P50979

PR
Gene name
katE
Protein name
Catalase HPII
Names
Species
Mycobacterium avium
KEGG Pathway
EC number
1.11.1.6: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50979

Entry ID Method Resolution Chain Position Source
AF-P50979-F1 Predicted AlphaFoldDB

No variants for P50979

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50979

No associated diseases with P50979

5 regional properties for P50979

Type Name Position InterPro Accession
binding_site Catalase haem-binding site 361 - 369 IPR002226
domain Catalase immune-responsive domain 445 - 508 IPR010582
domain Catalase core domain 30 - 419 IPR011614
active_site Catalase active site 66 - 82 IPR024708
domain Large catalase, C-terminal domain 540 - 699 IPR041399

Functions

Description
EC Number 1.11.1.6 Peroxidases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATDHTSDAP DPKQRDLESA RFRRDTGYLT TQQGVRVDHT DDALTVGERG PTLLEDFHAR
70 80 90 100 110 120
EKITHFDHER IPERVVHARG AGAYGYFEPY DDRLAQYTAA KFLTSPGTRT PVFVRFSTVA
130 140 150 160 170 180
GSRGSADTVR DVRGFATKFY TEQGNYDLVG NNFPVFFIQD GIKFPVLVHA VKPEPHNEIP
190 200 210 220 230 240
QAQSAHDTLW DFVSLQPETL HAIMWLMSDR ALPRSYRMMQ GFGVHTFRLV NARGRGTFVK
250 260 270 280 290 300
FHWKPRLGVH SLIWDECQKI AGKDPDYNRR DLWEAIESGQ YPEWELGVQL VAEDDEFSFD
310 320 330 340 350 360
FDLLDATKII PEEQVPVLPV GKMVLNRNPD NFFAETEQVA FHTANVVPGI DFTNDPLLQF
370 380 390 400 410 420
RNFSYLDTQL IRLGGPNFAQ LPVNRPVAQV RTNQHDGYAQ HAIPQGRSSY FKNSIGGGCP
430 440 450 460 470 480
ALADEDVFRH YTQRVDGQTI GKRAEAFQNH YGQARMFFKS MSPVEAEHIV AAFAFELGKV
490 500 510 520 530 540
EMPEIRSAVV AQLARVDDQL AAQVAAKLGL PEPPEEQVDE SAPVSPALSQ VTDGGDTIAS
550 560 570 580 590 600
RRIAVLAADG VDVVGTQRFT ELMEQRGAVV EVLAPVAGGT LAGGSGGELR VDRSFTTMAS
610 620 630 640 650 660
VLYDAVVVAC GPRSVSTLSD DGYAVHFVTE AYKHLKPIGA YGAGVDLLRK AGIDNRLAED
670 680 690 700
TDVLNDQAVV TTKAAADELP ERFAEEFAAA LAQHRCWQRR TDAVPA