TOPMed gnomAD
CA415159856 rs781880487	319	S>C		No	ClinGen ExAC gnomAD
rs781880487 CA415159863	319	S>F		No	ClinGen ExAC gnomAD
rs782771939 CA10559493	319	S>T		No	ClinGen ExAC gnomAD
rs781880487 CA10559494	319	S>Y		No	ClinGen ExAC gnomAD
CA10559495 rs192663483	320	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs147127153 CA10559496	320	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1179635832 CA415159877	321	F>L		No	ClinGen TOPMed
CA10559498 rs370220971	321	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs781793466 CA10559497	321	F>S		No	ClinGen ExAC gnomAD
CA415159883 rs781793466	321	F>Y		No	ClinGen ExAC gnomAD
TCGA novel	322	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	322	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415159922 rs1210323293	323	E>D		No	ClinGen TOPMed
rs975423508 CA337279659	324	I>M		No	ClinGen TOPMed
rs149261694 CA10559500	326	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA415159972 rs782520963	326	N>I		No	ClinGen ExAC gnomAD
rs782520963 CA10559501	326	N>S		No	ClinGen ExAC gnomAD
rs374193459 CA10559502	327	K>E		No	ClinGen ESP ExAC gnomAD
CA415159988 rs1557169146	327	K>M		No	ClinGen gnomAD
rs781854252 CA10559503	330	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs921494097 CA337279665	332	R>C		No	ClinGen Ensembl
CA10559504 rs782301272	332	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1557169152 CA415160134	334	I>L		No	ClinGen gnomAD
CA10559507 rs782353315	335	E>K		No	ClinGen ExAC TOPMed gnomAD
rs782353315 CA415160169	335	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA415160198 rs1557169158	336	C>S		No	ClinGen gnomAD
CA415160233 rs1362884172	338	M>T		No	ClinGen TOPMed
rs924813256 CA337279685	338	M>V		No	ClinGen Ensembl
CA10559509 rs200827513	339	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10559508 rs781989990	339	A>S		No	ClinGen ExAC gnomAD
CA337279696 rs200827513	339	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1557169170 CA415160341	342	N>S		No	ClinGen gnomAD
rs782732237 CA10559513	343	M>I		No	ClinGen ExAC gnomAD
CA10559512 rs782048391	343	M>T		No	ClinGen ExAC gnomAD
rs782039078 CA10559511	343	M>V		No	ClinGen ExAC TOPMed gnomAD
CA415162150 rs1557170435	344	V>L		No	ClinGen gnomAD
rs183077063 CA337281948	345	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
CA415162211 rs372864317 CA415162206	346	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA10559530 rs372864317	346	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1557170444 CA415162230	347	A>T		No	ClinGen gnomAD
CA10559533 rs782001064	351	A>V		No	ClinGen ExAC TOPMed gnomAD
CA415162345 rs1557170452	352	S>C		No	ClinGen TOPMed
CA10559534 rs782148972	353	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782224361 CA10559535	353	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781917493 CA10559536	356	T>I		No	ClinGen ExAC
CA10559537 rs377204314	357	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs782740394 CA10559538	358	A>V		No	ClinGen ExAC gnomAD
rs1557170468 CA415162599	360	A>S		No	ClinGen gnomAD
rs781830344 CA10559539	360	A>V		No	ClinGen ExAC TOPMed gnomAD
rs782571242 CA10559540	361	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs782342823 CA337281986	363	F>C		No	ClinGen gnomAD
rs369823381 CA10559541	363	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1387308417 CA415162742	364	A>G		No	ClinGen TOPMed
rs1557170484 CA415162721	364	A>T		No	ClinGen gnomAD
CA415162762 rs1462748044	365	A>D		No	ClinGen TOPMed
CA415162747 rs1165174197	365	A>T		No	ClinGen TOPMed
CA10559544 rs144486560	368	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA10559545 rs782297564	368	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1557170505 CA415162850	369	R>G		No	ClinGen gnomAD
rs192912565 CA10559546	369	R>Q	Variant assessed as Somatic; 0.00025 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA415162878 rs1557170516	370	A>G		No	ClinGen gnomAD
rs782242540 CA10559548	370	A>S		No	ClinGen ExAC gnomAD
CA415163018 rs1464480791	372	D>G		No	ClinGen TOPMed
CA415162958 rs1557170520	372	D>N		No	ClinGen gnomAD
rs1273933181 CA415163030	373	H>D		No	ClinGen TOPMed gnomAD
rs1557170527 CA415163050	373	H>R		No	ClinGen gnomAD
rs199975610 CA337282026	374	I>M		No	ClinGen TOPMed
rs1215785812 CA415163066	374	I>V		No	ClinGen TOPMed gnomAD
COSM1229331 rs782030512 CA10559550	375	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs201125069 COSM72987 CA337282037	377	G>A	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA415163265 rs782327141	378	G>A		No	ClinGen ExAC TOPMed gnomAD
