P50760

PR
Gene name
E1
Protein name
Replication protein E1
Names
ATP-dependent helicase E1
Species
Human papillomavirus 22
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P50760

Entry ID Method Resolution Chain Position Source

No variants for P50760

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50760

No associated diseases with P50760

4 regional properties for P50760

Type Name Position InterPro Accession
domain DNA helicase E1, C-terminal, Papillomavirus 313 - 599 IPR001177
domain DNA helicase E1, N-terminal, Papillomavirus 1 - 125 IPR014000
domain Helicase, superfamily 3, DNA virus 410 - 560 IPR014015
domain DNA helicase E1, DNA-binding domain, papillomavirus 172 - 307 IPR046832

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Host nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDDDKGTDTT DAKEGCSGWF MLEAACSDDS DLDNSLEKLF EDGTESDVSD LINDDDTAAQ
70 80 90 100 110 120
GNSRELLCQQ QSEECEQQIQ YLKRKYFSPK AVQQLSPRLQ SMNISPGHKS KRRLFVEHDS
130 140 150 160 170 180
GLECSLNEAE DLTEEVEVPA SAPAPAAQGG VGSGHYTSLL RCNNVKAVLL GKFKDAFGVS
190 200 210 220 230 240
YNELTRQFRS NKTCCKHWVL AIYAAKDELI DASKQLLQQH CTYLWLQTFS PMSLYLCCFN
250 260 270 280 290 300
VGKSRETVMR LLSSMLQVNE NHILSEPPKI RSMIAALFWY KGSMNPNVYA FGEYPEWIMT
310 320 330 340 350 360
QTMIHHQTAD SVQFDLSEMI QWAYDQDYVD ECTIAYQYAR LADSNSNARA FLAHNSQAKY
370 380 390 400 410 420
VRECAQMVRY YKRGEMRDMS ISAWIHHCIS KIEGDGHWQD IVKFLRYQGL NFIVFLDKFR
430 440 450 460 470 480
TFLKNFPKKN CLLICGPPDT GKSMFSMSLM KALRGQVVSF ANSKSHFWLQ PLADAKLALL
490 500 510 520 530 540
DDATEVCWQY IDAFLRNGLD GNMVSLDMKH RAPCQMKFPP LIITSNISLK KEKKFPYLHS
550 560 570 580 590 600
RIYEFEFPNK FPFDANDTPL FKLTDQSWAS FFKRLWTQLE LSDQEEEGEN GETQRTFQCT
TREVNGLI