P49958

PR
Gene name
dph-1 (C14B1.5)
Protein name
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Names
Diphthamide biosynthesis protein 1, Diphtheria toxin resistance protein 1, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C14B1.5
EC number
2.5.1.108: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

340-396 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49958

Entry ID Method Resolution Chain Position Source
AF-P49958-F1 Predicted AlphaFoldDB

No variants for P49958

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49958

No associated diseases with P49958

No regional properties for P49958

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P49958

Functions

Description
EC Number 2.5.1.108 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine- = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.

1 GO annotations of biological process

Name Definition
peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATRATQIST LVEEIANNPN LKEDLKILPS NYTFEVPKTI WKIRSTESKY VALQFPEGLI
70 80 90 100 110 120
MYACVIADIL EKYTGCDTVI MGDVTYGACC VDDYTAKSMG CDLLVHYGHS CLVPIQNTDG
130 140 150 160 170 180
IAMLYVFVNI HINLSHLIDC VKENFQGKRL VVVSTVQFIP SLQTLRTTFN KDDSSIRIDI
190 200 210 220 230 240
PQCKPLSPGE VLGCTSPRLD ASKYDAIVYL GDGRFHLESI MIHNPEIEAF QYDPYSRKLT
250 260 270 280 290 300
REFYDHDLMR KNRIGSIEIA RKCTTFGLIQ GTLGRQGNLK VVEELEAQLE RKGKKFLRVL
310 320 330 340 350 360
LSEIFPEKLA MFPEVDCWVQ VACPRLSIDW GTQFPKPLLY PFELAVALDN ISVPSDHWPM
370 380 390
DYYSNDSLGP WTNNNEANRP KREKRKPHIV VRTEAS