P51776

PR
Gene name
Protein name
Pyruvate, phosphate dikinase
Names
Pyruvate, orthophosphate dikinase
Species
Giardia intestinalis (Giardia lamblia)
KEGG Pathway
EC number
2.7.9.1: Phosphotransferases with paired acceptors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P51776

Entry ID Method Resolution Chain Position Source
AF-P51776-F1 Predicted AlphaFoldDB

No variants for P51776

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P51776

No associated diseases with P51776

6 regional properties for P51776

Type Name Position InterPro Accession
domain PEP-utilising enzyme, C-terminal 529 - 874 IPR000121
domain Pyruvate phosphate dikinase, AMP/ATP-binding 68 - 297 IPR002192-1
domain Pyruvate phosphate dikinase, AMP/ATP-binding 313 - 367 IPR002192-2
domain PEP-utilising enzyme, mobile domain 431 - 512 IPR008279
active_site PEP-utilising enzyme, active site 459 - 470 IPR018274
conserved_site PEP-utilising enzyme, conserved site 769 - 787 IPR023151

Functions

Description
EC Number 2.7.9.1 Phosphotransferases with paired acceptors
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
pyruvate, phosphate dikinase activity Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTRRVYFFG ETPENQPANS ELCRKVLGGK GISLAAMIKL GMPVPLGFTI TCQTCVEYQK
70 80 90 100 110 120
TASWPKGLKE EVASNLKLLE EKMGKTFGDN TNPLLVSVRS GAAVSMPGMM DTILNLGLND
130 140 150 160 170 180
ESVKGLAAVT GNARFAYDSY RRFMQMFGDV CLGIDHDKFE HALDAVKTRY GRKTDPELTA
190 200 210 220 230 240
DELEEVCEAY RKICVAATGK TFPQCPHEQL ELAINAVFKS WTNPRAQAYR TLNKLDHNMG
250 260 270 280 290 300
TAVNVQSMVF GNTGDDSGTG VGFTRCPKTG EKFSYLYGEF LQNAQGEDVV AGIRTPVNLK
310 320 330 340 350 360
EMPTINASWK ACYDELSLIY AKLEGYYNDM VDLEFTVENG KLWMLQARAG KRTGFAMVRI
370 380 390 400 410 420
AIDMCKEGML TEEEALLRID ANKINEFLFK RFDPSVKPVV LGKGIPASPG AAVGVICFCP
430 440 450 460 470 480
MRTCELAEQG KKVILTRIET SPEDILGMDR AVGILTARGG QTSHAAVVAR GMGKCCVAGA
490 500 510 520 530 540
DCCQINYATK TLVIGDRKFK EGDFISINGT TGEIYNGAVQ TIEPGITDDL QTIMDWSDKY
550 560 570 580 590 600
RVLKIRTNAD TPHDAAVARK FGAEGIGLCR TEHMFFAADR IMAMREMILS DDEGARRTAL
610 620 630 640 650 660
NKLLPFQRED FIGIFKAMDG KGVNIRLLDP PLHEFLPHTR DLQKKLAEDM NKKHRHIHER
670 680 690 700 710 720
VEDLHEVNPM LGFRGVRLGI VYPEISEMQV RAILEAACIV SREGVTVKPE IMIPVLFSEN
730 740 750 760 770 780
EMEIMHALVN RVAASVFKEH GTTVDYEVGT MIELPRACVM ADKIAQTAQY FSFGTNDLTQ
790 800 810 820 830 840
TTFGISRDDA GKFIPKYIDR GIFKVDPFVT LDQQGVGALM KMAIEGGRST RTDMKIGICG
850 860 870 880
EQTDPASILF LHKIGLNYVS CSPYRVPVAR VAAAIAAIKA RTNQ