AiPD: Autoinhibited Protein Database

P50748

Gene name	KNTC1 (KIAA0166)
Protein name	Kinetochore-associated protein 1
Names	Rough deal homolog, HsROD, Rod, hRod
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9735
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1001-1074 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1001-1074 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P50748

Entry ID	Method	Resolution	Chain	Position	Source
7QPG	EM	390 A	R/S	2-2209	PDB
AF-P50748-F1	Predicted				AlphaFoldDB

1697 variants for P50748

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs267603355 CA244756865 RCV002773501	1254	S>P	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
RCV000205944 CA350033 rs772156434	2209	S>L	Malignant tumor of prostate [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1306686430 CA387048038	2	W>*		No	ClinGen gnomAD
rs770102985 CA6847065	3	N>S		No	ClinGen ExAC TOPMed gnomAD
rs780248943 CA6847066	4	D>N		No	ClinGen ExAC gnomAD
CA6847067 rs556183893	5	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA387048103 rs574708956	6	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA387048085 rs1356725949	6	E>K		No	ClinGen TOPMed gnomAD
rs1356725949 CA387048087	6	E>Q		No	ClinGen TOPMed gnomAD
rs774941412 CA6847069	7	L>M		No	ClinGen ExAC gnomAD
rs1335724258 CA387048132	9	T>A		No	ClinGen TOPMed
CA6847072 rs776265472	9	T>K		No	ClinGen ExAC
CA387048146 rs1274882275	10	N>Y		No	ClinGen TOPMed
rs75209631 CA6847074 CA6847073	11	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847076 rs762674837	13	T>A		No	ClinGen ExAC gnomAD
CA387048213 rs1565922586	13	T>I		No	ClinGen Ensembl
rs61751319 CA6847078	14	G>R		No	ClinGen ExAC TOPMed gnomAD
CA244770389 rs982532025	15	S>T		No	ClinGen TOPMed
rs757242792 CA6847079	16	G>R		No	ClinGen ExAC
CA6847082 rs756177730	21	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1397726585 CA387048354	22	S>L		No	ClinGen gnomAD
CA387048428 rs201024338	26	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6847086 rs201024338	26	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6847087 rs748655836	27	G>E		No	ClinGen ExAC gnomAD
rs772757441 CA6847088	31	Y>C		No	ClinGen ExAC gnomAD
rs775975545 CA6847089	32	Q>E		No	ClinGen ExAC gnomAD
rs61752342 CA6847090	32	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	34	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387048599 rs1309523023	37	V>G		No	ClinGen gnomAD
rs762656292 CA6847093	39	I>T		No	ClinGen ExAC
CA387048648 rs1184407730	40	S>F		No	ClinGen gnomAD
CA244770475 rs894007649	41	S>F		No	ClinGen TOPMed gnomAD
rs1315504340 CA387048677	42	E>G		No	ClinGen gnomAD
CA6847094 rs200159316	43	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	44	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM936245 rs1428064708 CA387049631	44	A>S	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA387049634 rs1287738931	44	A>V		No	ClinGen gnomAD
rs1401820083 CA387049637	45	S>P		No	ClinGen gnomAD
CA244774559 rs890638812	47	N>S		No	ClinGen Ensembl
CA387049688 rs1223823399	49	K>N		No	ClinGen gnomAD
CA387049685 rs1344708529	49	K>R		No	ClinGen gnomAD
CA244774563 rs1010782630	50	I>L		No	ClinGen Ensembl
CA6847114 rs761545034	50	I>T		No	ClinGen ExAC gnomAD
rs192257012 CA244774585	51	Q>R		No	ClinGen 1000Genomes
TCGA novel	52	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387049736 rs1343898991	53	C>*		No	ClinGen TOPMed
CA387049752 rs1215294760	55	L>*		No	ClinGen gnomAD
rs767232160 CA6847116	56	S>N		No	ClinGen ExAC gnomAD
CA387049762 rs184547596	57	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847117 rs184547596	57	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847118 rs61750346	58	G>E		No	ClinGen ExAC TOPMed gnomAD
CA6847119 rs139484580	61	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779777954 CA244774610	63	A>T		No	ClinGen gnomAD
CA244774619 rs1018492342	64	D>N		No	ClinGen TOPMed gnomAD
rs1018492342 CA387049807	64	D>Y		No	ClinGen TOPMed gnomAD
CA387049828 rs1300405349	67	V>L		No	ClinGen gnomAD
CA387049837 rs1360672545	68	I>T		No	ClinGen gnomAD
rs1392308134 CA387049843	69	L>S		No	ClinGen TOPMed
rs144203181 CA6847124	72	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1405350508 CA387049870	73	I>V		No	ClinGen gnomAD
CA6847125 rs758719233	76	S>T		No	ClinGen ExAC gnomAD
CA244774657 rs770442709	79	L>F		No	ClinGen Ensembl
CA387049931 rs1180948984	82	V>D		No	ClinGen Ensembl
rs929827540 CA244774678	82	V>F		No	ClinGen TOPMed gnomAD
CA387050098 rs1249513564	84	D>G		No	ClinGen gnomAD
CA6847147 rs541135571	85	T>A		No	ClinGen ExAC TOPMed gnomAD
CA244777896 rs1004047217	85	T>S		No	ClinGen TOPMed gnomAD
CA387050137 rs778462805	88	D>N		No	ClinGen ExAC gnomAD
rs778462805 CA6847149	88	D>Y		No	ClinGen ExAC gnomAD
CA387050147 rs1384134907	89	V>I		No	ClinGen gnomAD
CA387050163 rs1164939150	90	V>A		No	ClinGen gnomAD
rs1164939150 CA387050161	90	V>D		No	ClinGen gnomAD
CA6847150 rs747823877	90	V>L		No	ClinGen ExAC TOPMed gnomAD
CA387050172 rs771672303	91	G>A		No	ClinGen ExAC gnomAD
rs771672303 CA6847151	91	G>V		No	ClinGen ExAC gnomAD
CA6847153 rs746744152	92	L>P		No	ClinGen ExAC gnomAD
rs770874429 CA6847154	93	C>Y		No	ClinGen ExAC gnomAD
rs776641631 CA6847155	94	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	96	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759611710 CA6847156	96	G>R		No	ClinGen ExAC gnomAD
CA6847157 rs751383353	99	L>P		No	ClinGen ExAC TOPMed gnomAD
CA387050269 rs1268944121	100	L>*		No	ClinGen gnomAD
CA6847158 rs775757438	101	V>I		No	ClinGen ExAC gnomAD
rs1215552863 CA387050284	102	G>V		No	ClinGen gnomAD
CA244778006 rs971928204	103	E>*		No	ClinGen TOPMed gnomAD
rs1593485058 CA387050299	103	E>D		No	ClinGen Ensembl
CA244778005 rs971928204	103	E>K		No	ClinGen TOPMed gnomAD
rs920414911 CA244778011	104	R>G		No	ClinGen Ensembl
rs764181893 CA6847160	105	S>R		No	ClinGen ExAC TOPMed gnomAD
CA244778022 rs866133496	106	G>D		No	ClinGen Ensembl
rs1419688241 CA387050351	108	L>V		No	ClinGen TOPMed gnomAD
rs751828060 CA6847161	109	H>Q		No	ClinGen ExAC gnomAD
rs1429754355 CA387050363	109	H>R		No	ClinGen gnomAD
CA244778052 rs539288713	110	L>F		No	ClinGen 1000Genomes TOPMed gnomAD
rs539288713 CA387050368	110	L>V		No	ClinGen 1000Genomes TOPMed gnomAD
CA387050384 rs1475067577	111	I>T		No	ClinGen gnomAD
CA387050393 rs1565931372	112	H>P		No	ClinGen Ensembl
CA6847163 rs767875008	114	T>I		No	ClinGen ExAC gnomAD
CA387050423 rs1468032148	115	S>P		No	ClinGen gnomAD
rs377081405 CA6847164	118	T>A		No	ClinGen ESP ExAC gnomAD
CA387050477 rs1353227739	119	L>P		No	ClinGen gnomAD
rs75373025 CA6847165	121	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778374436 CA6847166	122	N>S		No	ClinGen ExAC gnomAD
CA387050618 rs1157036156	124	F>L		No	ClinGen gnomAD
COSM3792293 rs1420316614 CA387050652	126	Q>R	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
rs919548559 CA244779089	129	N>I		No	ClinGen TOPMed gnomAD
TCGA novel	129	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1404757658 CA387050710	130	D>G		No	ClinGen gnomAD
rs745774687 CA6847175	130	D>N		No	ClinGen ExAC TOPMed gnomAD
rs745774687 CA387050706	130	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA6847176 rs769888216	131	E>K		No	ClinGen ExAC gnomAD
rs374115933 CA6847178	133	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847177 rs775527571	133	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774369312 CA6847180	134	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6847179 rs375356431	134	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA387050789 rs1555221972	136	Y>*		No	ClinGen Ensembl
rs1216359269 CA387050780	136	Y>N		No	ClinGen gnomAD
rs866889590 CA244779137	142	E>*		No	ClinGen Ensembl
CA6847181 rs540651987	143	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs868427840 CA244779160	143	K>N		No	ClinGen Ensembl
CA387050896 rs1221608471	144	D>G		No	ClinGen TOPMed gnomAD
CA387050888 rs1489826976	144	D>N		No	ClinGen TOPMed gnomAD
rs1453112527 CA387050909	145	G>D		No	ClinGen gnomAD
rs558905859 CA6847183	147	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs947673621 CA244779201	148	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	148	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184211639 CA387051288	149	G>D		No	ClinGen gnomAD
rs1160490525 CA387050956	149	G>S		No	ClinGen gnomAD
CA6847202 rs781099032	152	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA387051322 rs781099032	152	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1381167604 CA387051353	155	L>V		No	ClinGen TOPMed
rs1167662017 CA387051367	156	L>R		No	ClinGen gnomAD
rs185354191 CA6847204	157	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6847205 rs779795415	158	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	162	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1048741995 CA244788592	163	C>G		No	ClinGen TOPMed
CA6847207 rs768614723	163	C>Y		No	ClinGen ExAC gnomAD
CA244788593 rs376431802	164	I>V		No	ClinGen ESP gnomAD
rs536299294 CA6847209	166	N>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772321810 CA6847211	168	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs772321810 CA6847210	168	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA6847212 rs760982854	169	L>V		No	ClinGen ExAC gnomAD
rs766782265 CA6847213	170	L>F		No	ClinGen ExAC TOPMed gnomAD
CA387051528 rs1190796241	171	K>E		No	ClinGen TOPMed
CA6847214 rs776939706	175	A>T		No	ClinGen ExAC
rs1472640510 CA387051881	175	A>V		No	ClinGen TOPMed
rs867893340 CA244790093	177	E>*		No	ClinGen Ensembl
CA387051903 rs1197663903	177	E>G		No	ClinGen gnomAD
CA387051937 rs1432290963	180	D>N		No	ClinGen gnomAD
CA387051938 rs1432290963	180	D>Y		No	ClinGen gnomAD
CA387051953 rs1218387406	181	F>I		No	ClinGen gnomAD
CA387051965 rs1318292216	181	F>L		No	ClinGen gnomAD
rs1284554601 CA387051959	181	F>Y		No	ClinGen gnomAD
CA244790103 rs370657369	182	S>I		No	ClinGen ESP TOPMed gnomAD
CA387051975 rs370657369	182	S>N		No	ClinGen ESP TOPMed gnomAD
rs1176321677 CA387051969	182	S>R		No	ClinGen gnomAD
rs761427660 CA244790104	182	S>R		No	ClinGen gnomAD
rs778828775 CA6847227	183	T>A		No	ClinGen ExAC TOPMed gnomAD
rs968385497 CA387051990	183	T>I		No	ClinGen TOPMed gnomAD
CA387051988 rs968385497	183	T>K		No	ClinGen TOPMed gnomAD
CA244790115 rs968385497	183	T>R		No	ClinGen TOPMed gnomAD
CA387051983 rs778828775	183	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1271628045 CA387051998	184	A>E		No	ClinGen gnomAD
rs1200826446 CA387051992	184	A>T		No	ClinGen gnomAD
CA387052022 rs1361033131	186	K>E		No	ClinGen gnomAD
CA387052097 rs1295529415	187	L>F		No	ClinGen gnomAD
CA387052100 rs1196061323	188	Q>*		No	ClinGen TOPMed
CA387052106 rs1239656405	189	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	194	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6847251 rs758410427	196	I>V		No	ClinGen ExAC gnomAD
CA387052188 rs1322715494	197	S>P		No	ClinGen gnomAD
rs61751320 CA6847252	198	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs901431253 CA244790766	198	T>I		No	ClinGen TOPMed
CA387052216 rs1177597087	199	E>G		No	ClinGen gnomAD
rs1456198403 CA387052210	199	E>K		No	ClinGen gnomAD
rs1161394850 CA387052261	201	Y>C		No	ClinGen gnomAD
CA387052273 rs1412919323	202	H>Y		No	ClinGen TOPMed gnomAD
CA6847254 rs747207034	203	T>S		No	ClinGen ExAC gnomAD
rs200109083 CA6847256	204	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs746191568 CA6847257	204	L>P		No	ClinGen ExAC gnomAD
rs770065963 CA387052304	205	G>C		No	ClinGen ExAC TOPMed gnomAD
rs770065963 CA6847258	205	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1231430958 CA387052334	207	L>F		No	ClinGen TOPMed
rs371618629 CA6847260	208	S>G		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA387052355 rs1380473894	209	L>I		No	ClinGen gnomAD
rs772898355 CA6847262	211	A>T		No	ClinGen ExAC gnomAD
rs760213772 CA6847263	212	G>R		No	ClinGen ExAC gnomAD
CA6847265 rs753456353	213	D>G		No	ClinGen ExAC gnomAD
CA387052424 rs1370326380	214	L>V		No	ClinGen TOPMed
CA6847266 rs759320142	215	A>T		No	ClinGen ExAC gnomAD
CA244790861 rs376295165	218	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847267 rs376295165	218	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA387052515 rs1593501090	219	P>S		No	ClinGen Ensembl
rs752631319 CA6847268	220	V>M		No	ClinGen ExAC
CA387052557 rs1473113505	221	I>M		No	ClinGen gnomAD
rs1183514803 CA387052579	223	G>W		No	ClinGen TOPMed gnomAD
rs749792196 CA6847279	224	G>R		No	ClinGen ExAC gnomAD
CA387053073 rs1177049362	225	T>A		No	ClinGen TOPMed gnomAD
CA6847280 rs769326636	225	T>N		No	ClinGen ExAC gnomAD
rs1011749393 CA244792191	226	G>S		No	ClinGen TOPMed
CA6847282 rs746479828	228	C>Y		No	ClinGen ExAC gnomAD
CA6847283 rs376367155	229	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA387053156 rs1296900756	231	S>L		No	ClinGen gnomAD
CA6847285 rs759182891	233	W>R		No	ClinGen ExAC gnomAD
rs765007039 CA6847286	235	P>S		No	ClinGen ExAC gnomAD
CA6847288 rs761841925	236	D>H		No	ClinGen ExAC TOPMed gnomAD
rs761841925 CA6847287	236	D>N		No	ClinGen ExAC TOPMed gnomAD
rs761841925 CA244792243	236	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1565940532 CA387053236	237	S>C		No	ClinGen Ensembl
CA387053249 rs1329698794	238	S>F		No	ClinGen TOPMed gnomAD
rs374749286 CA6847290	239	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387053267 rs1388499987	240	K>E		No	ClinGen TOPMed gnomAD
rs757294714 CA6847291	240	K>R		No	ClinGen ExAC gnomAD
CA6847292 rs767559140	241	G>A		No	ClinGen ExAC TOPMed gnomAD
rs756452873 CA6847294	244	V>A		No	ClinGen ExAC TOPMed gnomAD
rs780536530 CA6847295	245	K>E		No	ClinGen ExAC gnomAD
rs7968222 CA6847296 VAR_051082	245	K>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1449647355 CA387053315	245	K>R		No	ClinGen gnomAD
