P50449

PR
Gene name
SERPINE1 (PAI-1, PAI1, PLANH1)
Protein name
Plasminogen activator inhibitor 1
Names
PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1
Species
Neovison vison (American mink) (Mustela vison)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

296-366 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50449

Entry ID Method Resolution Chain Position Source
AF-P50449-F1 Predicted AlphaFoldDB

No variants for P50449

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50449

No associated diseases with P50449

2 regional properties for P50449

Type Name Position InterPro Accession
conserved_site Serpin, conserved site 373 - 383 IPR023795
domain Serpin domain 33 - 400 IPR023796

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

1 GO annotations of biological process

Name Definition
replicative senescence A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQMSTVCLAL GLALVFGEAS ASYLHETRAA ELATDFGVKV FKQVAQASKD RNMVFSPYGL
70 80 90 100 110 120
ASVLAMLQLT TAGETRQQIQ EAMRFQIDEK GMAPALRQLY KELMGPWNKD EISTADAIFV
130 140 150 160 170 180
QRDLKLVHGF MPYFFRLFQT TVKQVDFSEV ERARFIINDW VKRHTKGMIG DLLGRGTVDQ
190 200 210 220 230 240
LTRLMLVNAL YFNGQWKTPF PKSGTHHRLF HKSDGSTVSV PMMAQTNKFN YTEFSTPEGR
250 260 270 280 290 300
YYDILELPYH GDTLSMFIAA PYEKDVPLSA LTNILDAQLI SQWKGNMTRR LRLLVLPKFS
310 320 330 340 350 360
LESEVNLRGP LENLGMTDMF RPNQADFSSL SDQEALYVSQ ALQKVKIEVN ESGTVASSST
370 380 390
AIIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP