AiPD: Autoinhibited Protein Database

P51397

Gene name	DAP (DAP1)
Protein name	Death-associated protein 1
Names	DAP-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1611
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-102 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

14-102 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P51397

Entry ID	Method	Resolution	Chain	Position	Source
AF-P51397-F1	Predicted				AlphaFoldDB

93 variants for P51397

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3200195 rs776377093	2	S>P		No	ClinGen ExAC TOPMed gnomAD
CA359274805 rs1365064514	2	S>Y		No	ClinGen gnomAD
CA3200193 rs746530109	4	P>L		No	ClinGen ExAC TOPMed gnomAD
rs985733833 CA114322902	4	P>T		No	ClinGen TOPMed gnomAD
rs1404381469 CA359274790	5	P>H		No	ClinGen gnomAD
CA3200192 rs780067899	5	P>S		No	ClinGen ExAC gnomAD
CA359274783 rs1447389158	6	E>G		No	ClinGen gnomAD
rs1190232707 CA359274786	6	E>K		No	ClinGen gnomAD
CA359274776 rs1194123898	7	G>E		No	ClinGen TOPMed gnomAD
rs1194123898 CA359274774	7	G>V		No	ClinGen TOPMed gnomAD
CA359274773 rs1263758394	8	K>E		No	ClinGen TOPMed gnomAD
rs1160193788	8	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201354802 CA3200188	10	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753961777 CA3200187	10	E>G		No	ClinGen ExAC gnomAD
rs201354802 CA359274760	10	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3200186 rs764316925	11	T>S		No	ClinGen ExAC gnomAD
CA3200185 rs756123267	12	K>*		No	ClinGen ExAC gnomAD
rs369001210 CA3200184	12	K>N		No	ClinGen ESP ExAC gnomAD
rs544175556 CA3200183	13	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3200182 rs760011276	15	H>P		No	ClinGen ExAC gnomAD
CA359274720 rs1302492041	16	P>L		No	ClinGen TOPMed
CA3200166 rs756386770	22	G>V		No	ClinGen ExAC TOPMed gnomAD
rs368335191 CA3200165	24	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3200164 rs767625403	25	R>*		No	ClinGen ExAC gnomAD
rs1226243473 COSM170202 CA359274220	25	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1308225118 CA359274201	27	V>M		No	ClinGen TOPMed
CA3200163 rs375473454	28	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1579821008 CA359274173	29	K>*		No	ClinGen Ensembl
CA3200162 rs751960003	31	P>T		No	ClinGen ExAC gnomAD
rs766923087 CA3200161	32	H>R		No	ClinGen ExAC gnomAD
rs763159353 CA3200160	33	T>I		No	ClinGen ExAC gnomAD
rs773776115 CA3200159	34	G>E		No	ClinGen ExAC gnomAD
rs370687092 CA114321376	36	T>I		No	ClinGen ESP
rs760450361 CA3200157	39	E>D		No	ClinGen ExAC TOPMed gnomAD
CA3200158 rs763820923	39	E>G		No	ClinGen ExAC gnomAD
CA3200156 rs775106618	40	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1189807314 CA359273968	42	K>N		No	ClinGen gnomAD
CA3200155 rs771437354	42	K>R		No	ClinGen ExAC TOPMed gnomAD
rs759102630 COSM1432038 CA3200154	43	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	44	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774093508 CA3200153	45	Q>K		No	ClinGen ExAC gnomAD
rs1206301210 CA359273925	45	Q>R		No	ClinGen gnomAD
CA3200151 rs749069910	48	E>V		No	ClinGen ExAC gnomAD
CA3200149 rs768003567	49	S>G		No	ClinGen ExAC gnomAD
CA3200148 rs768003567	49	S>R		No	ClinGen ExAC gnomAD
CA3200115 rs751003718	52	P>T		No	ClinGen ExAC gnomAD
rs61737757 CA3200114	53	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs969390237 CA114313604	57	V>L		No	ClinGen TOPMed
rs765162227 CA3200111	60	S>Y		No	ClinGen ExAC gnomAD
rs1295915866 CA359274626	62	V>I		No	ClinGen TOPMed