rs372499507 CA6847297	246	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1479060052 CA387053326	247	L>I		No	ClinGen gnomAD
rs779505717 CA6847298	248	I>T		No	ClinGen ExAC gnomAD
CA6847299 rs748610461	249	D>N		No	ClinGen ExAC TOPMed
rs1296373468 CA387053372	250	A>G		No	ClinGen TOPMed
TCGA novel	252	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773887656 CA6847317	255	G>D		No	ClinGen ExAC gnomAD
CA387053451 rs1209818822	256	A>G		No	ClinGen TOPMed gnomAD
rs369781146 CA6847319	258	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387053466 rs1446803863	258	K>R		No	ClinGen gnomAD
CA6847320 rs778371644	260	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs769304526 CA6847324	262	I>K		No	ClinGen ExAC
CA6847323 rs769304526	262	I>R		No	ClinGen ExAC
TCGA novel	263	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1265869805 CA387053502	264	N>D		No	ClinGen gnomAD
rs1336670374 CA387053507	264	N>K		No	ClinGen gnomAD
CA387053506 rs1231951575	264	N>S		No	ClinGen TOPMed
rs779611530 CA6847325	266	L>F		No	ClinGen ExAC TOPMed gnomAD
rs779611530 CA387053515	266	L>V		No	ClinGen ExAC TOPMed gnomAD
rs889132086 CA244792635	268	V>F		No	ClinGen TOPMed gnomAD
rs749006379 CA6847326	268	V>G		No	ClinGen ExAC TOPMed gnomAD
rs889132086 CA387053527	268	V>I		No	ClinGen TOPMed gnomAD
rs768424953 CA6847327	270	D>G		No	ClinGen ExAC gnomAD
rs1565941176 CA387053550	272	D>N		No	ClinGen Ensembl
rs748916551 CA6847346	273	N>Y		No	ClinGen ExAC gnomAD
CA6847348 rs778659714	274	V>M		No	ClinGen ExAC gnomAD
rs1284020568 CA387053611	276	S>N		No	ClinGen TOPMed
rs747849684 CA6847350	285	P>L		No	ClinGen ExAC gnomAD
rs1010322126 CA244793577	286	V>G		No	ClinGen Ensembl
CA6847352 rs200333356	287	W>*		No	ClinGen ExAC TOPMed gnomAD
rs560023303 CA6847351	287	W>R		No	ClinGen ExAC gnomAD
CA6847353 rs760763301	289	W>R		No	ClinGen ExAC gnomAD
CA387053784 rs1216492034	290	P>R		No	ClinGen gnomAD
CA6847355 rs776903535	291	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1000056624 CA244793636	293	H>Y		No	ClinGen Ensembl
rs765324143 CA6847357	294	V>I		No	ClinGen ExAC TOPMed gnomAD
CA387053831 rs1454299996	295	E>G		No	ClinGen gnomAD
CA6847358 rs752974228	295	E>Q		No	ClinGen ExAC gnomAD
rs958632192 CA244793657	296	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA6847360 rs764583850	298	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6847361 rs752046776	298	L>H		No	ClinGen ExAC gnomAD
CA387053863 rs764583850	298	L>V		No	ClinGen ExAC TOPMed gnomAD
CA387053881 rs1419571576	300	T>A		No	ClinGen TOPMed
rs757808952 CA387053884	300	T>N		No	ClinGen ExAC gnomAD
CA6847362 rs757808952	300	T>S		No	ClinGen ExAC gnomAD
rs1432564137 CA387053907	302	E>V		No	ClinGen TOPMed gnomAD
CA387053914 rs1292022927	303	A>T		No	ClinGen gnomAD
CA6847365 rs754539479	303	A>V		No	ClinGen ExAC gnomAD
CA387053932 rs1305782164	304	D>V		No	ClinGen gnomAD
CA6847368 rs191922047	305	S>A		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA387053944 rs1339405745	305	S>F		No	ClinGen gnomAD
CA6847370 rs561399189	306	P>T		No	ClinGen 1000Genomes ExAC
rs777771975 CA6847371	308	S>L		No	ClinGen ExAC gnomAD
rs1219776941	310	T>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA387053989 rs1200366382	310	T>A		No	ClinGen TOPMed
CA6847373 rs746924564	310	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1254288671 CA387054050	311	W>C		No	ClinGen TOPMed gnomAD
CA387054075 rs1465273348	313	G>E		No	ClinGen gnomAD
CA387054080 rs1244614892	314	I>V		No	ClinGen TOPMed
TCGA novel	316	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758123001 CA6847390	316	N>S		No	ClinGen ExAC TOPMed gnomAD
rs61751321 CA6847391	317	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746765192 CA6847392	320	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1380363212 CA387054187	324	A>T		No	ClinGen TOPMed gnomAD
CA244794081 rs983507804	324	A>V		No	ClinGen TOPMed gnomAD
rs116477881 CA6847393	326	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs116477881 CA6847394	326	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387054208 rs116477881	326	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs950254394 CA244794111	327	N>I		No	ClinGen TOPMed
rs769747766 CA6847397	329	K>N		No	ClinGen ExAC gnomAD
CA387054892 rs1487803789	331	K>E		No	ClinGen TOPMed gnomAD
rs1271702373 CA387054906	331	K>N		No	ClinGen TOPMed
CA387054929 rs1555224020	332	N>I		No	ClinGen Ensembl
rs1194180353 CA387054942	333	L>V		No	ClinGen gnomAD
CA387054966 rs1477097970	334	M>I		No	ClinGen gnomAD
CA6847411 rs368574278	335	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387055005 rs1343509135	337	S>L		No	ClinGen TOPMed
CA387055029 rs1395740357	340	T>A		No	ClinGen gnomAD
TCGA novel	340	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387055046 rs1555224041	341	M>R		No	ClinGen Ensembl
CA244795473 rs1007356503	341	M>V		No	ClinGen Ensembl
TCGA novel	343	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278101754 CA387055082	343	I>V		No	ClinGen TOPMed gnomAD
CA6847413 rs181801270	344	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA244795478 rs1006344631	347	L>*		No	ClinGen TOPMed gnomAD
CA387055134 rs1593515353	347	L>F		No	ClinGen Ensembl
rs1593515366 CA387055139	348	E>*		No	ClinGen Ensembl
CA387055136 rs1593515366	348	E>K		No	ClinGen Ensembl
rs1318601283 CA387055155	349	V>A		No	ClinGen gnomAD
CA387055149 rs753662975	349	V>I		No	ClinGen ExAC TOPMed gnomAD
rs753662975 CA6847414	349	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6847415 rs147259173	350	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1302134473 CA387055180	351	S>I		No	ClinGen gnomAD
TCGA novel	352	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6847416 rs200406704	353	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA387055210 rs1236416401	354	S>P		No	ClinGen TOPMed gnomAD
CA387055226 rs1283731999	355	L>P		No	ClinGen gnomAD
CA6847417 rs779887028	358	T>I		No	ClinGen ExAC TOPMed gnomAD
rs768736303 CA6847419	359	G>E		No	ClinGen ExAC gnomAD
CA6847418 rs140826574	359	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6847420 rs779041092	362	T>I		No	ClinGen ExAC gnomAD
CA6847431 rs761603840	363	D>N		No	ClinGen ExAC gnomAD
rs767388448 CA6847433	364	T>S		No	ClinGen ExAC gnomAD
rs372604813 CA244796647	365	I>L		No	ClinGen gnomAD
rs372604813 CA387055512	365	I>V		No	ClinGen gnomAD
rs369157449 CA6847435	366	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs375046231 CA244796653	366	Y>C		No	ClinGen ESP TOPMed gnomAD
CA387055521 rs375046231	366	Y>F		No	ClinGen ESP TOPMed gnomAD
rs779982973 CA6847436	368	L>S		No	ClinGen ExAC gnomAD
rs753723681 CA6847437	370	G>A		No	ClinGen ExAC TOPMed gnomAD
CA387055559 rs1217016681	372	C>F		No	ClinGen gnomAD
CA387055560 rs1169400295	372	C>W		No	ClinGen TOPMed
rs1250894440 CA387055563	373	K>E		No	ClinGen gnomAD
CA244796692 rs760633250	374	N>D		No	ClinGen gnomAD
CA387055576 rs1430525563	374	N>K		No	ClinGen TOPMed
CA387055571 rs760633250	374	N>Y		No	ClinGen gnomAD
rs1254416752 CA387055584	375	D>E		No	ClinGen TOPMed
CA387055612 rs1593519713	378	L>*		No	ClinGen Ensembl
CA387055637 rs1184422436	381	D>E		No	ClinGen gnomAD
rs1260549325 CA387055642	382	S>*		No	ClinGen gnomAD
rs542873141 CA244796775	385	V>L		No	ClinGen Ensembl
CA387055671 rs1555224375	387	V>L		No	ClinGen Ensembl
rs757640784 CA6847462	388	L>F		No	ClinGen ExAC gnomAD
CA6847463 rs373771355	388	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs757640784 CA387055676	388	L>V		No	ClinGen ExAC gnomAD
CA6847464 rs376756586	389	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA387055682 rs1377058661	389	R>T		No	ClinGen gnomAD
rs1417576210 CA387055686	390	C>R		No	ClinGen TOPMed gnomAD
CA6847465 rs770377591	391	L>F		No	ClinGen ExAC TOPMed gnomAD
CA6847466 rs776174066	391	L>P		No	ClinGen ExAC TOPMed gnomAD
CA244796816 rs549673609	392	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847467 rs549673609	392	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	393	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6847469 rs200040167	394	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1283018348 CA387055715	395	L>V		No	ClinGen gnomAD
CA6847490 rs777187101	401	S>N		No	ClinGen ExAC gnomAD
CA387055774 rs1408450834	402	R>Q		No	ClinGen gnomAD
rs770439701 CA6847492	402	R>W		No	ClinGen ExAC
rs759257455 CA6847494	404	L>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	406	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207530401 CA387055807	407	H>Y		No	ClinGen TOPMed
rs769585652 CA6847495	410	A>D		No	ClinGen ExAC gnomAD
CA387055872 rs1328074046	416	A>T		No	ClinGen gnomAD
CA6847497 rs775406246	416	A>V		No	ClinGen ExAC gnomAD
rs1299182365 CA387055877	417	I>V		No	ClinGen gnomAD
CA244797024 rs569164416	421	L>P		No	ClinGen gnomAD
CA6847499 rs764214072	422	D>G		No	ClinGen ExAC gnomAD
CA6847520 rs375661591	425	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1173811554 CA387056289	426	V>D		No	ClinGen TOPMed
CA387056314 rs1374877303	428	K>*		No	ClinGen TOPMed gnomAD
rs1246763982 CA387056336	429	V>G		No	ClinGen TOPMed
CA387056347 rs1190357240	430	K>R		No	ClinGen gnomAD
rs766736485 CA244801719	431	S>L		No	ClinGen Ensembl
rs766826642 CA6847523	434	I>T		No	ClinGen ExAC gnomAD
CA244801724 rs752360966	436	E>Q		No	ClinGen Ensembl
rs755398971 CA6847525	437	K>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	438	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244801761 rs992880450	439	A>E		No	ClinGen TOPMed
CA6847526 rs371290628	439	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA387056450 rs371290628	439	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847527 rs752704050	442	S>F		No	ClinGen ExAC gnomAD
CA387056488 rs1376461568	442	S>T		No	ClinGen gnomAD
CA244801788 rs752704050	442	S>Y		No	ClinGen ExAC gnomAD
rs1324365861 CA387056517	444	D>E		No	ClinGen gnomAD
rs756742187 CA6847528	444	D>G		No	ClinGen ExAC gnomAD
CA6847529 rs780724401	446	S>C		No	ClinGen ExAC gnomAD
CA387056539 rs1270327866	446	S>T		No	ClinGen gnomAD
CA244801806 COSM1359611 rs915581973	448	Q>*	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA6847532 rs78912868	449	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745501474 CA6847531	449	T>S		No	ClinGen ExAC gnomAD
CA6847535 rs748970408	450	E>*		No	ClinGen ExAC TOPMed gnomAD
CA6847534 rs748970408	450	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1565952795 CA387056607 COSM202651	451	W>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs774142753 CA6847537	454	L>F		No	ClinGen ExAC gnomAD
rs772247665 CA6847538	454	L>P		No	ClinGen ExAC gnomAD
rs774142753 CA6847536	454	L>V		No	ClinGen ExAC gnomAD
rs1452597981 CA387056658	455	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6847539 CA387056654 rs773473759	455	V>L		No	ClinGen ExAC TOPMed gnomAD
CA387056664 rs1396170347	456	D>G		No	ClinGen gnomAD
rs766666311 CA6847541	457	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1399758166 CA387056675	458	A>T		No	ClinGen TOPMed gnomAD
rs759759286 CA6847543	458	A>V		No	ClinGen ExAC gnomAD
CA6847544 rs765687281	459	K>E		No	ClinGen ExAC gnomAD
TCGA novel	459	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244801916 rs1028287113	462	L>P		No	ClinGen TOPMed
rs767959224 CA6847547	463	H>Q		No	ClinGen ExAC gnomAD
rs559913481 CA6847546	463	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847545 rs753135608	463	H>Y		No	ClinGen ExAC gnomAD
rs749897657 CA6847548	464	K>E		No	ClinGen ExAC TOPMed gnomAD
CA6847549 rs755628135	464	K>N		No	ClinGen ExAC TOPMed gnomAD
CA387056712 rs749897657	464	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs779516600 CA6847550	466	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	469	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244802133 rs569051769	474	Y>C		No	ClinGen Ensembl
rs367561262 CA6847570	475	C>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1438866812 CA387056873	476	L>P		No	ClinGen gnomAD
rs371401714 CA244802135	477	K>R		No	ClinGen ESP TOPMed
CA6847572 rs778452685	478	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA387056885 rs754707346	478	A>P		No	ClinGen ExAC TOPMed gnomAD
CA6847571 rs754707346	478	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6847573 rs376805094	480	W>*		No	ClinGen ESP ExAC gnomAD
rs1458952340 CA387056930	481	I>T		No	ClinGen gnomAD
rs758271309 CA6847574	481	I>V		No	ClinGen ExAC gnomAD
rs1307933557 CA387056948	483	Y>H		No	ClinGen gnomAD
rs777792491 CA6847575	484	E>V		No	ClinGen ExAC gnomAD
rs369856440 CA6847576	486	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA244802205 rs374194679	489	M>V		No	ClinGen ESP TOPMed gnomAD
rs770907680 CA6847578	491	N>D		No	ClinGen ExAC TOPMed gnomAD
CA387057048 rs770907680	491	N>H		No	ClinGen ExAC TOPMed gnomAD
CA244802212 rs941527026	493	A>V		No	ClinGen Ensembl
rs745960814 CA387057114	496	R>K		No	ClinGen ExAC TOPMed
rs745960814 CA6847581	496	R>T		No	ClinGen ExAC TOPMed
CA6847608 rs377551099	500	K>E		No	ClinGen ESP ExAC TOPMed
rs542034682 CA6847609	500	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	502	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387057586 rs1453702481	503	K>N		No	ClinGen gnomAD
rs561071987 CA6847610	503	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847611 rs774747519	504	T>I		No	ClinGen ExAC gnomAD
CA6847614 rs762105934	511	G>A		No	ClinGen ExAC TOPMed gnomAD
rs762105934 CA6847613	511	G>V		No	ClinGen ExAC TOPMed gnomAD
rs773891168 CA6847640	515	V>M		No	ClinGen ExAC gnomAD
CA6847641 rs761658001	517	R>K		No	ClinGen ExAC gnomAD
rs1248344259 CA387057701	519	H>R		No	ClinGen gnomAD
rs1165218113 CA387057704	520	A>T		No	ClinGen TOPMed
rs1176457819 CA387057721	522	L>S		No	ClinGen gnomAD
