P51789
Gene name |
CLCN2 |
Protein name |
Chloride channel protein 2 |
Names |
ClC-2, PKA-activated chloride channel |
Species |
Oryctolagus cuniculus (Rabbit) |
KEGG Pathway |
ocu:100009530 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51789
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51789-F1 | Predicted | AlphaFoldDB |
No variants for P51789
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51789 | |||||
No associated diseases with P51789
No regional properties for P51789
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P51789 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| acinar cell differentiation | The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. |
| cell differentiation involved in salivary gland development | The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland. |
| regulation of aldosterone biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPAAAAVE | EGMEPRALQY | EQTLMYGRYT | QDLGAFAKEE | AARIRLGGPE | PWRSPPSPRT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPELLEYGQS | RCARCRMCSV | RCHKFLVSRV | GEDWIFLVLL | GLLMALVSWA | MDYAIAACLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQQWMSRGLN | TNLLLQYLAW | VTYPVVLITF | SAGFTQILAP | QAVGSGIPEM | KTILRGVVLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EYLTLKTFVA | KVIGLTCALG | SGMPLGKEGP | FVHIASMCAA | LLSKFLSLFG | GIYENESRNT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EMLAAACAVG | VGCCFAAPIG | GVLFSIEVTS | TFFAVRNYWR | GFFAATFSAF | IFRVLAVWNR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEETITALFK | TRFRLDFPFD | LQELPAFAVI | GIASGFGGAL | FVYLNRKIVQ | VMRKQKTINR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FLMRKRLLFP | ALVTLLISTL | TFPPGFGQFM | AGQLSQKETL | VTLFDNRTWV | RQGLVEELEP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSTSQAWSPP | RANVFLTLVI | FILMKFWMSA | LATTIPVPCG | AFMPVFVIGA | AFGRLVGESM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AAWFPDGIHT | DSSTYRIVPG | GYAVVGAAAL | AGAVTHTVST | AVIVFELTGQ | IAHILPVMIA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VILANAVAQS | LQPSLYDSII | RIKKLPYLPE | LGWGRHQQYR | VRVEDIMVRD | VPHVALSCTF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RDLRLALHRT | KGRTLALVES | PESMILLGSI | ERTQVVALLA | AQLSPARRRQ | SKQKRRVAHT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SPPSCQESPP | SPETSVCFQV | KAEDAQGEPH | KPLKPALKRG | CSNSVNLGES | PTGHVESAGI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALRSLFCGSP | PPEAASESEK | SESSEKRKSK | RVRISLASDS | DLEGEMSPEE | ILEWEEQQLD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EPVNFSDCKI | DPAPFQLVER | TSLHKTHTIF | SLLGVDHAYV | TSIGRLIGIV | TLKELRKAIE |
| 850 | 860 | 870 | 880 | 890 | |
| GSVTAQGVKV | RPPLASFRDS | ATSSSDTETT | EVHALWGPRS | RHGLPREGSP | SDSDDKCQ |