CA10559552 rs782327141	378	G>V		No	ClinGen ExAC TOPMed gnomAD
CA415163290 rs201452569	380	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10559553 rs201452569	380	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1557170547 CA415163349	381	E>K		No	ClinGen gnomAD
rs782096714 CA10559554	382	S>N		No	ClinGen ExAC gnomAD
rs782747694 CA10559555	383	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10559556 rs782008636	384	I>V		No	ClinGen ExAC gnomAD
CA415163736 rs1391739554	390	H>Q		No	ClinGen TOPMed
CA10559557 rs375728679	390	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs372054381 CA337282078	393	V>L		No	ClinGen ESP gnomAD
rs782820168 CA10559558	394	S>F		No	ClinGen ExAC TOPMed gnomAD
rs782454609 CA10559560	395	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10559585 rs782610669	396	G>D		No	ClinGen ExAC gnomAD
rs782516762 CA10559587	399	G>A		No	ClinGen ExAC gnomAD
CA10559588 rs782672188	402	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA10559589 rs782301914	402	Q>H		No	ClinGen ExAC gnomAD
CA415164714 rs1223233989	404	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	406	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415164803 rs1557171263	406	E>G		No	ClinGen gnomAD
CA337282689 rs782556342	408	I>V		No	ClinGen Ensembl
TCGA novel	409	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415165000 rs1290728171	410	M>T		No	ClinGen TOPMed
rs1330289327 CA415164976	410	M>V		No	ClinGen TOPMed
CA415165112 rs1222633627	413	T>S		No	ClinGen TOPMed
rs1057352244 CA337282696	416	K>E		No	ClinGen gnomAD
rs142614631 CA10559592	418	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA415165270 rs1557171270	419	I>V		No	ClinGen gnomAD
CA415165304 rs1557171272	420	F>I		No	ClinGen gnomAD
rs782611870 CA10559596	421	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA415165373 rs1389181913	423	T>A		No	ClinGen TOPMed gnomAD
CA10559597 rs781919767	423	T>I		No	ClinGen ExAC gnomAD
CA10559599 rs782721129	425	A>T		No	ClinGen ExAC gnomAD
rs200090213 CA10559601	426	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782774728 CA10559602	427	S>T		No	ClinGen ExAC gnomAD
CA10559603 rs191591693	428	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415165592 rs781992606	430	H>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781992606 CA10559605	430	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10559606 rs782232261	432	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs143592962 CA10559607	433	A>G		No	ClinGen ESP ExAC
rs782610528 CA10559608	435	A>P		No	ClinGen ExAC gnomAD
CA10559609 rs782346636	437	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA10559610 rs146779031	438	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA10559611 rs146779031	438	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781864611 CA10559638	440	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415167182 rs1196550783	441	M>I		No	ClinGen TOPMed
rs936805186 CA337283480	441	M>V		No	ClinGen TOPMed gnomAD
rs781964116 CA10559641	444	I>V		No	ClinGen ExAC gnomAD
CA10559642 rs782108113	447	T>A		No	ClinGen ExAC TOPMed gnomAD
rs371034985 CA10559645	448	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371034985 CA10559644	448	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA10559646 rs140507131	451	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA415167370 rs1557171724	451	T>S		No	ClinGen gnomAD
CA415167380 rs1300685684	452	M>T		No	ClinGen TOPMed
CA10559647 rs781801003	452	M>V		No	ClinGen ExAC gnomAD
CA415167501 rs782747271	457	P>A		No	ClinGen ExAC TOPMed gnomAD
rs782747271 CA10559649	457	P>S		No	ClinGen ExAC TOPMed gnomAD
rs782621324 CA10559651	460	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs782667299 CA10559652	460	R>H		No	ClinGen ExAC TOPMed gnomAD
CA415167641 rs370025375	463	I>M		No	ClinGen gnomAD
CA10559654 rs782445587	466	A>G		No	ClinGen ExAC gnomAD
CA10559699 rs782538374	470	R>C		No	ClinGen ExAC gnomAD
CA10559700 rs782677354	472	C>Y		No	ClinGen ExAC gnomAD
rs1376216820 CA415168843	473	V>G		No	ClinGen TOPMed
rs1299359221 CA415168850	474	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs782177823 CA10559701	477	V>I		No	ClinGen ExAC TOPMed
rs782322974 CA10559702	478	T>A		No	ClinGen ExAC gnomAD
CA10559703 rs781955545	480	I>V		No	ClinGen ExAC gnomAD
rs1557172241 CA415169101	485	T>S		No	ClinGen gnomAD
TCGA novel	489	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557172245 CA415169337	495	E>K		No	ClinGen gnomAD