rs750344934 CA6847643	523	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1162973058 CA387057740	525	F>S		No	ClinGen gnomAD
rs756054860 CA6847646	526	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs766326903 CA6847648	527	G>A		No	ClinGen ExAC gnomAD
TCGA novel	528	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1442098777 CA387057777	531	P>A		No	ClinGen gnomAD
rs755054291 CA6847650	531	P>L		No	ClinGen ExAC gnomAD
CA6847651 rs779047252	533	K>N		No	ClinGen ExAC gnomAD
rs1593547799 CA387057809	535	S>I		No	ClinGen Ensembl
rs367877298 CA6847667	537	S>R		No	ClinGen ExAC gnomAD
rs1240438820 CA387058606	538	S>Y		No	ClinGen gnomAD
rs199501312 COSM75177 CA244813782	539	W>L	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA387058628 rs1277639997	540	I>T		No	ClinGen TOPMed
CA387058624 rs1593564233	540	I>V		No	ClinGen Ensembl
CA387058630 rs1217968446	541	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1475095347 CA387058639	542	F>L		No	ClinGen gnomAD
rs892014390 CA244813786	543	L>V		No	ClinGen TOPMed
CA244813816 rs1013211066	544	N>S		No	ClinGen TOPMed
CA387058661 rs1392612380	545	N>S		No	ClinGen TOPMed gnomAD
rs1453097789 CA387058670	546	E>G		No	ClinGen gnomAD
rs759598806 CA6847669	551	D>G		No	ClinGen ExAC TOPMed gnomAD
CA244813838 rs759598806	551	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1414691163 CA387058717	552	I>F		No	ClinGen gnomAD
CA387058725 rs1192084289	552	I>M		No	ClinGen gnomAD
rs548709340 CA244813864	553	F>V		No	ClinGen Ensembl
TCGA novel	554	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387058786 rs1335717127	557	K>E		No	ClinGen TOPMed gnomAD
CA6847673 rs752929321	557	K>N		No	ClinGen ExAC gnomAD
rs530543264 CA6847671	557	K>T		No	ClinGen 1000Genomes ExAC
CA387058867 rs1433663750	560	N>T		No	ClinGen gnomAD
CA387058907 rs1320605046	562	V>F		No	ClinGen TOPMed gnomAD
CA6847674 rs778075421	563	C>Y		No	ClinGen ExAC gnomAD
CA6847675 rs751808157	565	Q>*		No	ClinGen ExAC gnomAD
CA387058966 rs1593564604	565	Q>R		No	ClinGen Ensembl
CA387058987 rs1413832011	566	Y>C		No	ClinGen TOPMed
rs1274033130 CA387058991	567	L>I		No	ClinGen gnomAD
CA387059007 rs1425789085	568	W>*		No	ClinGen TOPMed
TCGA novel	569	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1212742 CA6847676 rs368001390	570	R>*	NS large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
COSM202653 rs781762358 CA6847677	570	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs746448268 CA6847678	571	H>R		No	ClinGen ExAC TOPMed gnomAD
CA6847680 rs778336279	572	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs199781100 CA6847679	572	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1162091500 CA387059728	573	A>G		No	ClinGen gnomAD
rs777275248 CA6847702	575	F>L		No	ClinGen ExAC gnomAD
rs746731271 CA6847703	577	S>G		No	ClinGen ExAC gnomAD
rs1326687921 CA387059760	577	S>R		No	ClinGen gnomAD
CA6847704 rs770678455	579	F>L		No	ClinGen ExAC gnomAD
CA244814953 rs373899483	580	D>E		No	ClinGen Ensembl
CA6847705 rs776454941	581	V>M		No	ClinGen ExAC gnomAD
CA387059799 rs1290399273	583	M>T		No	ClinGen gnomAD
rs1353677041 CA387059820	586	S>N		No	ClinGen gnomAD
CA387059830 rs1244208704	587	L>F		No	ClinGen gnomAD
CA387059834 rs1266088544	588	L>F		No	ClinGen gnomAD
CA6847706 rs759345713	588	L>P		No	ClinGen ExAC gnomAD
rs868441714 CA244814973	589	N>S		No	ClinGen Ensembl
rs1444537448 CA387059851	591	M>V		No	ClinGen TOPMed
rs1274386656 CA387059864	592	S>F		No	ClinGen gnomAD
CA387059892 rs1253576104	597	L>S		No	ClinGen gnomAD
TCGA novel	599	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs192844811 CA6847711	606	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA244815057 rs983223300	612	V>L		No	ClinGen Ensembl
CA6847712 rs762176017	615	T>I		No	ClinGen ExAC TOPMed gnomAD
rs767875424 CA6847713	616	V>G		No	ClinGen ExAC gnomAD
TCGA novel	622	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1256261426 CA387060092	624	A>V		No	ClinGen gnomAD
rs1186629682 CA387060104	626	W>*		No	ClinGen gnomAD
rs887294313 CA244815793	628	E>K		No	ClinGen TOPMed gnomAD
rs773917767 CA244815794	631	A>T		No	ClinGen TOPMed gnomAD
CA387060190 rs1372404574	634	L>F		No	ClinGen TOPMed
rs756850308 CA6847721	634	L>H		No	ClinGen ExAC gnomAD
CA244815801 rs1017151061	637	T>S		No	ClinGen gnomAD
rs1465740816 CA387060248	639	K>Q		No	ClinGen gnomAD
CA387060292 rs1176476980	640	A>T		No	ClinGen gnomAD
rs1379639385 CA387060305	641	N>D		No	ClinGen gnomAD
rs1379639385 CA387060303	641	N>H		No	ClinGen gnomAD
CA244815894 rs868050398	643	P>S		No	ClinGen Ensembl
CA387060350 rs1389381122	644	E>A		No	ClinGen gnomAD
CA387060375 rs1266791706	646	G>R		No	ClinGen TOPMed
rs773583890 CA6847734	648	Q>*		No	ClinGen ExAC gnomAD
rs773583890 CA6847735	648	Q>E		No	ClinGen ExAC gnomAD
CA6847736 rs766831404	652	I>T		No	ClinGen ExAC gnomAD
rs1387749462 CA387060473	653	F>L		No	ClinGen gnomAD
TCGA novel	654	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1313651215 CA387060499	656	A>T		No	ClinGen gnomAD
CA387060526 rs1226188872	658	K>E		No	ClinGen gnomAD
CA6847739 COSM1212741 rs755557444	659	T>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
COSM936253 rs765751440 CA6847740	661	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6847743 rs756760642	662	L>F		No	ClinGen ExAC TOPMed gnomAD
CA387060581 rs1488104365	662	L>W		No	ClinGen TOPMed gnomAD
CA6847744 rs745602896	664	L>F		No	ClinGen ExAC TOPMed gnomAD
rs779952017 CA6847746	665	A>G		No	ClinGen ExAC gnomAD
rs755837728 CA6847745	665	A>T		No	ClinGen ExAC gnomAD
rs1282030489 CA387060651	668	W>*		No	ClinGen TOPMed
CA6847749 rs774436499	670	W>*		No	ClinGen ExAC gnomAD
rs1458857800 CA387060677	670	W>*		No	ClinGen gnomAD
CA387060718 rs1405059681	673	L>F		No	ClinGen TOPMed
rs1291560513 CA387060858	676	Y>H		No	ClinGen TOPMed
rs754835336 CA6847771	681	E>K		No	ClinGen ExAC gnomAD
rs374600519 CA244817679	682	V>E		No	ClinGen Ensembl
rs778983133 CA6847772	682	V>I		No	ClinGen ExAC gnomAD
TCGA novel	686	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387060991 rs1483594859	689	V>I		No	ClinGen gnomAD
rs1565971414 CA387061003	690	N>D		No	ClinGen Ensembl
CA6847773 rs748161276	692	L>S		No	ClinGen ExAC gnomAD
CA387061043 rs1388909186	693	R>*		No	ClinGen gnomAD
rs772245787 CA387061047	693	R>L		No	ClinGen ExAC TOPMed gnomAD
rs772245787 CA6847774	693	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs376075644 CA6847775	694	E>*		No	ClinGen ESP ExAC gnomAD
rs376075644 CA387061051	694	E>Q		No	ClinGen ESP ExAC gnomAD
rs763502647 CA6847777	697	T>M		No	ClinGen ExAC TOPMed gnomAD
rs776720381 CA6847778	698	L>*		No	ClinGen ExAC gnomAD
rs369843247 CA6847779	699	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs770212695 CA6847781	701	K>*		No	ClinGen ExAC TOPMed gnomAD
CA387061137 rs770212695	701	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs775948010 CA6847782	701	K>R		No	ClinGen ExAC gnomAD
CA6847783 rs763503709	703	N>D		No	ClinGen ExAC TOPMed gnomAD
CA6847784 rs763503709	703	N>H		No	ClinGen ExAC TOPMed gnomAD
rs760109261 CA6847786	703	N>K		No	ClinGen ExAC gnomAD
rs749909411 CA6847785	703	N>S		No	ClinGen ExAC TOPMed gnomAD
rs753494900 CA6847788	707	A>V		No	ClinGen ExAC gnomAD
rs1555228942 CA387061223	708	L>F		No	ClinGen Ensembl
rs778891147 CA6847791	709	S>F		No	ClinGen ExAC gnomAD
rs758361544 CA6847793	713	K>N		No	ClinGen ExAC TOPMed gnomAD
rs759309380 CA6847807	716	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1164965207 CA387054630	719	I>T		No	ClinGen TOPMed gnomAD
CA387054644 rs191772462	720	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847808 rs191772462	720	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1188644 CA6847809 rs534237685	721	F>Y	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA6847810 rs201331566	722	R>*		No	ClinGen ExAC TOPMed gnomAD
rs201331566 CA244752373	722	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1322653956 CA387054667 COSM936255	722	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM307473 rs751507258 CA6847812	723	M>I	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs899016563 CA387054716	725	D>G		No	ClinGen Ensembl
rs899016563 CA244752378	725	D>V		No	ClinGen Ensembl
CA6847813 rs374239725	726	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847814 rs759849356	727	V>M		No	ClinGen ExAC TOPMed gnomAD
rs377204060 CA244752380	729	A>S		No	ClinGen ESP TOPMed
rs377204060 CA387054752	729	A>T		No	ClinGen ESP TOPMed
rs1396604089 CA387054756	729	A>V		No	ClinGen TOPMed
rs1593578889 CA387054761	730	P>R		No	ClinGen Ensembl
rs745972828 CA6847815	730	P>S		No	ClinGen ExAC gnomAD
CA387054791 rs1291057638	732	L>R		No	ClinGen gnomAD
rs1249224945 CA387054875	738	E>A		No	ClinGen TOPMed gnomAD
VAR_051083 rs17883249 CA6847817 COSM3688003 CA387054888	738	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD UniProt dbSNP
CA6847816 rs533682868	738	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	739	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387054939 rs1182349957	740	F>L		No	ClinGen gnomAD
rs374356823 CA6847818	741	I>V		No	ClinGen ESP ExAC gnomAD
CA6847819 rs768960218	743	V>I		No	ClinGen ExAC gnomAD
rs1162534401 CA387054997	745	M>V		No	ClinGen gnomAD
rs367576553 CA244752383	746	R>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847820 rs367576553	746	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6847821 rs61751322	748	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770450706 CA6847822	751	Q>E		No	ClinGen ExAC gnomAD
rs776231796 CA6847823	751	Q>R		No	ClinGen ExAC gnomAD
CA387055111 rs1410662606	752	E>D		No	ClinGen gnomAD
CA6847826 rs775291338	757	L>F		No	ClinGen ExAC gnomAD
rs1362186537 CA387055227	761	E>K		No	ClinGen TOPMed gnomAD
rs935408895 CA244752574	762	D>Y		No	ClinGen TOPMed gnomAD
rs1555229328 CA387055319	765	N>S		No	ClinGen Ensembl
CA6847848 rs773980969	767	C>R		No	ClinGen ExAC gnomAD
CA387055349 COSM458240 rs1172234996	769	S>*	cervix [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs767384290 CA6847851	779	W>*		No	ClinGen ExAC gnomAD
CA6847852 rs750419356	781	A>P		No	ClinGen ExAC gnomAD
CA387055441 rs1320421692	783	A>P		No	ClinGen gnomAD
rs1593581655 CA387055452	784	M>I		No	ClinGen Ensembl
rs1384323861 CA387055460	785	A>V		No	ClinGen gnomAD
rs760741394 CA6847853	786	V>L		No	ClinGen ExAC gnomAD
CA387055470 rs1329062508	787	I>T		No	ClinGen TOPMed gnomAD
rs1371962771 CA387055473	788	A>T		No	ClinGen TOPMed
rs766486969 CA6847854	788	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	792	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201148456 CA6847856	793	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1027639757 CA387055961	794	D>E		No	ClinGen TOPMed
rs752933234 CA6847858	794	D>G		No	ClinGen ExAC gnomAD
CA387055956 rs1267474684	794	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753818045 CA6847875	796	I>T		No	ClinGen ExAC gnomAD
CA6847874 rs766322919	796	I>V		No	ClinGen ExAC gnomAD
CA6847876 rs199954329	798	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA244752831 rs867052971	799	A>V		No	ClinGen Ensembl
rs1163233829 CA387056006	800	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1172572678 CA387056014	801	L>F		No	ClinGen TOPMed
rs753021299 CA387056021	802	K>R		No	ClinGen ExAC TOPMed
rs753021299 CA6847879	802	K>T		No	ClinGen ExAC TOPMed
rs375872082 CA6847880	803	I>T		No	ClinGen ESP ExAC gnomAD
CA387056038 rs1367117629	804	M>I		No	ClinGen TOPMed gnomAD
rs752088372 CA6847882	804	M>R		No	ClinGen ExAC gnomAD
CA387056031 rs1426875939	804	M>V		No	ClinGen TOPMed
rs757801099 CA6847883	806	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1306882053 CA387056052	807	A>T		No	ClinGen gnomAD
rs1373359866 CA387056064	809	V>I		No	ClinGen gnomAD
rs151068294 CA6847885	810	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1242039365 CA387056085	812	S>G		No	ClinGen TOPMed
rs754578533 CA6847886	812	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1242039365 CA387056084	812	S>R		No	ClinGen TOPMed
rs1204630767 CA387056098	814	A>P		No	ClinGen TOPMed gnomAD
CA387056097 rs1204630767	814	A>T		No	ClinGen TOPMed gnomAD
rs747877355 CA6847888	815	V>M		No	ClinGen ExAC TOPMed gnomAD
CA387056111 rs1279354795	816	E>G		No	ClinGen TOPMed gnomAD
rs1414770400 CA387056108	816	E>K		No	ClinGen gnomAD
rs1180163965 CA387056129	819	V>M		No	ClinGen gnomAD
CA387056145 rs1342812312	821	Q>*		No	ClinGen TOPMed gnomAD
rs372506657 CA387056161	823	L>P		No	ClinGen ESP ExAC gnomAD
rs372506657 CA6847890	823	L>Q		No	ClinGen ESP ExAC gnomAD
rs376521489 CA6847891	824	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1593584867 CA387056181	826	D>Y		No	ClinGen Ensembl
rs746745688 CA6847910	831	K>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	831	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	831	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	832	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1164918387 CA387056248	834	Q>K		No	ClinGen TOPMed
CA387056296 rs1342873730	837	Y>*		No	ClinGen TOPMed gnomAD
rs1593585440 CA387056294	837	Y>F		No	ClinGen Ensembl
CA244752875 rs1007792770	838	K>N		No	ClinGen TOPMed gnomAD
CA387056355 rs1429831632	841	E>D		No	ClinGen gnomAD
CA6847911 rs200445300	842	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1565975016 CA387056393	843	K>N		No	ClinGen Ensembl
rs776428677 CA6847913	843	K>Q		No	ClinGen ExAC gnomAD
rs1278025893 CA387056405	844	K>R		No	ClinGen gnomAD
CA387056417 rs1324317872	845	L>F		No	ClinGen gnomAD
rs868854352 CA244752878	846	L>I		No	ClinGen Ensembl
rs745858002 CA6847914	847	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA387056440 rs769739544	847	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769739544 COSM3811325 CA6847915	847	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs377553046 CA6847916	848	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA387056462 rs1273257174	849	Y>C		No	ClinGen TOPMed gnomAD
