P50506

PR
Gene name
HXK
Protein name
Hexokinase
Names
Species
Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
KEGG Pathway
EC number
2.7.1.1: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50506

Entry ID Method Resolution Chain Position Source
AF-P50506-F1 Predicted AlphaFoldDB

No variants for P50506

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50506

No associated diseases with P50506

3 regional properties for P50506

Type Name Position InterPro Accession
binding_site Hexokinase, binding site 152 - 177 IPR019807
domain Hexokinase, N-terminal 28 - 220 IPR022672
domain Hexokinase, C-terminal 226 - 466 IPR022673

Functions

Description
EC Number 2.7.1.1 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fructokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.
glucokinase activity Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.
glucose binding Binding to D- or L-enantiomers of glucose.

3 GO annotations of biological process

Name Definition
cellular glucose homeostasis A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVHLGPKPPQ HRKGSFLDVP EYLLKELTEL EGLLTVSGET LRKITDHFIS ELEKGLSKQG
70 80 90 100 110 120
GNIPMIPGWV MDFPTGKEMG DYLAIDLGGT NLRVVLVKLG GNRDFDTTQS KFALPENMRT
130 140 150 160 170 180
AKSEELWEFI AECLQKFVEE EFRNGVLSNL PLGFTFSYPA SQGSINEGYL QRWTKGFDIE
190 200 210 220 230 240
GVEGHDVVPM LQAAIEKRKV PIEVVALIND TTGTLVASMY TDPEAKMGLF SGTGCNGAYY
250 260 270 280 290 300
DVVDNIPKLE GKVPDDIKSS SPMAINCEYG AFDNEHIILP RTKYDIQIDE ESPRPGQQAF
310 320 330 340 350 360
EKMISGYYLG EVLRLILLDL TSKQLIFKDQ DLSKLQVPFI LDTSIPARIE EDPFENLSDV
370 380 390 400 410 420
QELFQEILGI QTTSPERKII RRLAELIGER SARLSICGIA AICKKRGYKT AHCAADGSVY
430 440 450 460 470
NKYPGFKERA AKGLRDIFQW ESEEDPIVIV PAEDGLGAGA AIIAALTEKR LKDGLPLV