P49887

PR
Gene name
SULT1E1 (EST)
Protein name
Sulfotransferase 1E1
Names
ST1E1, Estrogen sulfotransferase, ST1E3, Sulfotransferase, estrogen-preferring
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
cpoc:100135625
EC number
2.8.2.4: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

202-281 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49887

Entry ID Method Resolution Chain Position Source
AF-P49887-F1 Predicted AlphaFoldDB

No variants for P49887

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49887

No associated diseases with P49887

1 regional properties for P49887

Type Name Position InterPro Accession
domain Sulfotransferase domain 39 - 288 IPR000863

Functions

Description
EC Number 2.8.2.4 Sulfotransferases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

4 GO annotations of molecular function

Name Definition
estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate.

6 GO annotations of biological process

Name Definition
3'-phosphoadenosine 5'-phosphosulfate metabolic process The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
estrogen catabolic process The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
ethanol catabolic process The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
sulfation The addition of a sulfate group to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMDSSEHDYY EYFDEFRGIL LYKQFIKYWD NVEAFQARPD DLVIAAYPKS GTTWISEVVC
70 80 90 100 110 120
MIYAEGDVKK CRQDAIFNRV PFLECRNDKM MNGVKQLEEM NSPRIIKTHL PPRLLPASFW
130 140 150 160 170 180
EKRCKMICIC RNAKDVAVSY YYFFLMVANH PDPGSFPEFV EKFMQGQVPY GSWYDHVKSW
190 200 210 220 230 240
WEKSTDPRIL FIFYEDMKED IRKEVLKLIH FLGRKPSEEL VDKIIKHTSF QEMKNNPSTN
250 260 270 280 290
YTMLPEEIMN QKVSPFMRKG ISGDWKNHFT VALNESFDKH YQQQMKGSTL QLRTEI