P50299

PR
Gene name
SAM1
Protein name
S-adenosylmethionine synthase 1
Names
AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1
Species
Hordeum vulgare (Barley)
KEGG Pathway
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-39 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50299

Entry ID Method Resolution Chain Position Source
AF-P50299-F1 Predicted AlphaFoldDB

No variants for P50299

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50299

No associated diseases with P50299

5 regional properties for P50299

Type Name Position InterPro Accession
domain S-adenosylmethionine synthetase, N-terminal 6 - 103 IPR022628
domain S-adenosylmethionine synthetase, central domain 119 - 240 IPR022629
domain S-adenosylmethionine synthetase, C-terminal 242 - 382 IPR022630
conserved_site S-adenosylmethionine synthetase, conserved site 121 - 131 IPR022631-1
conserved_site S-adenosylmethionine synthetase, conserved site 268 - 276 IPR022631-2

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

2 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAETFLFTS ESVNEGHPDK LCDQVSDAVL DACLAQDPDS KVACETCTKT NMVMVFGEIT
70 80 90 100 110 120
TKATVDYEKI VRDTCRDIGF ISDDVGLDAD HCKVLVNIEQ QSPDIAQGVH GHFTKRPEEV
130 140 150 160 170 180
GAGDQGIMFG YATDETPELM PLTHMLATKL GARLTEVRKN GTCAWLRPDG KTQVTIEYLN
190 200 210 220 230 240
EGGAMVPVRV HTVLISTQHD ETVTNDEIAA DLKEHVIKPV IPGKYLDENT IFHLNPSGRF
250 260 270 280 290 300
VIGGPHGDAG LTARKIIIDT YGGWGAHGGG AFSGKDPTKV DRSGAYIARQ AAKSIIASGL
310 320 330 340 350 360
ARRCIVQISY AIGVPEPLSV FVDSYGTGKI PDREILKLVK ENFDFRPGMI TINLDLKKGG
370 380 390
NRFIKTAAYG HFGRDDADFT WEVVKPLKFD KASA