CA6847918 rs764354490	851	I>M		No	ClinGen ExAC TOPMed gnomAD
rs763131992 CA6847917	851	I>V		No	ClinGen ExAC TOPMed gnomAD
CA387056499 rs1593585670	852	R>K		No	ClinGen Ensembl
TCGA novel	853	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774771775 CA6847919	854	V>I		No	ClinGen ExAC gnomAD
rs1177942781 CA387056536	855	N>Y		No	ClinGen gnomAD
rs762268029 CA6847920	856	L>F		No	ClinGen ExAC gnomAD
rs530518298 CA6847921	858	N>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1390645890 CA387056586	858	N>K		No	ClinGen TOPMed
rs767486222 CA6847922	859	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1555229794 CA387056600	859	K>N		No	ClinGen Ensembl
CA244752886 rs959739552	861	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA244752888 rs202112178	862	M>I		No	ClinGen Ensembl
rs1439789532 CA387056770	864	V>M		No	ClinGen TOPMed gnomAD
rs766849327 CA387056786	865	V>I		No	ClinGen ExAC gnomAD
CA6847945 rs766849327	865	V>L		No	ClinGen ExAC gnomAD
rs202085825 CA6847946	866	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs762442542 CA6847947	867	Y>C		No	ClinGen ExAC gnomAD
CA6847948 rs530141366	868	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847949 rs751189646	870	K>*		No	ClinGen ExAC gnomAD
rs756883663 CA6847951	870	K>N		No	ClinGen ExAC TOPMed gnomAD
CA387056883 rs1310759654	871	Q>H		No	ClinGen TOPMed
rs964844484 CA387056906	873	V>F		No	ClinGen TOPMed gnomAD
rs964844484 CA244753175	873	V>I		No	ClinGen TOPMed gnomAD
CA6847953 rs183574130	875	S>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847956 rs749282000	878	E>A		No	ClinGen ExAC gnomAD
rs749282000 CA6847957	878	E>G		No	ClinGen ExAC gnomAD
CA6847958 rs779089672	879	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1288762934 CA387057006	881	L>V		No	ClinGen gnomAD
rs534177397 CA6847961	883	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6847962 rs773316799	885	Q>*		No	ClinGen ExAC gnomAD
rs928965525 CA244753178	885	Q>H		No	ClinGen TOPMed gnomAD
rs761083498 CA6847963	886	A>V		No	ClinGen ExAC TOPMed gnomAD
CA387057110 rs1370437997	888	M>T		No	ClinGen gnomAD
CA6847965 rs777090601	888	M>V		No	ClinGen ExAC TOPMed gnomAD
CA387057138 rs917175141	890	S>F		No	ClinGen TOPMed gnomAD
TCGA novel	890	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244753183 rs917175141	890	S>Y		No	ClinGen TOPMed gnomAD
rs997827844 CA244753185	891	D>N		No	ClinGen TOPMed
rs949888288 CA244753187	891	D>V		No	ClinGen TOPMed
CA6847966 rs559023746	892	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1226602792 CA387057158	893	E>D		No	ClinGen gnomAD
CA244753191 rs751306591	894	I>T		No	ClinGen Ensembl
rs113598460 CA244753195	895	Y>C		No	ClinGen Ensembl
CA244753197 rs113598460	895	Y>F		No	ClinGen Ensembl
rs1338282322 CA387057191	898	R>S		No	ClinGen gnomAD
CA387057199 rs1287728119	900	I>L		No	ClinGen TOPMed
rs1195879620 CA387057219	903	I>L		No	ClinGen gnomAD
CA244753203 rs1044649586	904	D>E		No	ClinGen TOPMed
rs761243612 CA6847969	905	R>G		No	ClinGen ExAC gnomAD
rs905928288 CA244753206	906	E>Q		No	ClinGen TOPMed
CA387057268 rs776931208	908	G>D		No	ClinGen ExAC gnomAD
rs201253327 CA6847984	908	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6847985 rs776931208	908	G>V		No	ClinGen ExAC gnomAD
CA387057278 rs1203164932	910	D>N		No	ClinGen gnomAD
rs1171300875 CA387057289	911	C>Y		No	ClinGen TOPMed
TCGA novel	912	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1260768321 CA387057298	912	L>R		No	ClinGen gnomAD
rs770218433 CA6847987	916	K>T		No	ClinGen ExAC TOPMed gnomAD
CA6847988 rs201402164	919	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387057343 rs1480165906	920	P>S		No	ClinGen TOPMed gnomAD
CA387057345 rs1480165906	920	P>T		No	ClinGen TOPMed gnomAD
rs1262732018 CA387057365	923	A>S		No	ClinGen TOPMed
rs772902325 CA6847991	926	T>A		No	ClinGen ExAC gnomAD
rs1288716467 CA387057404	929	R>G		No	ClinGen gnomAD
rs1217683300 CA387057418	931	I>V		No	ClinGen TOPMed
rs927234865 CA244753381	932	I>M		No	ClinGen TOPMed gnomAD
CA6847993 rs527750148	932	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA244753384 rs982830899	933	W>C		No	ClinGen Ensembl
rs371376144 CA6847994	935	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs754831260 COSM1212737 CA6847996	935	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA6847997 rs765249849	936	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1283294877 CA387057450	937	A>T		No	ClinGen gnomAD
rs921076390 CA244753397	939	Q>*		No	ClinGen Ensembl
TCGA novel	939	Q>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848000 rs777763189	941	E>K		No	ClinGen ExAC gnomAD
CA6848001 rs552563596	942	P>A		No	ClinGen 1000Genomes ExAC
rs1206628053 CA387057493	943	D>G		No	ClinGen gnomAD
CA6848002 rs757428476	943	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1432506693 CA387057499	944	H>D		No	ClinGen TOPMed
rs781396154 CA6848003	945	S>P		No	ClinGen ExAC gnomAD
rs1357097962 CA387057528	947	E>Q		No	ClinGen TOPMed
CA387057822 rs1394188711	948	G>C		No	ClinGen gnomAD
CA244754234 rs972400567	948	G>D		No	ClinGen TOPMed gnomAD
CA387057820 rs1394188711	948	G>S		No	ClinGen gnomAD
rs972400567 CA387057823	948	G>V		No	ClinGen TOPMed gnomAD
rs1191251594 CA387057826	949	K>E		No	ClinGen TOPMed
rs780232822 CA6848025	951	W>*		No	ClinGen ExAC gnomAD
CA6848026 rs749697542	952	R>I		No	ClinGen ExAC gnomAD
CA6848028 rs768980416	955	V>I		No	ClinGen ExAC gnomAD
CA387057875 rs1214228825	956	A>S		No	ClinGen TOPMed
rs199590387 CA6848029	956	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6848032 rs539670629	960	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769507476 CA6848034	962	I>N		No	ClinGen ExAC gnomAD
TCGA novel	962	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759307322 CA6848033	962	I>V		No	ClinGen ExAC TOPMed gnomAD
rs775106528 CA6848035	966	L>V		No	ClinGen ExAC gnomAD
rs762808770 CA6848036	967	C>S		No	ClinGen ExAC TOPMed gnomAD
CA387057962 rs1369869155	969	I>M		No	ClinGen TOPMed
rs1565980045 CA387057960	969	I>T		No	ClinGen Ensembl
CA387057957 rs1251960122	969	I>V		No	ClinGen gnomAD
TCGA novel	970	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763878615 CA387057966	970	Q>P		No	ClinGen ExAC gnomAD
rs763878615 CA6848037	970	Q>R		No	ClinGen ExAC gnomAD
rs200477285 CA6848038	971	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA387057972 rs1452894348	971	K>T		No	ClinGen TOPMed
rs748702894 CA6848048	972	D>G		No	ClinGen ExAC gnomAD
rs1229730562 CA387058016	976	K>*		No	ClinGen TOPMed
rs201575472 CA387058040	979	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848049 rs201575472	979	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA387058063 rs1185542643	982	E>*		No	ClinGen gnomAD
CA387058075 CA387058076 rs1173558821	983	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA387058073 rs370526642	983	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1419743292 CA387058070	983	M>L		No	ClinGen gnomAD
CA6848051 rs370526642	983	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848050 rs370526642	983	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	987	F>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244754459 rs866733759	989	E>*		No	ClinGen Ensembl
rs1428523014 CA387058137	989	E>D		No	ClinGen gnomAD
rs769264395 CA6848052	990	V>G		No	ClinGen ExAC gnomAD
CA387058155 rs1335998327	991	A>V		No	ClinGen gnomAD
TCGA novel	995	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765680842 CA6848068	996	N>D		No	ClinGen ExAC gnomAD
CA387058760 rs1159487753	997	F>L		No	ClinGen gnomAD
TCGA novel	998	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848069 rs753130990	1000	F>C		No	ClinGen ExAC gnomAD
CA6848070 rs758932288	1001	L>P		No	ClinGen ExAC gnomAD
rs1302687696 CA387058890	1004	E>A		No	ClinGen gnomAD
CA244755118 rs927131220	1006	Y>D		No	ClinGen Ensembl
CA244755120 rs772077758	1007	S>N		No	ClinGen TOPMed gnomAD
rs568900680 CA6848071	1008	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387059030 rs1381415407	1009	S>T		No	ClinGen gnomAD
rs1278321142 CA387059043	1010	S>T		No	ClinGen gnomAD
rs201981485 CA6848073	1012	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs779543176 CA6848074	1014	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	1015	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848075 rs536586893	1016	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA6848077 rs370881274	1016	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6848076 rs370881274	1016	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387059210 rs1267603546	1020	I>V		No	ClinGen gnomAD
rs1396301441 CA387059225	1021	K>E		No	ClinGen TOPMed
CA6848078 rs747945385	1022	A>T		No	ClinGen ExAC gnomAD
CA6848079 rs771941717	1022	A>V		No	ClinGen ExAC gnomAD
TCGA novel	1024	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848081 rs760669670	1024	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1177631943 CA387059306	1026	A>V		No	ClinGen gnomAD
rs374190938 CA6848082	1027	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA244755157 rs917214679	1028	A>T		No	ClinGen gnomAD
CA6848084 rs759752691	1028	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1469058050 CA387059348	1033	G>R		No	ClinGen TOPMed
rs758845238 CA6848088	1035	T>I		No	ClinGen ExAC TOPMed gnomAD
rs764683680 CA6848089	1036	P>A		No	ClinGen ExAC gnomAD
rs201046154 CA6848090	1037	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs190859355 CA6848092	1039	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775609964 CA244755170	1041	A>S		No	ClinGen Ensembl
rs748782051 CA6848093	1043	V>L		No	ClinGen ExAC TOPMed gnomAD
rs754594527 CA6848094	1044	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1225329039 CA387059434	1046	P>L		No	ClinGen TOPMed
rs1437220161 CA387059436	1047	S>G		No	ClinGen gnomAD
CA387059445 rs1186462644	1048	M>L		No	ClinGen gnomAD
rs1302400186 CA387059476	1052	L>Q		No	ClinGen TOPMed
rs1565983599 CA387059487	1054	R>G		No	ClinGen Ensembl
rs1442568658 CA387059495	1055	Q>*		No	ClinGen gnomAD
TCGA novel rs1182691141 CA387059500	1055	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA387059502 rs374767073	1056	A>S		No	ClinGen ESP TOPMed gnomAD
CA244755184 rs374767073	1056	A>T		No	ClinGen ESP TOPMed gnomAD
rs1473895864 CA387059506	1056	A>V		No	ClinGen gnomAD
CA387059516 rs1160739010	1058	A>V		No	ClinGen TOPMed
CA387059529 rs1395834717	1060	Q>H		No	ClinGen TOPMed gnomAD
CA6848097 rs148237388	1061	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848098 rs777652354	1063	K>T		No	ClinGen ExAC gnomAD
CA244755192 rs944046804	1064	Q>K		No	ClinGen Ensembl
rs61750348 CA6848100	1065	E>K		No	ClinGen ExAC TOPMed gnomAD
CA387059572 rs1565983769	1067	E>Q		No	ClinGen Ensembl
rs759537334 CA6848102	1068	A>V		No	ClinGen ExAC gnomAD
CA387059591 rs1246509736	1069	E>D		No	ClinGen TOPMed gnomAD
CA387059600 rs1267943240	1071	T>I		No	ClinGen gnomAD
CA6848104 rs371793371	1080	I>V		No	ClinGen ESP ExAC gnomAD
CA6848106 rs201517227	1081	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA387059676 rs1256581043	1082	T>K		No	ClinGen gnomAD
rs1372679140 CA387059681	1083	A>E		No	ClinGen gnomAD
CA6848108 rs141767241	1083	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1475794952 CA387059684	1084	L>M		No	ClinGen gnomAD
rs767915646 CA6848109	1084	L>Q		No	ClinGen ExAC gnomAD
TCGA novel	1086	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1234974852 CA387059699	1086	K>T		No	ClinGen TOPMed
rs753334234 CA6848110	1087	C>F		No	ClinGen ExAC gnomAD
rs754544017 CA6848111	1087	C>W		No	ClinGen ExAC gnomAD
CA6848112 rs200596757	1088	S>G		No	ClinGen ExAC gnomAD
CA6848133 rs777291592	1089	D>N		No	ClinGen ExAC TOPMed gnomAD
CA387060162 rs1565985167	1090	L>S		No	ClinGen Ensembl
CA6848135 rs751308711	1091	F>L		No	ClinGen ExAC TOPMed gnomAD
CA244755529 rs1049571119	1091	F>L		No	ClinGen Ensembl
CA244755530 rs868068084	1092	K>*		No	ClinGen Ensembl
rs757056297 CA6848136	1092	K>R		No	ClinGen ExAC gnomAD
CA6848137 rs781184317	1095	C>F		No	ClinGen ExAC gnomAD
CA387060258 rs1302892806	1096	N>S		No	ClinGen gnomAD
CA387060273 rs1565985244	1097	A>G		No	ClinGen Ensembl
CA6848138 rs745840180	1097	A>T		No	ClinGen ExAC gnomAD
CA6848139 rs756144044	1100	G>A		No	ClinGen ExAC TOPMed gnomAD
CA387060337 rs1419972138	1102	L>W		No	ClinGen gnomAD
rs749384779 CA387060390	1106	T>I		No	ClinGen ExAC TOPMed gnomAD
CA6848141 rs749384779	1106	T>K		No	ClinGen ExAC TOPMed gnomAD
rs1423466477 CA387060395	1107	C>R		No	ClinGen gnomAD
CA244755549 rs377539396	1111	C>F		No	ClinGen ESP
CA387060455 rs1177822300	1111	C>R		No	ClinGen TOPMed
CA244755548 rs377539396	1111	C>S		No	ClinGen ESP
rs768942364 CA387060479	1112	Q>H		No	ClinGen ExAC gnomAD
CA6848143 rs774497403	1113	M>K		No	ClinGen ExAC TOPMed gnomAD
rs927260136 CA244755554	1113	M>L		No	ClinGen TOPMed gnomAD
CA244755557 rs774497403	1113	M>T		No	ClinGen ExAC TOPMed gnomAD
rs927260136 CA387060486	1113	M>V		No	ClinGen TOPMed gnomAD
CA387060532 rs772367216	1116	D>H		No	ClinGen ExAC gnomAD
CA6848145 rs772367216	1116	D>Y		No	ClinGen ExAC gnomAD
rs761117849 CA6848147	1119	P>A		No	ClinGen ExAC gnomAD
CA6848148 rs370952397	1119	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1479973332 CA387060586	1120	V>M		No	ClinGen gnomAD
CA6848150 rs762460965	1121	T>I		No	ClinGen ExAC
rs1593609727 CA387060643	1124	V>G		No	ClinGen Ensembl
CA387060633 rs1446570643	1124	V>M		No	ClinGen TOPMed
rs751235512 CA6848152	1125	G>E		No	ClinGen ExAC gnomAD
CA6848153 rs762124576	1126	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1422871506 CA387060683	1127	N>K		No	ClinGen gnomAD
CA6848155 rs750274991	1127	N>S		No	ClinGen ExAC gnomAD
