P51581

PR
Gene name
CYP2E1 (CYP2E)
Protein name
Cytochrome P450 2E1
Names
4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-J
Species
Mesocricetus auratus (Golden hamster)
KEGG Pathway
EC number
1.14.13.n7: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

223-311 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P51581

Entry ID Method Resolution Chain Position Source
AF-P51581-F1 Predicted AlphaFoldDB

No variants for P51581

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P51581

No associated diseases with P51581

1 regional properties for P51581

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 430 - 439 IPR017972

Functions

Description
EC Number 1.14.13.n7 With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein
  • Microsome membrane ; Peripheral membrane protein
  • Mitochondrion inner membrane ; Peripheral membrane protein
  • Post-translationally targeted to mitochondria
  • TOMM70 is required for the translocation across the mitochondrial outer membrane
  • After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

8 GO annotations of molecular function

Name Definition
4-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+).
aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
iron ion binding Binding to an iron (Fe) ion.
long-chain fatty acid omega-1 hydroxylase activity Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized

8 GO annotations of biological process

Name Definition
4-nitrophenol metabolic process The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.
heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
lipid hydroxylation The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
long-chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
monoterpenoid metabolic process The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVFGVTIAL LVWVATLLIV SIWKQIYSSW NLPPGPFPLP ILGNIFQLDL KNIPKSLTKL
70 80 90 100 110 120
AERFGPVFTL HLGSKRIVVL HGYKAVKEVL LNHKNEFSGR GDIPVFQEYM NKGIIFNNGP
130 140 150 160 170 180
TWKDVRRFSL SILRDYGMGK QGNEARIQRE AHFLMEELKK TNGQPFDPTF LVGCAPFNVI
190 200 210 220 230 240
SDILFHKRFD YNDKTCLRLM SLFNENFYLL STPWIQAYNN FENYLRYLPG SHRKIMKNAS
250 260 270 280 290 300
EIRQYTLAKA KEHLQSLDSS CPRDVTDCLL IEMEKEKDSQ EPMYTMENIS VTLADLFFAG
310 320 330 340 350 360
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPSRVPV FKDRLEMPYM DAVVHEIQRF
370 380 390 400 410 420
ISLIPSNLPH EATRDTMFRG YVIPKGTVVI PTLDSLLYDS QEFPDPEKFK PEHFLNENGK
430 440 450 460 470 480
FKYSDHFKAF SAGKRVCVGE GLARMELFLL LTAILQHFNL KSLVDPKDID LNPVTIGFGC
490
VPPEFKLCVI PRS