P50482

PR
Gene name
SLC9A2 (NHE2)
Protein name
Sodium/hydrogen exchanger 2
Names
Na(+)/H(+) exchanger 2, NHE-2, Solute carrier family 9 member 2
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

632-706 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50482

Entry ID Method Resolution Chain Position Source
AF-P50482-F1 Predicted AlphaFoldDB

No variants for P50482

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50482

No associated diseases with P50482

2 regional properties for P50482

Type Name Position InterPro Accession
domain Cation/H+ exchanger 84 - 484 IPR006153
domain Sodium/hydrogen exchanger, regulatory region 575 - 683 IPR032103

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

1 GO annotations of biological process

Name Definition
regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESAGTGRSL RTPPPRLLLL LLLQVAGPAG ALAETLLNAP KAMGTSSSPL SPASVVAPGT
70 80 90 100 110 120
TAFEESRLPV FTLDYPHVQI PFEITLWILL ASLAKIGFHL YHKLPTIVPE SCLLIMVGLL
130 140 150 160 170 180
LGGIIFGVDE KSPPAMKTDV FFLYLLPPIV LDAGYFMPTR PFFENLGTIF WYAVVGTLWN
190 200 210 220 230 240
SIGIGVSLFG ICQIEAFGLS DITLLQNLLF GSLISAVDPV AVLAVFENIH VNEQLYILVF
250 260 270 280 290 300
GESLLNDAVT VVLYNLFKSF CQMKTIETID VFAGIANFFV VGIGGVLIGI FLGFIAAFTT
310 320 330 340 350 360
RFTHNIRVIE PLFVFLYSYL SYITAEMFHL SGIMAITACA MTMNKYVEEN VSQKSYTTIK
370 380 390 400 410 420
YFMKMLSSVS ETLIFIFMGV STVGKNHEWN WAFVCFTLAF CLIWRALGVF VLTRVINWFR
430 440 450 460 470 480
TIPLTFKDQF IIAYGGLRGA ICFALVFLLP AAVFPRKKLF ITAAIVVIFF TVFILGITIR
490 500 510 520 530 540
PLVEFLDVKR SNKKQQAVSE EIHCRFFDHV KTGIEDVCGH WGHNFWRDKF KKFDDKYLRK
550 560 570 580 590 600
LLIRENQPKS SIVSLYKKLE IKHAIEMAET GMISTVPSFA SLNDCREEKI RKLTPGEMDE
610 620 630 640 650 660
IREILSRNLY QIRQRTLSYN RHNLTADTSE RQAKEILIRR RHSLRESIRK DNSLNRERRA
670 680 690 700 710 720
STSTSRYLSL PKNTKLPEKL QKRKNISNAD GDSSDSEADA GTTVLNLQPR ARRFLPEPFS
730 740 750 760 770 780
KKASQAYKME WKNEVDAGSG QGQPSPPAAP RSKEGGTQTP AVLRQPLLSK DQGREDSLTE
790 800
GGRPKPPPRL VRRASEPGNR KSRLGSDKP