CA387060700 rs1164928488	1129	P>A		No	ClinGen gnomAD
rs756049169 CA6848156	1131	M>V		No	ClinGen ExAC gnomAD
CA6848157 rs61751323	1132	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA387060736 rs1219423656	1132	I>V		No	ClinGen gnomAD
CA6848159 rs371428062	1134	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1330621580 CA387060751	1134	D>H		No	ClinGen gnomAD
CA6848158 rs371428062	1134	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs779167750 CA6848160	1137	S>N		No	ClinGen ExAC gnomAD
rs779167750 CA387060769	1137	S>T		No	ClinGen ExAC gnomAD
rs772365714 CA6848163	1143	C>*		No	ClinGen ExAC
rs748371320 CA6848162	1143	C>Y		No	ClinGen ExAC
TCGA novel	1148	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1444088158	1148	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848181 rs752849627	1150	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1278915597 CA387061040	1155	C>R		No	ClinGen TOPMed gnomAD
rs530220395 CA6848182	1158	T>I		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1158	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754996062 CA6848183	1161	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6848184 rs747358470	1162	V>G		No	ClinGen ExAC gnomAD
rs1038774403 CA244755769	1162	V>I		No	ClinGen TOPMed gnomAD
CA6848185 rs541948519	1164	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1238851292 CA387061254	1171	D>G		No	ClinGen TOPMed gnomAD
CA6848186 rs374132869 COSM3772296	1171	D>Y	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6848187 rs746410866	1173	C>R		No	ClinGen ExAC gnomAD
rs1192381228 CA387061273	1174	G>R		No	ClinGen gnomAD
CA387061324 rs1376668602	1179	A>G		No	ClinGen gnomAD
rs1565986989 CA387061326	1180	S>A		No	ClinGen Ensembl
rs771751080 CA6848209	1182	G>E		No	ClinGen ExAC gnomAD
CA387061345 rs1355321899	1183	T>P		No	ClinGen gnomAD
CA387061355 rs772980531	1184	H>P		No	ClinGen ExAC gnomAD
rs772980531 CA6848210	1184	H>R		No	ClinGen ExAC gnomAD
rs1406664710 CA387061353	1184	H>Y		No	ClinGen TOPMed
CA244756008 rs916537311	1185	K>E		No	ClinGen gnomAD
CA387061367 rs1338405324	1186	D>V		No	ClinGen TOPMed
CA6848211 rs760358342	1186	D>Y		No	ClinGen ExAC gnomAD
rs371931759 CA387061372	1187	P>A		No	ClinGen ExAC TOPMed gnomAD
rs371931759 CA6848212	1187	P>T		No	ClinGen ExAC TOPMed gnomAD
rs776217427 CA6848213	1188	Y>H		No	ClinGen ExAC gnomAD
CA6848214 rs533594471	1189	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1386875860 CA387061394	1190	E>A		No	ClinGen TOPMed
CA387061424 rs1382473194	1194	S>R		No	ClinGen gnomAD
TCGA novel	1195	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848216 rs752745229	1196	F>S		No	ClinGen ExAC gnomAD
CA6848218 rs372569999	1198	S>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA387061457 rs372569999	1198	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs757430426 CA6848220	1201	G>E		No	ClinGen ExAC gnomAD
rs750742100 CA6848222	1202	I>V		No	ClinGen ExAC gnomAD
rs756569830 CA6848224	1207	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA6848225 rs377094070	1209	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1356472325 CA387061537	1210	L>H		No	ClinGen gnomAD
rs777382168 CA6848228 COSM936265	1212	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1199103736 CA387061551	1213	I>L		No	ClinGen gnomAD
CA387061558 rs1344629297	1214	Y>N		No	ClinGen TOPMed
CA387061570 rs1593613431	1215	E>G		No	ClinGen Ensembl
rs995696994 CA244756083	1216	L>R		No	ClinGen Ensembl
rs1555232314 CA387061588	1218	S>*		No	ClinGen Ensembl
CA387061593 rs1187145764	1219	S>P		No	ClinGen gnomAD
CA6848230 rs150106151	1221	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6848248 rs372672248	1226	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1227	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848249 rs200467562	1228	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	1229	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs915532935 CA244756466	1229	Y>H		No	ClinGen gnomAD
TCGA novel	1231	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387061704 rs1593616209	1235	S>G		No	ClinGen Ensembl
CA6848251 rs745582103	1237	P>L		No	ClinGen ExAC gnomAD
rs1324469342 CA387061725	1238	Y>H		No	ClinGen TOPMed
TCGA novel	1239	C>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848252 rs769352525	1239	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1347457643 CA387061738	1240	S>T		No	ClinGen TOPMed gnomAD
CA387061751 rs1468767800	1242	N>D		No	ClinGen TOPMed
rs575582844 CA6848254	1242	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768568451 CA6848255	1243	E>K		No	ClinGen ExAC gnomAD
CA387061784 rs1379375466	1245	D>N		No	ClinGen gnomAD
TCGA novel	1246	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848273 rs185586963	1247	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1593619094 CA387061814	1249	L>F		No	ClinGen Ensembl
rs755726457 CA6848274	1252	I>T		No	ClinGen ExAC gnomAD
CA6848275 rs779631085	1254	S>Y		No	ClinGen ExAC gnomAD
rs749077462 CA6848276	1256	S>C		No	ClinGen ExAC gnomAD
rs577881416 CA6848277	1257	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6848278 rs376432046	1258	L>M		No	ClinGen ESP ExAC gnomAD
CA387061878 rs1377991583	1260	Q>P		No	ClinGen TOPMed gnomAD
CA387061877 rs1377991583	1260	Q>R		No	ClinGen TOPMed gnomAD
CA387061881 rs1235059482	1261	N>H		No	ClinGen TOPMed
rs748027315 CA6848280	1263	Q>E		No	ClinGen ExAC gnomAD
rs748027315 CA387061895	1263	Q>K		No	ClinGen ExAC gnomAD
rs1245546195 CA387061908	1264	E>D		No	ClinGen gnomAD
CA387061907 rs1321219613	1264	E>G		No	ClinGen gnomAD
TCGA novel	1265	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1267765349 CA387061923	1266	S>R		No	ClinGen gnomAD
CA387061938 rs1473123149	1268	W>*		No	ClinGen gnomAD
CA6848281 rs545220073	1269	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs563495095 CA6848284	1270	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA387061952 rs1422740845	1271	A>T		No	ClinGen gnomAD
TCGA novel	1273	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1359621 CA387061975 rs1420018365	1274	F>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA387061988 rs1468850576	1276	V>A		No	ClinGen TOPMed
CA387061986 rs1334173766	1276	V>F		No	ClinGen TOPMed
rs1334173766 CA387061984	1276	V>I		No	ClinGen TOPMed
rs771176050 CA6848285	1277	G>S		No	ClinGen ExAC gnomAD
CA6848286 rs777064738	1279	F>L		No	ClinGen ExAC gnomAD
CA387062030 rs1400807960	1283	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6848288 rs765748060	1284	Q>H		No	ClinGen ExAC gnomAD
rs753136807 CA6848289	1285	H>Q		No	ClinGen ExAC gnomAD
CA387062045 rs1183492622	1285	H>R		No	ClinGen TOPMed gnomAD
rs1593619619 CA387062052	1286	S>C		No	ClinGen Ensembl
CA6848290 rs763478070	1287	V>G		No	ClinGen ExAC gnomAD
CA387062083 rs1316652084	1291	M>L		No	ClinGen TOPMed gnomAD
rs749890970 CA6848292	1292	N>D		No	ClinGen ExAC gnomAD
rs531317872 CA6848293	1292	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA244756891 rs372587320	1294	T>A		No	ClinGen Ensembl
CA387062112 rs1482721043	1295	L>F		No	ClinGen gnomAD
CA6848296 rs754646203	1295	L>S		No	ClinGen ExAC TOPMed gnomAD
rs770173121 CA6848308	1300	F>L		No	ClinGen ExAC TOPMed gnomAD
rs567587924 CA6848310	1303	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848309 rs775931092	1303	T>S		No	ClinGen ExAC gnomAD
CA387062181 rs1424173814	1304	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA387062190 rs1433510666	1305	L>S		No	ClinGen gnomAD
rs1437294108 CA387062194	1306	V>I		No	ClinGen TOPMed
CA387062225 rs1358790423	1310	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA387062229 rs1298878536	1311	V>I		No	ClinGen gnomAD
CA6848315 rs182542690	1312	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6848314 rs370647423	1312	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848313 rs370647423	1312	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848317 rs764879176	1313	M>I		No	ClinGen ExAC gnomAD
CA6848316 rs754554613	1313	M>T		No	ClinGen ExAC gnomAD
CA244757061 rs772290371	1313	M>V		No	ClinGen Ensembl
CA244757067 rs913030692	1314	E>G		No	ClinGen Ensembl
rs1305183774 CA387062276	1318	K>E		No	ClinGen gnomAD
rs979058487 CA244757074	1318	K>N		No	ClinGen TOPMed gnomAD
rs758198302 CA6848319	1321	I>T		No	ClinGen ExAC gnomAD
rs1167993460 CA387062295	1321	I>V		No	ClinGen TOPMed
rs752809151 CA244757079	1323	I>M		No	ClinGen Ensembl
CA6848320 rs201600632	1323	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs148599474 CA244757080	1328	T>A		No	ClinGen 1000Genomes gnomAD
CA6848321 rs545256990	1329	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs557174875 CA6848322	1331	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1593622063 CA387062365	1332	H>L		No	ClinGen Ensembl
CA387062372 rs1258964314	1333	K>R		No	ClinGen gnomAD
CA6848342 COSM936268 rs752336311	1338	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6848343 rs199554625	1338	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1169040821 CA387062429	1340	V>I		No	ClinGen gnomAD
rs372501009 CA6848347	1343	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs368464642 CA6848346	1343	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs751404560 CA6848345 COSM1188645	1343	D>Y	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM1359624 rs745930138 CA6848348	1345	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM4146761 rs1374115321 CA387062469	1346	L>F	thyroid [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA387062464 rs1593627364	1346	L>M		No	ClinGen Ensembl
CA244759908 rs779440210	1347	G>V		No	ClinGen Ensembl
rs1283074136 CA387062480	1348	Y>C		No	ClinGen gnomAD
rs1235026108 CA387062507	1352	L>S		No	ClinGen TOPMed gnomAD
CA6848351 rs749420792	1354	Q>H		No	ClinGen ExAC gnomAD
CA387062520 rs1256033270	1354	Q>P		No	ClinGen gnomAD
CA6848352 rs564690172	1356	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA387062533 rs1414692143	1356	D>H		No	ClinGen gnomAD
CA6848353 rs779078149	1357	V>G		No	ClinGen ExAC gnomAD
rs772551615 CA6848355	1359	E>K		No	ClinGen ExAC gnomAD
CA244759928 rs35806018	1362	W>R		No	ClinGen TOPMed gnomAD
rs1282750877 CA387062582	1363	K>E		No	ClinGen TOPMed
CA6848358 rs369310376	1364	L>F		No	ClinGen ESP ExAC gnomAD
CA6848359 rs775091394	1365	I>T		No	ClinGen ExAC TOPMed gnomAD
rs890879823 CA244759940	1366	D>H		No	ClinGen Ensembl
CA387062611 rs1565993721	1367	K>R		No	ClinGen Ensembl
rs762475893 CA6848360	1368	A>V		No	ClinGen ExAC gnomAD
rs866188207 CA244759955	1370	Q>H		No	ClinGen Ensembl
CA6848362 rs767757962	1373	D>K		No	ClinGen ExAC
CA387062652 COSM275782 rs1398252293	1373	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6848365 rs767558368	1376	L>V		No	ClinGen ExAC gnomAD
rs1355576785 CA387062677	1376	L>W		No	ClinGen gnomAD
rs1285367767 CA387062691	1377	A>T		No	ClinGen gnomAD
rs778074193 CA6848396	1378	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6848397 rs747381203	1379	S>F		No	ClinGen ExAC gnomAD
CA387062711 rs1451398366	1380	L>P		No	ClinGen gnomAD
rs1194650449 CA387062719	1382	G>S		No	ClinGen gnomAD
CA6848398 rs757648651	1383	S>F		No	ClinGen ExAC gnomAD
CA6848400 rs748743485	1384	E>D		No	ClinGen ExAC gnomAD
CA6848399 rs781753461	1384	E>G		No	ClinGen ExAC gnomAD
CA244760220 rs540063427	1385	L>R		No	ClinGen 1000Genomes
rs572769285 CA244760210	1385	L>V		No	ClinGen 1000Genomes
TCGA novel	1386	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1379191961 CA387062743	1386	A>V		No	ClinGen TOPMed gnomAD
rs1453797281 CA387062750	1387	S>I		No	ClinGen gnomAD
rs768254164 CA6848401	1388	L>F		No	ClinGen ExAC TOPMed
CA6848402 COSM936270 rs774019143	1389	Y>C	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6848403 rs774019143	1389	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs771853294 CA6848404	1390	Q>*		No	ClinGen ExAC gnomAD
rs912460940 CA244760232	1391	E>K		No	ClinGen Ensembl
rs773082639 CA6848405	1392	I>V		No	ClinGen ExAC gnomAD
rs760601600 CA6848406	1394	M>V		No	ClinGen ExAC TOPMed gnomAD
CA244760257 rs191910729	1397	K>N		No	ClinGen 1000Genomes TOPMed gnomAD
CA387062812 rs1164803195	1397	K>Q		No	ClinGen TOPMed
CA6848408 COSM1359626 rs566613986	1399	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs759508546 CA6848411	1399	R>H		No	ClinGen ExAC TOPMed gnomAD
rs759508546 CA6848410	1399	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1214764334 CA387062833	1400	E>*		No	ClinGen gnomAD
rs762851601 CA6848413	1400	E>V		No	ClinGen ExAC TOPMed gnomAD
rs758551489 CA6848414	1401	L>F		No	ClinGen ExAC gnomAD
CA6848416 rs376513898	1406	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs376513898 CA6848415	1406	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848417 rs757708469	1408	G>C		No	ClinGen ExAC gnomAD
CA6848418 rs781519591	1409	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6848419 rs746336479	1410	R>C		No	ClinGen ExAC TOPMed gnomAD
CA387062898 rs746336479	1410	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1366701984 CA387062901	1410	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6848420 rs369735435	1412	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA244760284 rs1013068092	1413	K>E		No	ClinGen Ensembl
rs1396449942 CA387062924	1414	L>P		No	ClinGen gnomAD
CA244761406 rs773208953	1416	I>L		No	ClinGen Ensembl
CA6848452 COSM3722312 rs745665785	1417	S>C	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6848453 rs745665785	1417	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs749261940 CA244761409	1420	P>Q		No	ClinGen Ensembl
rs1593639233 CA387062988	1422	F>L		No	ClinGen Ensembl
CA6848455 rs762991897	1427	L>F		No	ClinGen ExAC gnomAD
rs768773060 CA6848456	1428	T>I		No	ClinGen ExAC gnomAD
rs1476788223 CA387063040	1430	K>E		No	ClinGen gnomAD
CA6848458 rs762027879	1430	K>R		No	ClinGen ExAC gnomAD