rs782175414 CA337284342	497	S>L		No	ClinGen gnomAD
CA10559706 rs782008861	498	K>R		No	ClinGen ExAC gnomAD
CA10559720 rs376278544	501	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	502	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337284398 rs782716102	502	F>S		No	ClinGen 1000Genomes
CA10559722 rs782491397	504	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782641231 CA415169787	506	I>M		No	ClinGen ExAC gnomAD
CA415169841 rs1238902969	508	L>P		No	ClinGen TOPMed gnomAD
CA10559724 rs782265228	511	I>V		No	ClinGen ExAC gnomAD
rs201077880 CA10559725	512	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10559726 rs782032377	516	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA415170005 rs1557172314	517	A>T		No	ClinGen gnomAD
CA415170014 rs1557172316	517	A>V		No	ClinGen gnomAD
CA10559730 rs199581980	518	T>I		No	ClinGen ExAC TOPMed gnomAD
CA415170045 rs1557172325	519	I>V		No	ClinGen gnomAD
TCGA novel	520	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10559732 rs782017163	520	V>I		No	ClinGen ExAC gnomAD
CA415170155 rs1557172329	522	S>N		No	ClinGen gnomAD
rs782698965 CA10559734	525	A>V		No	ClinGen ExAC gnomAD
rs1557172332 CA415170255	526	T>A		No	ClinGen gnomAD
CA10559735 rs781802203 COSM1117873	529	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs146749788 CA10559736	531	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557172343 CA415170418	532	T>I		No	ClinGen gnomAD
rs782370507 CA10559738	537	Y>H		No	ClinGen ExAC gnomAD
rs373103609 CA337284499	538	P>L		No	ClinGen ESP TOPMed gnomAD
rs1557172718 CA415171000	542	I>V		No	ClinGen gnomAD
CA415171040 rs1557172725	543	G>R		No	ClinGen gnomAD
CA415171132 rs782124719	547	C>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10559756 rs199544899	548	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA10559758 rs782707094	549	A>S		No	ClinGen ExAC gnomAD
CA10559757 rs782707094	549	A>T		No	ClinGen ExAC gnomAD
TCGA novel	549	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146609649 CA10559760	550	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	551	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415171223 rs1557172746	552	M>I		No	ClinGen gnomAD
CA337285497 rs989038019	552	M>T		No	ClinGen gnomAD
rs781865919 CA10559761	554	P>R		No	ClinGen ExAC gnomAD
rs1350572321 CA415171303	556	I>V		No	ClinGen TOPMed
CA415171374 rs1557172751	559	H>Q		No	ClinGen gnomAD
CA10559763 rs782676053	559	H>R		No	ClinGen ExAC gnomAD
CA10559762 COSM1715860 rs782531190	559	H>Y	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs185709468 CA337285504	560	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed
rs1369673325 CA415171393	561	L>M		No	ClinGen TOPMed
rs782327341 CA10559765	563	V>A		No	ClinGen ExAC gnomAD
CA337285537 COSM1229332 rs913505109	564	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
CA10559767 rs371201153	565	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557172763 CA415171466	565	G>R		No	ClinGen gnomAD
CA10559768 rs782382478	566	V>M		No	ClinGen ExAC
CA10559769 rs782002162	567	P>S		No	ClinGen ExAC TOPMed gnomAD
rs782002162 CA415171491	567	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1175446850 CA415171521	568	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1557172775 CA415171541	569	S>I		No	ClinGen gnomAD
CA10559770 rs782152120	570	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10559772 rs781929252	573	E>K		No	ClinGen ExAC gnomAD
CA415171691 rs1557172787	576	L>M		No	ClinGen gnomAD
CA415171692 rs1557172787	576	L>V		No	ClinGen gnomAD
CA415171775 rs1482558404	578	M>I		No	ClinGen TOPMed
rs1184017743 CA415171735	578	M>V		No	ClinGen TOPMed
rs782795651 CA10559773	579	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs782727367 CA10559774	582	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1209918547 CA415171882	582	S>T		No	ClinGen TOPMed
CA415171902 rs1557172799	583	A>T		No	ClinGen gnomAD
rs782122038 CA10559776	584	R>S		No	ClinGen ExAC gnomAD
CA337285605 rs368579797	587	I>T		No	ClinGen ESP TOPMed gnomAD
rs1226155021 CA415172017	588	V>A		No	ClinGen TOPMed
rs1557172807 CA415172002	588	V>M		No	ClinGen gnomAD
CA415172069 rs1557172811	590	V>G		No	ClinGen gnomAD
rs1313144890 CA415172060	590	V>M		No	ClinGen TOPMed
CA337285611 rs782385349	591	K>R		No	ClinGen gnomAD
rs1557172817 CA415172111	592	C>W		No	ClinGen gnomAD
rs1302136479 CA415172143	593	M>T		No	ClinGen TOPMed
rs190080682 CA10559780	593	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415172183 rs1390879637	595	L>P		No	ClinGen TOPMed