rs148041255 CA3200109	65	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359274606 rs1330540269	65	R>W		No	ClinGen TOPMed gnomAD
rs911762786 CA114313315	66	G>A		No	ClinGen TOPMed
rs911762786 CA359274589	66	G>V		No	ClinGen TOPMed
CA359274584 rs1164445711	67	D>Y		No	ClinGen TOPMed
rs143260700 CA3200089	70	F>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143260700 CA3200090	70	F>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA359274549 rs1403653061	71	P>S		No	ClinGen TOPMed
CA359274537 rs1409337925	72	P>L		No	ClinGen TOPMed gnomAD
rs1473265240 CA359274541	72	P>T		No	ClinGen gnomAD
rs777516488	73	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	73	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772491673 CA3200085	73	A>V		No	ClinGen ExAC TOPMed gnomAD
CA3200083 rs774626270	75	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1579779494 CA359274498	77	V>G		No	ClinGen Ensembl
rs749762915 CA359274492	78	A>P		No	ClinGen ExAC gnomAD
rs749762915 CA3200081	78	A>S		No	ClinGen ExAC gnomAD
CA359274482 rs1579779485	79	H>P		No	ClinGen Ensembl
rs1268640175 CA359274485	79	H>Y		No	ClinGen gnomAD
CA359274474 rs1210693105	80	Q>*		No	ClinGen gnomAD
rs1267746944 CA359274453	82	P>L		No	ClinGen TOPMed gnomAD
CA359274447 rs1381868157	83	H>R		No	ClinGen gnomAD
rs1447995735 CA359274419	86	M>I		No	ClinGen TOPMed gnomAD
rs748465213 CA3200078	86	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA359274415 rs1366601769	87	D>H		No	ClinGen gnomAD
CA359274406 rs1214967189	88	K>E		No	ClinGen TOPMed
rs1323081999 CA359274394	89	H>R		No	ClinGen gnomAD
rs1458372372 CA359274388	90	P>A		No	ClinGen TOPMed gnomAD
CA359274389 rs1458372372	90	P>S		No	ClinGen TOPMed gnomAD
CA114313314 rs200643170	92	P>A		No	ClinGen 1000Genomes
CA359274370 rs1158014201	92	P>Q		No	ClinGen gnomAD
rs1405582820 CA359274360 COSM1486197	93	R>T	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA359274350 rs1367774298	94	T>I		No	ClinGen Ensembl
rs1579779429 CA359274355	94	T>P		No	ClinGen Ensembl
rs749912052 CA3200075	96	H>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel rs957397251 CA114313312	98	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed gnomAD NCI-TCGA
rs1355289118 CA359274295	100	P>L		No	ClinGen TOPMed gnomAD
rs1190354858 CA359274279	101	R>C		No	ClinGen gnomAD
rs756745510 CA3200074	101	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756745510 CA3200073	101	R>L		No	ClinGen ExAC TOPMed gnomAD
CA114313311 rs756745510	101	R>P		No	ClinGen ExAC TOPMed gnomAD
CA359274260 rs1408795576	102	K>R		No	ClinGen TOPMed
TCGA novel	103	K>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P51397

No regional properties for P51397

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P51397

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name	Definition
death domain binding	Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.

8 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
apoptotic signaling pathway	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cellular response to amino acid starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
negative regulation of autophagy	Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of NF-kappaB transcription factor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q91XC8	Dap	Death-associated protein 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSSPPEGKLE	TKAGHPPAVK	AGGMRIVQKH	PHTGDTKEEK	DKDDQEWESP	SPPKPTVFIS
70	80	90	100
GVIARGDKDF	PPAAAQVAHQ	KPHASMDKHP	SPRTQHIQQP	RK