rs767645076 CA6848459	1431	D>N		No	ClinGen ExAC gnomAD
CA387063060 rs1430034422	1433	I>F		No	ClinGen gnomAD
CA387063059 rs1430034422	1433	I>V		No	ClinGen gnomAD
rs938143715 CA244761414	1435	A>T		No	ClinGen TOPMed
CA6848460 rs750784882	1435	A>V		No	ClinGen ExAC gnomAD
CA6848461 rs761008447	1437	V>L		No	ClinGen ExAC gnomAD
CA387063090 rs1360825229	1438	E>*		No	ClinGen TOPMed
rs1315250012 CA387063096	1439	N>H		No	ClinGen TOPMed
rs754441025 CA6848463	1440	I>M		No	ClinGen ExAC gnomAD
CA6848462 rs766959318	1440	I>V		No	ClinGen ExAC gnomAD
CA6848464 rs374785525	1441	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs200503296 CA244761422	1442	M>K		No	ClinGen ExAC TOPMed gnomAD
rs200503296 CA6848465	1442	M>R		No	ClinGen ExAC TOPMed gnomAD
rs200503296 CA387063119	1442	M>T		No	ClinGen ExAC TOPMed gnomAD
rs896733876 CA244761435	1443	D>N		No	ClinGen gnomAD
CA387063133 rs751039434	1444	T>K		No	ClinGen ExAC gnomAD
rs751039434 CA6848466	1444	T>R		No	ClinGen ExAC gnomAD
rs973177162 CA244761448	1446	L>P		No	ClinGen TOPMed gnomAD
rs1346698482 CA387063159	1448	L>W		No	ClinGen gnomAD
TCGA novel	1452	S>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387063217 rs1468717078	1454	F>C		No	ClinGen gnomAD
CA6848484 rs73407858	1455	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6848485 rs569474522 CA6848486	1455	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1480842065 CA387063229	1456	L>W		No	ClinGen TOPMed
CA6848487 rs750091974	1457	D>A		No	ClinGen ExAC TOPMed gnomAD
rs1410875817 CA387063247	1459	D>N		No	ClinGen gnomAD
CA6848489 rs779785645	1459	D>V		No	ClinGen ExAC gnomAD
CA387063262 rs1395702459	1461	V>F		No	ClinGen gnomAD
CA6848492 rs778782039	1463	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA6848493 rs748225071	1465	F>L		No	ClinGen ExAC gnomAD
CA6848494 rs530384725	1465	F>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs771286904 CA387063293	1466	I>S		No	ClinGen ExAC TOPMed gnomAD
CA6848497 rs771286904	1466	I>T		No	ClinGen ExAC TOPMed gnomAD
rs747192233 CA6848496	1466	I>V		No	ClinGen ExAC TOPMed gnomAD
rs777081250 CA6848498	1468	T>M		No	ClinGen ExAC TOPMed gnomAD
CA6848500 rs765773088	1469	L>M		No	ClinGen ExAC gnomAD
rs1417899482 CA387063311	1469	L>P		No	ClinGen gnomAD
CA387063312 rs1417899482	1469	L>R		No	ClinGen gnomAD
rs775902142 CA6848501	1471	H>R		No	ClinGen ExAC gnomAD
rs766890908 CA6848503	1472	N>K		No	ClinGen ExAC gnomAD
rs761365330 CA387063329	1472	N>S		No	ClinGen ExAC TOPMed gnomAD
rs761365330 CA6848502	1472	N>T		No	ClinGen ExAC TOPMed gnomAD
CA6848504 rs374685449	1473	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs374685449 CA6848505	1473	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1475	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200836404 CA6848508	1476	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1165830833 CA387063358	1477	Q>L		No	ClinGen TOPMed
rs1593648483 CA387063363	1478	G>S		No	ClinGen Ensembl
rs747982808 CA6848510	1478	G>V		No	ClinGen ExAC gnomAD
CA387063372 rs1462936370 COSM1599999	1479	Q>L	central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed
CA387063404 rs777644445	1484	M>L		No	ClinGen ExAC TOPMed gnomAD
CA387063407 rs1181002249	1484	M>T		No	ClinGen TOPMed
rs777644445 CA6848512	1484	M>V		No	ClinGen ExAC TOPMed gnomAD
CA387063431 rs1163059327	1487	A>V		No	ClinGen gnomAD
rs1355792139 CA387063441	1489	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6848514 rs201757501	1489	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs746207263 CA6848516	1490	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM936273 CA6848515 rs369923772	1490	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA387063472 rs775946277	1494	L>H		No	ClinGen ExAC TOPMed gnomAD
rs775946277 CA6848518	1494	L>P		No	ClinGen ExAC TOPMed gnomAD
rs868852678 CA244762607	1496	A>D		No	ClinGen Ensembl
rs768470799 CA244762602	1496	A>P		No	ClinGen Ensembl
CA387063486 rs1215084868	1497	K>R		No	ClinGen TOPMed
rs772694843 CA6848522 COSM225008	1499	L>F	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA387063500 rs1275307801	1499	L>R		No	ClinGen gnomAD
rs772694843 CA6848521	1499	L>V		No	ClinGen ExAC gnomAD
rs765984749 CA387063501	1500	E>K		No	ClinGen ExAC gnomAD
CA6848523 rs765984749	1500	E>Q		No	ClinGen ExAC gnomAD
CA387063513 rs1258893868	1501	M>I		No	ClinGen gnomAD
rs753535230 CA6848524	1501	M>V		No	ClinGen ExAC gnomAD
CA6848526 rs35315099 VAR_051084	1506	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6848529 rs758214565	1508	T>A		No	ClinGen ExAC gnomAD
rs1168153376 CA387063562	1509	K>R		No	ClinGen gnomAD
rs900562877 CA244762667	1510	D>N		No	ClinGen TOPMed
TCGA novel	1510	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848530 rs186936079	1511	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM249529 CA6848531 rs75696429	1512	V>G	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA387063586 rs1376047296	1513	I>F		No	ClinGen gnomAD
CA387063595 rs1438976869	1514	S>I		No	ClinGen TOPMed
rs188333792 CA6848533	1515	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387063605 rs1325652304	1516	S>G		No	ClinGen gnomAD
rs868009939 CA244762690	1517	G>E		No	ClinGen Ensembl
rs1227804932 CA387063623	1518	I>M		No	ClinGen gnomAD
rs1272212082 CA387063628	1519	L>R		No	ClinGen gnomAD
rs373258279 CA6848537	1520	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs377338340 CA6848538	1521	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848545 rs141319247	1523	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA244764850 rs188264424	1526	D>N		No	ClinGen 1000Genomes TOPMed gnomAD
rs764096706 CA6848547	1527	Y>D		No	ClinGen ExAC gnomAD
CA387063714 rs1312190763 COSM3688005	1529	M>I	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs757284102 CA6848549	1532	V>D		No	ClinGen ExAC gnomAD
rs751600300 CA6848548	1532	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1454217351 CA387063734	1533	V>I		No	ClinGen TOPMed gnomAD
CA244764857 rs1051571885	1537	I>L		No	ClinGen TOPMed gnomAD
rs1398121818 CA387063765	1537	I>R		No	ClinGen TOPMed
TCGA novel	1537	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA244764862 rs796953117	1539	R>*		No	ClinGen TOPMed
rs537391298 CA244764864	1539	R>Q		No	ClinGen 1000Genomes
CA244764868 rs896655166	1541	D>G		No	ClinGen TOPMed
CA387063803 rs1392271520	1543	K>R		No	ClinGen TOPMed
CA387063829 rs1444121348	1547	I>V		No	ClinGen TOPMed
rs1326837305 CA387063844	1549	I>V		No	ClinGen gnomAD
CA387063854 rs1373465332	1550	N>S		No	ClinGen gnomAD
rs1243648979 CA387063861	1551	Q>P		No	ClinGen TOPMed
rs1593661178 CA387063904	1552	A>P		No	ClinGen Ensembl
rs1295464894 CA387063921	1554	S>G		No	ClinGen gnomAD
rs761777471 CA6848569	1555	I>F		No	ClinGen ExAC gnomAD
TCGA novel	1556	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1250360699 CA387063972	1558	H>R		No	ClinGen TOPMed gnomAD
CA6848570 rs767576864	1559	L>*		No	ClinGen ExAC gnomAD
CA6848572 rs756256949	1561	S>L		No	ClinGen ExAC TOPMed
CA387064014 rs1467714969	1562	Y>H		No	ClinGen TOPMed
rs754043201 CA6848574	1563	R>G		No	ClinGen ExAC gnomAD
CA387064055 rs1188442301	1565	I>M		No	ClinGen gnomAD
CA244765324 rs368101210	1567	P>L		No	ClinGen ESP TOPMed
rs755219785 CA6848575	1567	P>S		No	ClinGen ExAC TOPMed gnomAD
CA6848576 rs779178448	1568	P>T		No	ClinGen ExAC gnomAD
CA387064072 rs371479973	1569	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848578 rs371479973	1569	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA244765330 rs1051325845	1570	D>G		No	ClinGen TOPMed
rs1256517743 CA387064088	1572	E>K		No	ClinGen TOPMed
rs1311120129 CA387064101	1573	Y>C		No	ClinGen gnomAD
CA6848580 rs745341317	1574	Q>H		No	ClinGen ExAC gnomAD
CA387064151 rs1479427306	1580	V>I		No	ClinGen TOPMed
CA244765346 rs999109760	1581	I>V		No	ClinGen TOPMed gnomAD
CA6848581 rs769398897	1582	T>N		No	ClinGen ExAC gnomAD
CA387064171 rs1294494775	1583	L>S		No	ClinGen gnomAD
CA6848585 rs543461396	1586	A>P		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1587	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs555365524 CA6848587	1592	P>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1594	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387064256 rs1300425498	1596	I>M		No	ClinGen TOPMed
CA387064258 rs760551034	1597	F>I		No	ClinGen ExAC gnomAD
CA6848589 rs760551034	1597	F>L		No	ClinGen ExAC gnomAD
CA387064266 rs1281826815	1598	F>L		No	ClinGen gnomAD
CA6848590 rs766442610	1603	N>K		No	ClinGen ExAC gnomAD
TCGA novel	1604	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767528355 CA244765384	1605	W>C		No	ClinGen Ensembl
CA6848591 rs752554885	1606	K>E		No	ClinGen ExAC gnomAD
COSM936275 rs755131976 CA6848592	1608	L>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6848607 rs771850728	1610	T>A		No	ClinGen ExAC gnomAD
CA6848608 rs772911607	1610	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1612	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848610 rs369840547	1613	S>C		No	ClinGen ESP ExAC gnomAD
rs776756136 CA6848611	1613	S>N		No	ClinGen ExAC gnomAD
TCGA novel	1615	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848615 rs763188648	1624	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1288841206 CA387064477	1627	M>I		No	ClinGen gnomAD
CA387064499 rs1271079700	1629	F>I		No	ClinGen gnomAD
rs1040371294 CA244765562 CA387064505	1629	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
rs377556294 CA6848636	1633	T>S		No	ClinGen ESP ExAC gnomAD
CA244765567 rs1051942278	1634	L>P		No	ClinGen TOPMed
rs1419058716 CA387064541	1635	Y>*		No	ClinGen TOPMed gnomAD
rs1593662346 CA387064544	1636	V>M		No	ClinGen Ensembl
rs1164639248 COSM1359629 CA387064560	1639	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	1641	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756718707 CA6848640	1642	V>G		No	ClinGen ExAC gnomAD
CA387064582 rs1247882200	1642	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs372567149 CA6848641	1643	F>C		No	ClinGen ESP ExAC gnomAD
TCGA novel	1644	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758051779 CA6848643	1644	E>K		No	ClinGen ExAC TOPMed gnomAD
CA387064617 rs777353240	1646	K>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1646	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371016706 CA6848646	1650	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA387064668 rs1276630633	1654	L>*		No	ClinGen TOPMed
CA6848649 rs117543414	1656	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs117543414 CA6848648	1656	Q>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA244765606 rs376125787	1658	K>E		No	ClinGen ESP TOPMed gnomAD
rs374789933 CA6848652	1660	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848653 rs774478500	1661	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6848654 rs762115301	1661	T>K		No	ClinGen ExAC TOPMed gnomAD
CA387064711 rs1414626170	1662	L>M		No	ClinGen TOPMed
CA387064728 rs1426859546	1664	N>I		No	ClinGen TOPMed
rs1013795802 CA244765618	1664	N>K		No	ClinGen TOPMed gnomAD
TCGA novel	1667	I>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848657 rs773715097	1667	I>L		No	ClinGen ExAC gnomAD
CA6848656 rs773715097	1667	I>V		No	ClinGen ExAC gnomAD
rs1432263332 CA387064756	1668	T>S		No	ClinGen gnomAD
CA6848659 rs752247676	1671	T>M		No	ClinGen ExAC TOPMed gnomAD
CA6848661 rs763782509	1672	Q>H		No	ClinGen ExAC gnomAD
rs751126982 CA6848662	1673	T>A		No	ClinGen ExAC gnomAD
CA387064796 rs1236018749	1675	E>K		No	ClinGen TOPMed
rs1024816135 CA244765648	1677	C>F		No	ClinGen TOPMed gnomAD
rs1443166526 CA387064818	1678	L>V		No	ClinGen TOPMed
rs367958993 CA6848667	1680	S>C		No	ClinGen ESP ExAC gnomAD
CA387064832 rs1368874405	1680	S>P		No	ClinGen gnomAD
CA6848664 rs367958993	1680	S>Y		No	ClinGen ESP ExAC gnomAD
CA387064834 rs1233647385	1681	I>L		No	ClinGen gnomAD
rs969847050 CA244765691	1681	I>M		No	ClinGen TOPMed gnomAD
CA387064835 rs1233647385	1681	I>V		No	ClinGen gnomAD
rs770283547 CA244765693	1683	N>I		No	ClinGen gnomAD
CA387064858 rs1347724828	1684	P>Q		No	ClinGen gnomAD
CA387064860 rs1203800403	1685	E>K		No	ClinGen gnomAD
CA387064874 rs1284052777	1686	W>*		No	ClinGen gnomAD
rs371889114 CA244765697	1687	A>V		No	ClinGen ESP TOPMed
rs192721169 CA6848668	1688	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387064896 rs1188819113	1689	A>G		No	ClinGen gnomAD
CA387064902 rs1593662767	1690	I>V		No	ClinGen Ensembl
CA6848669 rs373590239	1692	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA387064930 rs1452105518	1693	S>R		No	ClinGen gnomAD
CA387064936 rs1555237278	1693	S>T		No	ClinGen Ensembl
CA6848670 rs368892317	1696	Q>R		No	ClinGen ESP ExAC gnomAD
CA244766302 rs931153925	1702	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA387065893 rs750218882	1706	S>A		No	ClinGen ExAC TOPMed gnomAD
CA6848697 rs750218882	1706	S>P		No	ClinGen ExAC TOPMed gnomAD
CA6848698 rs750218882	1706	S>T		No	ClinGen ExAC TOPMed gnomAD
CA6848700 rs779947040	1710	F>C		No	ClinGen ExAC TOPMed
CA387065942 rs1328858161 COSM692567	1710	F>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA387065965 rs1048797856	1711	C>*		No	ClinGen gnomAD
CA387065961 rs1474652980	1711	C>F		No	ClinGen TOPMed
CA6848701 rs201877014	1712	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA6848702 rs754945133	1715	A>V		No	ClinGen ExAC gnomAD
CA387066021 rs1282642772	1716	E>K		No	ClinGen gnomAD
rs868777106 CA244766324	1718	W>*		No	ClinGen TOPMed gnomAD
rs1243628491 CA387066048	1718	W>R		No	ClinGen gnomAD
CA6848705 rs202181687	1720	Q>K		No	ClinGen 1000Genomes ExAC gnomAD
CA6848706 rs778179972	1721	N>T		No	ClinGen ExAC TOPMed gnomAD
rs747353989 CA6848707	1722	I>N		No	ClinGen ExAC
CA6848708 rs771375125	1723	P>A		No	ClinGen ExAC gnomAD
rs777086152 CA6848709	1723	P>L		No	ClinGen ExAC gnomAD
