P50763

PR
Gene name
E1
Protein name
Replication protein E1
Names
ATP-dependent helicase E1
Species
Human papillomavirus 28
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

125-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P50763

Entry ID Method Resolution Chain Position Source

No variants for P50763

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50763

No associated diseases with P50763

4 regional properties for P50763

Type Name Position InterPro Accession
domain DNA helicase E1, C-terminal, Papillomavirus 366 - 653 IPR001177
domain DNA helicase E1, N-terminal, Papillomavirus 1 - 141 IPR014000
domain Helicase, superfamily 3, DNA virus 464 - 614 IPR014015
domain DNA helicase E1, DNA-binding domain, papillomavirus 223 - 361 IPR046832

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Host nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDTSGTEGD ECSELERAGG WFMVEAIVDR RTGDKPSSDE DEDEDADEGE DFVDFIDDRP
70 80 90 100 110 120
VGDGQEVAQE LLLQQAAADD DVAVQAVKRK FAPSPYFSPV CMQPSIENEL SPRLDAIKLG
130 140 150 160 170 180
RQSGTAKRRL FQLPDSGYGQ TQVDTESGPL QVQDICETGT QDGRQDADEG SGRNVGGNGG
190 200 210 220 230 240
QEEERAGGDG EESQTQGVQT DKAACGVLAI LRASNQKATL LGKFKEQFGL GFNELIRHFK
250 260 270 280 290 300
SSKTVCLDWV VCVFGVYCTL AEGIKTLIQP QCDYAHIQVL SCQWGMTVLM LVRYKRAKNR
310 320 330 340 350 360
ETVAKGLSTL LNVPESHMLI EPPKLRSGPA ALYWYKTAMS NCSDVYGETP EWIVRQTMVG
370 380 390 400 410 420
HALEEAQFSL SEMVQYAYDH DITDESMLAF EYALLADTDA NAAAFLSSNC QAKYVKDACT
430 440 450 460 470 480
MCRHYKRGEQ ARMNMSEWIW FRGDKVQGDG DWKPIVQFLR YHDVEFIPFL CAFKTFLQGI
490 500 510 520 530 540
PKKSCLVFYG PADTGKSYFC MSLLRFLGGV VISYANSNSH FWLQPLADAK IGLLDDATSQ
550 560 570 580 590 600
CWCYIDTYLR NALDGNQVCI DRKHRALLQL KCPPLLITTN INPLEDDRWK YLRSRVQLFT
610 620 630 640 650 660
FKNKFPLTTQ GEPLYTLNDQ NWKCFFRRLW ARLSLTDPDD EEENGNPSEP FRCVPGQNAR
TL