P50028

PR
Gene name
parE (gyrB)
Protein name
DNA topoisomerase 4 subunit B
Names
Topoisomerase IV subunit B
Species
Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)
KEGG Pathway
mcp:MCAP_0457
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

350-467 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50028

Entry ID Method Resolution Chain Position Source
AF-P50028-F1 Predicted AlphaFoldDB

No variants for P50028

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50028

No associated diseases with P50028

5 regional properties for P50028

Type Name Position InterPro Accession
domain DNA gyrase B subunit, C-terminal 563 - 624 IPR002288
domain Histidine kinase/HSP90-like ATPase 32 - 176 IPR003594
domain TOPRIM domain 420 - 534 IPR006171
domain DNA topoisomerase, type IIA, subunit B, domain 2 221 - 390 IPR013506
conserved_site DNA topoisomerase, type IIA, conserved site 424 - 432 IPR018522

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAENKKYDES AIQVLEGLEA VRKRPGMYIG STDNKGLHHL VWEIVDNAID EALAGYCTQI
70 80 90 100 110 120
DVILEKDNSI TVIDNGRGIP TGMHKTGKPT PEVIFSVLHA GGKFDSTAYK SSGGLHGVGS
130 140 150 160 170 180
SVTNALSKRF KAIIYRDKKI HEIEFKNGGK LEKPLTFINT TYKTGTTINF LPDDTIFSNA
190 200 210 220 230 240
KFNFSLISER LKESALLNSG LKITLSDLIS NRYVEYQFQD GLVEFVKELV DDKTPVTDII
250 260 270 280 290 300
TINNESKNII VEIALQYTED DNEIILGFAN NVKTIDGGTH LVGFKSGLIR AINDYAKDQK
310 320 330 340 350 360
ILKDKTKLDS NDLREGLVAI VTVKIPENLI EYEGQTKSKL GTSDAKTVVE QIVYEFMSYW
370 380 390 400 410 420
LIENKVLANK VIENALNAQK ARIAAKQARQ AIKSVKGKKN VNKLMLGKLT PAQGKKRELN
430 440 450 460 470 480
ELYLVEGDSA GGSAKSGRDR NFQAILPLRG KVINSEKAKL VDLLKNEEIQ SIINAIGAGV
490 500 510 520 530 540
GKDFDISDIN YGKIIIMTDA DTDGAHIQTL LLTFFYRHMK DLIIHKKVYI ALPPLYKITF
550 560 570 580 590 600
NDKSFIYLWD EEELNKFNKT NTKKYEIQRY KGLGEMNADQ LWQTTMDPKN RKIIQVTISD
610 620 630 640
GLLAERMFKT LMGDDVEKRK LWIQENVKFT LEDDQIQIIE MEK