CA387066127 rs759894811	1724	S>*		No	ClinGen ExAC gnomAD
CA6848710 rs759894811	1724	S>L		No	ClinGen ExAC gnomAD
CA387066140 rs1370413342	1725	Q>R		No	ClinGen gnomAD
rs983949034	1726	D>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs772711216 CA6848733	1726	D>Y		No	ClinGen ExAC
CA387066215 rs1380193596	1727	E>K		No	ClinGen TOPMed gnomAD
CA6848734 rs559013460	1729	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848735 rs766109359 COSM430581	1729	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6848736 rs369189727	1732	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs759415897 CA6848737	1733	E>K		No	ClinGen ExAC TOPMed gnomAD
CA387066316 rs1257576044	1735	L>V		No	ClinGen gnomAD
TCGA novel	1736	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387066341 rs1484736662	1737	K>Q		No	ClinGen gnomAD
CA6848739 rs752631947	1738	K>Q		No	ClinGen ExAC gnomAD
rs759672184 CA6848740	1740	H>R		No	ClinGen ExAC gnomAD
rs1425128748 CA387066406	1741	I>S		No	ClinGen gnomAD
CA6848743 rs757408657	1742	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA6848741 rs764204931	1742	Q>K		No	ClinGen ExAC
rs751702711 CA6848742	1742	Q>R		No	ClinGen ExAC TOPMed
rs756553539 CA6848746	1744	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA6848745 rs746190485	1744	R>W		No	ClinGen ExAC gnomAD
rs966574653 CA244766522	1745	R>*		No	ClinGen TOPMed gnomAD
CA6848747 rs780306479	1745	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA387066461 rs749726386	1746	S>L		No	ClinGen ExAC TOPMed gnomAD
CA6848748 rs749726386	1746	S>W		No	ClinGen ExAC TOPMed gnomAD
CA387066475 rs1272541364	1748	T>P		No	ClinGen gnomAD
CA387066507 rs1219751774	1750	A>V		No	ClinGen gnomAD
CA387066515 rs1314977511	1751	V>A		No	ClinGen gnomAD
CA6848750 rs151223138	1751	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs151223138 CA387066509	1751	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1269059157 CA387066547	1754	A>S		No	ClinGen gnomAD
CA387066577 rs1212011326	1756	K>N		No	ClinGen gnomAD
rs373134120 CA6848754	1757	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1052613813 CA244766557	1758	N>D		No	ClinGen Ensembl
rs893531873 CA244766561	1759	T>A		No	ClinGen Ensembl
CA6848756 rs775432207	1760	E>*		No	ClinGen ExAC gnomAD
rs775432207 CA387066613	1760	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA387066627 rs1396252480	1761	E>K		No	ClinGen TOPMed
CA6848758 rs764186570	1765	V>L		No	ClinGen ExAC gnomAD
rs757403061 COSM384606 CA6848760	1767	G>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA387066751 rs1555237885	1771	H>Y		No	ClinGen Ensembl
CA6848765 rs749708041	1775	S>G		No	ClinGen ExAC gnomAD
CA6848766 rs755470402	1776	L>P		No	ClinGen ExAC gnomAD
rs1593666545 CA387066834	1777	Y>F		No	ClinGen Ensembl
rs542508586 CA6848768	1778	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs770425941 CA6848769	1780	P>R		No	ClinGen ExAC TOPMed gnomAD
CA6848771 rs376028299	1783	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA387066921 rs1231728317	1784	Q>K		No	ClinGen gnomAD
CA387066929 rs1593666618	1784	Q>R		No	ClinGen Ensembl
CA244766642 rs930721252	1785	R>G		No	ClinGen TOPMed
COSM282300 rs1475420874 CA387066944	1785	R>I	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6848773 rs769346521	1787	Q>E		No	ClinGen ExAC gnomAD
rs775412077 CA6848774	1789	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1555237911 CA387067018	1791	G>V		No	ClinGen Ensembl
rs762907888 CA387067034	1793	D>A		No	ClinGen ExAC TOPMed gnomAD
CA6848775 rs762907888	1793	D>G		No	ClinGen ExAC TOPMed gnomAD
CA387067052 rs1270558933	1794	Y>F		No	ClinGen TOPMed
rs1555237923 CA387067071	1796	D>N		No	ClinGen Ensembl
CA387067143 rs1333224278	1797	I>T		No	ClinGen gnomAD
CA387067150 rs1156984907	1798	H>Y		No	ClinGen TOPMed
CA387067168 rs1400253612	1799	A>V		No	ClinGen TOPMed
rs749072956 CA6848792	1800	A>T		No	ClinGen ExAC gnomAD
CA6848793 rs768527036	1800	A>V		No	ClinGen ExAC gnomAD
rs1415936427 CA387067183	1801	A>P		No	ClinGen gnomAD
TCGA novel	1803	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848794 rs774321818	1803	E>V		No	ClinGen ExAC gnomAD
CA6848795 rs761745919	1804	I>V		No	ClinGen ExAC TOPMed gnomAD
rs529981688 COSM1359633 CA6848797	1806	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1194057844 CA387067277	1808	N>S		No	ClinGen TOPMed
rs1258642780 CA387067414	1818	M>I		No	ClinGen TOPMed
rs766562256 CA6848800	1819	L>F		No	ClinGen ExAC gnomAD
CA387067421 rs1214447171	1819	L>M		No	ClinGen TOPMed
CA6848801 rs754010103	1821	E>Q		No	ClinGen ExAC gnomAD
CA6848802 rs571378777	1823	W>*		No	ClinGen ExAC TOPMed gnomAD
CA387067484 rs1391993775	1823	W>*		No	ClinGen gnomAD
rs373558832 CA244766879	1824	L>R		No	ClinGen ESP TOPMed gnomAD
rs753014976 CA6848804	1825	C>R		No	ClinGen ExAC TOPMed gnomAD
rs1318851688 CA387067517	1826	P>L		No	ClinGen gnomAD
CA244766886 rs770086755	1826	P>S		No	ClinGen Ensembl
rs749919389 CA6848807	1828	T>A		No	ClinGen ExAC gnomAD
CA244766894 rs1052077489	1828	T>I		No	ClinGen TOPMed
CA6848808 rs755737986	1829	K>E		No	ClinGen ExAC gnomAD
CA387067555 rs1430283227	1830	P>A		No	ClinGen TOPMed
rs7310898 CA6848809 VAR_051085	1830	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1490630197 CA387068539	1834	P>L		No	ClinGen TOPMed
rs751966081 CA6848825	1835	S>*		No	ClinGen ExAC gnomAD
CA387068549 rs757874880	1836	E>A		No	ClinGen ExAC gnomAD
rs757874880 CA6848826	1836	E>V		No	ClinGen ExAC gnomAD
CA6848827 rs765923213	1837	L>S		No	ClinGen ExAC gnomAD
CA6848828 rs753416151	1838	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1184329807 CA387068567	1839	E>Q		No	ClinGen gnomAD
rs889169995 CA244772219	1841	Q>*		No	ClinGen TOPMed
CA387068581 rs889169995	1841	Q>E		No	ClinGen TOPMed
CA6848829 rs754669999	1842	E>K		No	ClinGen ExAC gnomAD
CA387068601 rs1457514515	1843	D>E		No	ClinGen gnomAD
CA6848831 rs778467386	1845	A>D		No	ClinGen ExAC TOPMed gnomAD
rs778467386 CA6848830	1845	A>V		No	ClinGen ExAC TOPMed gnomAD
rs758075908 CA6848832	1847	R>*		No	ClinGen ExAC gnomAD
CA6848833 COSM936279 rs202054994	1847	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1456539506 CA387068646	1849	V>A		No	ClinGen TOPMed
CA6848860 rs563069855	1850	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
CA387068659 rs1482772863	1851	Y>C		No	ClinGen gnomAD
CA6848863 rs745926545	1854	L>P		No	ClinGen ExAC gnomAD
rs374343598 CA6848865	1855	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs769714305 CA6848864	1855	S>P		No	ClinGen ExAC gnomAD
rs1174501490 CA387068682	1856	R>C		No	ClinGen gnomAD
CA6848866 rs367873698 COSM936280	1856	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA387068685 rs367873698	1856	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1407816003 CA387068696	1858	I>T		No	ClinGen gnomAD
rs768939060 CA6848867	1858	I>V		No	ClinGen ExAC gnomAD
rs549074031 CA6848869	1859	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848868 rs774847008	1859	D>Y		No	ClinGen ExAC gnomAD
CA387068708 rs930931941	1860	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA244773399 rs930931941	1860	Y>F		No	ClinGen TOPMed
CA6848870 rs772681792	1860	Y>H		No	ClinGen ExAC gnomAD
rs371795435 CA6848871	1866	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1346903835 CA387068757	1867	V>A		No	ClinGen gnomAD
CA387068785 rs578088874	1872	T>A		No	ClinGen TOPMed gnomAD
rs578088874 CA244773405	1872	T>P		No	ClinGen TOPMed gnomAD
CA6848872 rs761271707	1874	T>A		No	ClinGen ExAC TOPMed gnomAD
CA6848873 rs764584293	1874	T>N		No	ClinGen ExAC gnomAD
CA387069430 rs1465967227	1877	G>S		No	ClinGen gnomAD
CA387069455 rs1181100198	1878	M>I		No	ClinGen gnomAD
rs1472430896 CA387069444	1878	M>V		No	ClinGen TOPMed gnomAD
rs550193120 CA244774852	1880	Q>K		No	ClinGen 1000Genomes TOPMed gnomAD
rs1387551839 CA387069525	1882	T>I		No	ClinGen gnomAD
rs372450429 CA6848896	1884	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6848897 rs762564992	1887	T>A		No	ClinGen ExAC gnomAD
rs185213045 CA6848898	1888	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1371853741 CA387069656	1891	Q>R		No	ClinGen gnomAD
CA244774860 rs941483494	1892	C>Y		No	ClinGen TOPMed gnomAD
CA6848899 rs751166784	1894	F>L		No	ClinGen ExAC gnomAD
CA6848901 rs767236759	1895	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6848900 rs761485749	1895	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs563941779 CA6848902	1897	A>S		No	ClinGen ExAC gnomAD
CA6848903 rs755995647	1898	D>G		No	ClinGen ExAC gnomAD
CA387069756 rs1289273519	1900	E>K		No	ClinGen gnomAD
rs753836417 CA6848905	1902	I>M		No	ClinGen ExAC TOPMed gnomAD
rs931916476 CA244774897	1902	I>V		No	ClinGen TOPMed gnomAD
rs779163066 CA6848907	1904	S>P		No	ClinGen ExAC gnomAD
CA6848908 rs748310550	1904	S>Y		No	ClinGen ExAC gnomAD
rs1482968730 CA387069810	1905	L>V		No	ClinGen gnomAD
rs1555239969 CA387069819	1906	F>L		No	ClinGen Ensembl
rs778267811 CA6848910	1907	K>*		No	ClinGen ExAC gnomAD
CA387069866 rs1470978655	1910	I>T		No	ClinGen gnomAD
rs535800130 CA6848912	1913	V>G		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1913	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6848925 rs546052261	1915	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs758689741 CA6848927	1917	L>S		No	ClinGen ExAC gnomAD
rs564272380 CA6848926	1917	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	1918	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778180060 CA6848928	1919	C>R		No	ClinGen ExAC gnomAD
rs747314540 CA6848929	1919	C>Y		No	ClinGen ExAC gnomAD
rs1318660800 CA387070014	1921	T>A		No	ClinGen gnomAD
CA244775229 rs941338409	1922	F>S		No	ClinGen TOPMed gnomAD
CA387070047 rs1339142824	1924	A>V		No	ClinGen TOPMed
TCGA novel	1925	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387070086 rs1343380497	1928	T>A		No	ClinGen gnomAD
rs1262162347 CA387070134	1932	P>S		No	ClinGen gnomAD
rs757593737 CA6848930	1935	Y>C		No	ClinGen ExAC gnomAD
rs975917410 CA244775274	1936	E>K		No	ClinGen Ensembl
rs770302256 CA6848934	1938	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1476948976 CA387070230	1942	P>L		No	ClinGen gnomAD
CA387070233 rs1593683160	1943	K>E		No	ClinGen Ensembl
CA387070235 rs1429688832	1943	K>R		No	ClinGen gnomAD
CA387070247 rs1326790260	1945	G>R		No	ClinGen TOPMed
CA387070254 rs1593683183	1946	M>V		No	ClinGen Ensembl
CA387070263 rs1166647148	1947	I>V		No	ClinGen Ensembl
CA387070308 rs1593683208	1953	N>T		No	ClinGen Ensembl
CA6848937 rs771686077	1954	H>P		No	ClinGen ExAC gnomAD
CA6848938 rs772868295	1955	S>N		No	ClinGen ExAC gnomAD
rs766129434 CA6848940	1956	H>R		No	ClinGen ExAC TOPMed gnomAD
rs760272902 CA6848939	1956	H>Y		No	ClinGen ExAC TOPMed
rs759532010 COSM261707 CA6848942	1957	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765331209 CA6848943	1958	S>C		No	ClinGen ExAC gnomAD
rs1050913636 CA244775341	1959	M>V		No	ClinGen TOPMed gnomAD
CA244776402 rs941657022	1960	A>T		No	ClinGen Ensembl
CA387070449 rs1221739081	1963	L>M		No	ClinGen gnomAD
CA6848959 rs746612190	1964	V>A		No	ClinGen ExAC gnomAD
CA6848958 rs777150263	1964	V>M		No	ClinGen ExAC TOPMed gnomAD
CA387070468 rs1202718952	1965	T>A		No	ClinGen TOPMed gnomAD
rs1202718952 CA387070470	1965	T>S		No	ClinGen TOPMed gnomAD
CA387070522 rs1419917111	1970	E>Q		No	ClinGen gnomAD
rs1366801672 CA387070539	1971	Y>F		No	ClinGen gnomAD
rs201126027 CA244776445	1971	Y>H		No	ClinGen 1000Genomes
rs200898021 CA6848963	1974	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6848964 rs376634701	1976	L>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs944298357 CA244776474	1977	Q>*		No	ClinGen gnomAD
CA387070641 rs1397602245	1980	N>K		No	ClinGen gnomAD
CA387070638 rs1297157195	1980	N>S		No	ClinGen TOPMed
rs1395569241 CA387070658	1982	L>H		No	ClinGen gnomAD
CA6848966 rs764170655	1984	Q>*		No	ClinGen ExAC TOPMed gnomAD
COSM1193296 CA6848967 rs574096690	1986	L>F	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1566018655 CA387070703	1986	L>R		No	ClinGen Ensembl
CA6848968 rs371165754	1987	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs373000158 CA6848969	1990	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750759642 CA6848970	1991	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1305088197 CA387070804	1992	I>M		No	ClinGen TOPMed
rs1391708995 CA387070797	1992	I>V		No	ClinGen TOPMed
CA387070936 rs1379649718	2004	S>I		No	ClinGen TOPMed
rs974198395 CA244776814	2004	S>R		No	ClinGen TOPMed
rs201035166 CA6848979	2005	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387070957 rs929054140	2006	H>P		No	ClinGen TOPMed gnomAD
CA244776825 rs929054140	2006	H>R		No	ClinGen TOPMed gnomAD
rs1375782753 CA387070954	2006	H>Y		No	ClinGen TOPMed
CA387070989 rs1307918319	2009	W>*		No	ClinGen gnomAD
CA387071152 rs1408082244	2013	Y>H		No	ClinGen gnomAD
rs375695284 CA387071170	2015	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs375695284 CA6849002	2015	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6849003 rs768610076	2016	K>T		No	ClinGen ExAC gnomAD
rs368483300 CA6849004	2017	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs748143502 CA6849005	2017	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA244779441 rs372428419	2019	Q>R		No	ClinGen ESP TOPMed gnomAD
CA6849007 rs773290474	2020	R>C		No	ClinGen ExAC gnomAD
rs375343576 CA6849008	2020	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs375343576 CA6849009	2020	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6849010 rs11837038 VAR_051086	2021	V>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs759866115 CA6849011	2022	I>V		No	ClinGen ExAC gnomAD
rs1243844350 CA387071216	2023	Q>E		No	ClinGen TOPMed gnomAD
CA387071220 rs1315017017	2023	Q>R		No	ClinGen gnomAD
CA244779486 rs888128043	2024	I>M		No	ClinGen TOPMed gnomAD
