P50531

PR
Gene name
rad17 (SPAC14C4.13)
Protein name
Checkpoint protein rad17
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC14C4.13
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50531

Entry ID Method Resolution Chain Position Source
AF-P50531-F1 Predicted AlphaFoldDB

18 variants for P50531

Variant ID(s) Position Change Description Diseaes Association Provenance
I_5253411_G_T 18 K>N No Jeffares_SNPs
I_5253553_G_C 66 E>Q No Jeffares_SNPs
I_5253565_C_A 70 Q>K No Jeffares_SNPs
I_5253677_G_A 93 A>T No Jeffares_SNPs
I_5253906_C_T 150 S>L No Jeffares_SNPs
I_5253980_A_G 175 M>V No Jeffares_SNPs
I_5254015_T_A 186 N>K No Jeffares_SNPs
I_5254079_T_A 208 S>T No Jeffares_SNPs
I_5254457_A_G 334 T>A No Jeffares_SNPs
I_5254733_G_A 426 G>S No Jeffares_SNPs
I_5254776_A_C 440 Q>P No Jeffares_SNPs
I_5254782_A_C 442 N>T No Jeffares_SNPs
I_5254854_A_G 466 K>R No Jeffares_SNPs
I_5254905_G_A 483 S>N No Jeffares_SNPs
I_5255060_T_G 535 F>V No Jeffares_SNPs
I_5255163_T_G 569 I>S No Jeffares_SNPs
I_5255223_C_T 589 A>V No Jeffares_SNPs
I_5255225_C_T 590 H>Y No Jeffares_SNPs

No associated diseases with P50531

1 regional properties for P50531

Type Name Position InterPro Accession
domain AAA+ ATPase domain 104 - 241 IPR003593

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
chromosome, telomeric repeat region A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Rad17 RFC-like complex A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA clamp loader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis.

6 GO annotations of biological process

Name Definition
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint.
mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRRQLSFHES TKRSLKKKKI RKIEKPSLVS KTSRDKNASI TDIHEEDIEA FSDEENKIVH
70 80 90 100 110 120
LNNLKEDRFQ LWFEKYIPQK AADLAVHKSK ISAIKQWMLT DSLESRLLLI CGPSGCGKST
130 140 150 160 170 180
AVQVLAKELG YSLIEWLNPM NLKEPSNQES DTLSLTEKFS RFMSLCETYP ELELMDSNNI
190 200 210 220 230 240
QKRGKNAQGK KKFIFLDEIP HLSKFNGSLD AFRNVIRTAL TSRGAFSIIM VLTEIQLNNL
250 260 270 280 290 300
EGINSQDRNS FNSVQIMGND LLQDPRVTVL QFNPIAPTYM KKCLGSILRK EGVPKSPKLL
310 320 330 340 350 360
SLVENICSAS EGDLRSAINS LQLSISQSFE KKGTKNIREV KEGKGKGNDF SLEAAQVLER
370 380 390 400 410 420
LSKSDSEAYA RFKNYKSAYI PKSDKNENSF FKKDVGLGMM HAIGKVVWNK REGDDEVLKA
430 440 450 460 470 480
SSQQTGNSER IKGVKVSKSQ ENKNCISLKS DQRERMLNVD QCFTSKRRSL VDIESTINQS
490 500 510 520 530 540
GLSGSVFRYG LFENYVDSCV TTDEAFNVCD LLSISDCLSH DFPYSYTGDE ISTWFSVQGT
550 560 570 580 590 600
LFYLPSPVPR KWRQLRFQQW NNEGIVRGIF DDYMVIYGKR SVSDPVIEAH EDQVLEDIDD
PIEDED