No associated diseases with P51854

4 regional properties for P51854

Type	Name	Position	InterPro Accession
domain	Transketolase, N-terminal	88 - 239	IPR005474
domain	Transketolase-like, pyrimidine-binding domain	288 - 453	IPR005475
binding_site	Transketolase binding site	396 - 412	IPR020826
domain	Transketolase, C-terminal domain	465 - 586	IPR033248

Functions

		Description
EC Number	2.2.1.1	Transketolases and transaldolases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
thiamine pyrophosphate binding	Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
transketolase activity	Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor.

2 GO annotations of biological process

Name	Definition
glucose catabolic process	The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.
thiamine metabolic process	The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MADAEARAEF	PEEARPDRGT	LQVLQDMASR	LRIHSIRATC	STSSGHPTSC	SSSSEIMSVL
70	80	90	100	110	120
FFYIMRYKQS	DPENPDNDRF	VLAKRLSFVD	VATGWLGQGL	GVACGMAYTG	KYFDRASYRV
130	140	150	160	170	180
FCLMSDGESS	EGSVWEAMAF	ASYYSLDNLV	AIFDVNRLGH	SGALPAEHCI	NIYQRRCEAF
190	200	210	220	230	240
GWNTYVVDGR	DVEALCQVFW	QASQVKHKPT	AVVAKTFKGR	GTPSIEDAES	WHAKPMPRER
250	260	270	280	290	300
ADAIIKLIES	QIQTSRNLDP	QPPIEDSPEV	NITDVRMTSP	PDYRVGDKIA	TRKACGLALA
310	320	330	340	350	360
KLGYANNRVV	VLDGDTRYST	FSEIFNKEYP	ERFIECFMAE	QNMVSVALGC	ASRGRTIAFA
370	380	390	400	410	420
STFAAFLTRA	FDHIRIGGLA	ESNINIIGSH	CGVSVGDDGA	SQMALEDIAM	FRTIPKCTIF
430	440	450	460	470	480
YPTDAVSTEH	AVALAANAKG	MCFIRTTRPE	TMVIYTPQER	FEIGQAKVLR	HCVSDKVTVI
490	500	510	520	530	540
GAGITVYEAL	AAADELSKQD	IFIRVIDLFT	IKPLDVATIV	SSAKATEGRI	ITVEDHYPQG
550	560	570	580	590
GIGEAVCAAV	SMDPDIQVHS	LAVSGVPQSG	KSEELLDMYG	ISARHIIVAV	KCMLLN