rs1360831724 CA387071232	2025	P>Q		No	ClinGen gnomAD
rs753104607 CA6849013	2026	L>M		No	ClinGen ExAC gnomAD
rs1421337817 CA387071274	2030	S>F		No	ClinGen gnomAD
rs764767020 CA6849043	2031	C>F		No	ClinGen ExAC gnomAD
CA387071290 rs1295036431	2033	L>*		No	ClinGen TOPMed
rs755737784 CA6849045	2035	P>A		No	ClinGen ExAC gnomAD
CA387071307 rs1451235839	2035	P>L		No	ClinGen TOPMed
CA387071304 rs755737784	2035	P>S		No	ClinGen ExAC gnomAD
CA387071323 rs1432065850	2037	Q>H		No	ClinGen gnomAD
CA387071327 rs1272298085	2038	L>P		No	ClinGen gnomAD
rs989486439 CA244779723	2041	C>G		No	ClinGen Ensembl
rs961447821 CA244779724	2046	I>T		No	ClinGen TOPMed
rs1262117437 CA387071380	2046	I>V		No	ClinGen gnomAD
CA387071384 rs1201652948	2047	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6849046 rs151134699	2048	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6849048 rs528094170	2050	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387071427 rs1455044555	2051	C>W		No	ClinGen gnomAD
rs751430815 CA6849076	2055	G>C		No	ClinGen ExAC gnomAD
TCGA novel	2055	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA387071460 rs1388164722	2055	G>V		No	ClinGen gnomAD
rs1326427816 CA387071463	2056	D>N		No	ClinGen gnomAD
CA6849078 rs757199881	2059	L>V		No	ClinGen ExAC gnomAD
CA6849079 rs560306260	2060	I>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387071516 rs780374419	2061	G>*		No	ClinGen ExAC TOPMed gnomAD
rs780374419 CA6849081	2061	G>R		No	ClinGen ExAC TOPMed gnomAD
rs769105761 CA244781287	2063	A>S		No	ClinGen ExAC TOPMed gnomAD
rs769105761 CA6849083	2063	A>T		No	ClinGen ExAC TOPMed gnomAD
CA387071563 rs1396063247	2066	Y>C		No	ClinGen TOPMed
rs1175802785 CA387071570	2067	I>L		No	ClinGen TOPMed
CA6849085 rs377336279	2072	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6849087 rs370269719	2072	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6849084 rs377336279	2072	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6849086 rs377336279	2072	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs759133271 CA387071640	2073	A>G		No	ClinGen ExAC TOPMed gnomAD
rs759133271 CA6849088	2073	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6849091 rs752304640	2075	A>V		No	ClinGen ExAC gnomAD
rs1370618254 CA387071688	2077	A>V		No	ClinGen gnomAD
rs751404199 CA6849094	2078	C>*		No	ClinGen ExAC TOPMed gnomAD
CA244781354 rs1026377702	2078	C>S		No	ClinGen TOPMed
rs750453851 CA6849097	2082	M>R		No	ClinGen ExAC gnomAD
CA6849096 rs767556658	2082	M>V		No	ClinGen ExAC gnomAD
rs756158800 CA6849098	2083	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs779999542 CA6849099	2084	H>N		No	ClinGen ExAC gnomAD
TCGA novel	2085	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6849101 rs755269609	2086	E>*		No	ClinGen ExAC gnomAD
CA6849102 rs368756882	2087	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1200686818 CA387071900	2090	Q>R		No	ClinGen gnomAD
rs1566023288 CA387071923	2092	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1218247088 CA387071949	2093	K>R		No	ClinGen TOPMed gnomAD
CA6849118 rs755251263	2094	N>Y		No	ClinGen ExAC gnomAD
TCGA novel	2096	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195453661 CA387072174	2099	C>G		No	ClinGen gnomAD
rs367860451 CA6849120	2102	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1027418383 CA244782381	2103	V>A		No	ClinGen TOPMed
CA6849121 rs186319199	2103	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387072226 rs186319199	2103	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs186319199 CA387072224	2103	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1180117195 CA387072245	2105	L>V		No	ClinGen TOPMed
CA244782389 rs944395463	2111	H>L		No	ClinGen Ensembl
rs910239224 CA244782385	2111	H>N		No	ClinGen Ensembl
rs778031720 CA6849122	2112	M>I		No	ClinGen ExAC gnomAD
TCGA novel	2112	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6849123 rs375970712	2113	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6849124 rs771390477 COSM936283	2114	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771390477 CA387072371	2114	T>R		No	ClinGen ExAC TOPMed gnomAD
rs748863249 CA6849126	2115	G>R		No	ClinGen ExAC gnomAD
TCGA novel	2115	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1434971875 CA387072381	2116	Q>*		No	ClinGen gnomAD
rs773933138 CA6849128	2119	G>V		No	ClinGen ExAC gnomAD
CA6849130 rs767299452	2120	F>L		No	ClinGen ExAC gnomAD
CA387072440 rs1315191457	2121	S>A		No	ClinGen gnomAD
rs1052604960 CA244782459	2122	H>Y		No	ClinGen TOPMed gnomAD
rs772901770 CA6849131	2123	Q>E		No	ClinGen ExAC gnomAD
CA387072840 rs1360602448	2124	I>M		No	ClinGen gnomAD
rs778177496 CA6849141	2125	R>G		No	ClinGen ExAC gnomAD
rs1234108799 CA387072859	2126	S>N		No	ClinGen gnomAD
CA387072853 rs1248061743	2126	S>R		No	ClinGen gnomAD
CA244782855 rs893995810	2128	I>M		No	ClinGen Ensembl
CA6849143 rs757777671	2131	N>S		No	ClinGen ExAC gnomAD
rs781706275 CA6849144	2133	I>V		No	ClinGen ExAC gnomAD
CA6849145 rs375738921	2134	N>S		No	ClinGen ExAC gnomAD
TCGA novel	2135	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1384455918 CA387072989	2136	K>*		No	ClinGen gnomAD
rs1349692301 CA387073035	2139	G>R		No	ClinGen TOPMed
CA387073029 rs1349692301	2139	G>W		No	ClinGen TOPMed
TCGA novel	2140	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6849147 rs768085665	2140	I>T		No	ClinGen ExAC gnomAD
CA6849148 rs778423506	2141	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1425795357 CA387073077	2143	K>E		No	ClinGen TOPMed
CA387073101 rs1178254213	2145	K>E		No	ClinGen TOPMed
rs771666485 CA387073106	2145	K>R		No	ClinGen ExAC TOPMed gnomAD
rs771666485 CA6849150	2145	K>T		No	ClinGen ExAC TOPMed gnomAD
CA387073123 rs1332134652	2146	Y>*		No	ClinGen gnomAD
rs773059288 CA6849152	2148	Q>E		No	ClinGen ExAC
rs1593700178 CA387073189	2151	K>R		No	ClinGen Ensembl
rs1379135018 CA387073202	2152	M>T		No	ClinGen gnomAD
CA6849153 rs760448774	2154	A>V	Variant assessed as Somatic; 5.444e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1380399900 CA387073249	2156	N>D		No	ClinGen gnomAD
CA387073270 rs1230362396	2157	T>I		No	ClinGen gnomAD
CA6849155 rs776645941	2158	N>S		No	ClinGen ExAC TOPMed gnomAD
CA6849156 rs759579256	2159	N>S		No	ClinGen ExAC gnomAD
rs1481570192 CA387073300	2160	I>V		No	ClinGen gnomAD
rs1258154886 CA387073313	2161	T>A		No	ClinGen gnomAD
rs1258154886 CA387073312	2161	T>P		No	ClinGen gnomAD
CA387073320 rs1458702457	2162	E>*		No	ClinGen gnomAD
CA244782899 rs865850354	2162	E>D		No	ClinGen Ensembl
rs942713528 CA244782916	2168	A>T		No	ClinGen TOPMed gnomAD
rs752769547 CA6849158	2169	N>D		No	ClinGen ExAC gnomAD
rs763204458 CA6849159	2170	D>E		No	ClinGen ExAC gnomAD
CA6849161 rs541055107	2171	L>I		No	ClinGen 1000Genomes ExAC TOPMed
CA244784461 rs556830713	2172	S>R		No	ClinGen Ensembl
rs770812752 CA6849179	2173	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1404169360 CA387074023	2174	D>G		No	ClinGen gnomAD
COSM546880 CA6849180 rs776590958	2176	A>T	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA387074070 rs1323493661	2176	A>V		No	ClinGen TOPMed gnomAD
rs1566026462 CA387074075	2177	S>P		No	ClinGen Ensembl
rs745779007 CA387074092	2178	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6849182 rs745779007	2178	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1300386943 CA387074140	2180	I>M		No	ClinGen gnomAD
CA6849185 rs762999729	2180	I>T		No	ClinGen ExAC gnomAD
CA6849184 rs199778988	2180	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1327325647 CA387074151	2181	T>S		No	ClinGen Ensembl
TCGA novel	2184	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1221238034 CA387074185	2184	S>L		No	ClinGen gnomAD
rs377549886 CA6849186	2184	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA6849187 rs774367572	2185	K>E		No	ClinGen ExAC TOPMed gnomAD
rs762051647 CA6849188	2185	K>N		No	ClinGen ExAC gnomAD
CA244784549 rs923310288	2185	K>R		No	ClinGen Ensembl
CA387074225 rs1220946589	2187	C>G		No	ClinGen gnomAD
CA6849190 rs368918534	2188	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	2190	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6849193 rs766503150	2191	V>L		No	ClinGen ExAC gnomAD
rs757783372 CA6849194	2193	P>A		No	ClinGen ExAC TOPMed
CA6849195 rs79125234	2195	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1384714767 CA387074408	2196	A>S		No	ClinGen TOPMed
rs1164352871 CA387074414	2196	A>V		No	ClinGen TOPMed
rs1555242481 CA387074436	2197	P>L		No	ClinGen Ensembl
rs140880563 CA6849196	2200	I>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA387074751 rs1165491349	2203	M>I		No	ClinGen TOPMed
CA6849222 rs768685653	2203	M>R		No	ClinGen ExAC gnomAD
CA6849221 rs201608746	2203	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA387074800 rs1411599369	2205	L>R		No	ClinGen TOPMed
CA244785827 rs1038106238	2206	S>G		No	ClinGen TOPMed
rs1188715553 CA387074836	2207	G>E		No	ClinGen gnomAD
rs1473725173 CA387074831	2207	G>R		No	ClinGen TOPMed

No associated diseases with P50748

2 regional properties for P50748

Type	Name	Position	InterPro Accession
domain	RZZ complex, subunit KNTC1/ROD, C-terminal	487 - 915	IPR019527-1
domain	RZZ complex, subunit KNTC1/ROD, C-terminal	1581 - 2129	IPR019527-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle	Dynamic pattern of localization during the cell cycle At interphase, uniformly distributed throughout the cytoplasm and nucleus By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
kinetochore microtubule	Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
RZZ complex	A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

1 GO annotations of molecular function

Name	Definition
small GTPase binding	Binding to a small monomeric GTPase.

6 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic sister chromatid segregation	The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
mitotic spindle assembly checkpoint signaling	A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
protein localization to kinetochore involved in kinetochore assembly	Any protein localization to kinetochore that is involved in kinetochore assembly.
protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
regulation of exit from mitosis	Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MWNDIELLTN	DDTGSGYLSV	GSRKEHGTAL	YQVDLLVKIS	SEKASLNPKI	QACSLSDGFI
70	80	90	100	110	120
IVADQSVILL	DSICRSLQLH	LVFDTEVDVV	GLCQEGKFLL	VGERSGNLHL	IHVTSKQTLL
130	140	150	160	170	180
TNAFVQKAND	ENRRTYQNLV	IEKDGSNEGT	YYMLLLTYSG	FFCITNLQLL	KIQQAIENVD
190	200	210	220	230	240
FSTAKKLQGQ	IKSSFISTEN	YHTLGCLSLV	AGDLASEVPV	IIGGTGNCAF	SKWEPDSSKK
250	260	270	280	290	300
GMTVKNLIDA	EIIKGAKKFQ	LIDNLLFVLD	TDNVLSLWDI	YTLTPVWNWP	SLHVEEFLLT
310	320	330	340	350	360
TEADSPSSVT	WQGITNLKLI	ALTASANKKM	KNLMVYSLPT	MEILYSLEVS	SVSSLVQTGI
370	380	390	400	410	420
STDTIYLLEG	VCKNDPKLSE	DSVSVLVLRC	LTEALPENRL	SRLLHKHRFA	EAESFAIQFG
430	440	450	460	470	480
LDVELVYKVK	SNHILEKLAL	SSVDASEQTE	WQQLVDDAKE	NLHKIQDDEF	VVNYCLKAQW
490	500	510	520	530	540
ITYETTQEML	NYAKTRLLKK	EDKTALIYSD	GLKEVLRAHA	KLTTFYGAFG	PEKFSGSSWI
550	560	570	580	590	600
EFLNNEDDLK	DIFLQLKEGN	LVCAQYLWLR	HRANFESRFD	VKMLESLLNS	MSASVSLQKL
610	620	630	640	650	660
CPWFKNDVIP	FVRRTVPEGQ	IILAKWLEQA	ARNLELTDKA	NWPENGLQLA	EIFFTAEKTD
670	680	690	700	710	720
ELGLASSWHW	ISLKDYQNTE	EVCQLRTLVN	NLRELITLHR	KYNCKLALSD	FEKENTTTIV
730	740	750	760	770	780
FRMFDKVLAP	ELIPSILEKF	IRVYMREHDL	QEEELLLLYI	EDLLNRCSSK	STSLFETAWE
790	800	810	820	830	840
AKAMAVIACL	SDTDLIFDAV	LKIMYAAVVP	WSAAVEQLVK	QHLEMDHPKV	KLLQESYKLM
850	860	870	880	890	900
EMKKLLRGYG	IREVNLLNKE	IMRVVRYILK	QDVPSSLEDA	LKVAQAFMLS	DDEIYSLRII
910	920	930	940	950	960
DLIDREQGED	CLLLLKSLPP	AEAEKTAERV	IIWARLALQE	EPDHSKEGKA	WRMSVAKTSV
970	980	990	1000	1010	1020
DILKILCDIQ	KDNLQKKDEC	EEMLKLFKEV	ASLQENFEVF	LSFEDYSNSS	LVADLREQHI
1030	1040	1050	1060	1070	1080
KAHEVAQAKH	KPGSTPEPIA	AEVRSPSMES	KLHRQALALQ	MSKQELEAEL	TLRALKDGNI
1090	1100	1110	1120	1130	1140
KTALKKCSDL	FKYHCNADTG	KLLFLTCQKL	CQMLADNVPV	TVPVGLNLPS	MIHDLASQAA
1150	1160	1170	1180	1190	1200
TICSPDFLLD	ALELCKHTLM	AVELSRQCQM	DDCGILMKAS	FGTHKDPYEE	WSYSDFFSED
1210	1220	1230	1240	1250	1260
GIVLESQMVL	PVIYELISSL	VPLAESKRYP	LESTSLPYCS	LNEGDGLVLP	VINSISALLQ
1270	1280	1290	1300	1310	1320
NLQESSQWEL	ALRFVVGSFG	TCLQHSVSNF	MNATLSEKLF	GETTLVKSRH	VVMELKEKAV
1330	1340	1350	1360	1370	1380
IFIRENATTL	LHKVFNCRLV	DLDLALGYCT	LLPQKDVFEN	LWKLIDKAWQ	NYDKILAISL
1390	1400	1410	1420	1430	1440
VGSELASLYQ	EIEMGLKFRE	LSTDAQWGIR	LGKLGISFQP	VFRQHFLTKK	DLIKALVENI
1450	1460	1470	1480	1490	1500
DMDTSLILEY	CSTFQLDCDA	VLQLFIETLL	HNTNAGQGQG	DASMDSAKRR	HPKLLAKALE
1510	1520	1530	1540	1550	1560
MVPLLTSTKD	LVISLSGILH	KLDPYDYEMI	EVVLKVIERA	DEKITNININ	QALSILKHLK
1570	1580	1590	1600	1610	1620
SYRRISPPVD	LEYQYMLEHV	ITLPSAAQTR	LPFHLIFFGT	AQNFWKILST	ELSEESFPTL
1630	1640	1650	1660	1670	1680
LLISKLMKFS	LDTLYVSTAK	HVFEKKLKPK	LLKLTQAKSS	TLINKEITKI	TQTIESCLLS
1690	1700	1710	1720	1730	1740
IVNPEWAVAI	AISLAQDIPE	GSFKISALKF	CLYLAERWLQ	NIPSQDEKRE	KAEALLKKLH
1750	1760	1770	1780	1790	1800
IQYRRSGTEA	VLIAHKLNTE	EYLRVIGKPA	HLIVSLYEHP	SINQRIQNSS	GTDYPDIHAA
1810	1820	1830	1840	1850	1860
AKEIAEVNEI	NLEKVWDMLL	EKWLCPSTKP	GEKPSELFEL	QEDEALRRVQ	YLLLSRPIDY
1870	1880	1890	1900	1910	1920
SSRMLFVFAT	STTTTLGMHQ	LTFAHRTRAL	QCLFYLADKE	TIESLFKKPI	EEVKSYLRCI
1930	1940	1950	1960	1970	1980
TFLASFETLN	IPITYELFCS	SPKEGMIKGL	WKNHSHESMA	VRLVTELCLE	YKIYDLQLWN
1990	2000	2010	2020	2030	2040
GLLQKLLGFN	MIPYLRKVLK	AISSIHSLWQ	VPYFSKAWQR	VIQIPLLSAS	CPLSPDQLSD
2050	2060	2070	2080	2090	2100
CSESLIAVLE	CPVSGDLDLI	GVARQYIQLE	LPAFALACLM	LMPHSEKRHQ	QIKNFLGSCD
2110	2120	2130	2140	2150	2160
PQVILKQLEE	HMNTGQLAGF	SHQIRSLILN	NIINKKEFGI	LAKTKYFQML	KMHAMNTNNI
2170	2180	2190	2200
TELVNYLAND	LSLDEASVLI	TEYSKHCGKP	VPPDTAPCEI	LKMFLSGLS