Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P49696
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P49696-F1 | Predicted | AlphaFoldDB |
No variants for P49696
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P49696 | |||||
No associated diseases with P49696
6 regional properties for P49696
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 293 - 304 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 258 - 886 | IPR002300 |
| domain | Glutathione S-transferase, C-terminal | 48 - 137 | IPR004046 |
| domain | Glutathione S-transferase, C-terminal-like | 27 - 155 | IPR010987 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 931 - 1083 | IPR013155 |
| domain | Valyl tRNA synthetase, anticodon-binding domain | 885 - 1027 | IPR033705 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| valine-tRNA ligase activity | Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| valyl-tRNA aminoacylation | The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLYVSPHL | DDFRSLLALV | AAEYCGNAKQ | QSQVWQWLSF | ADNELTPVSC | AVVFPLMGMT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLDKKIQQNS | RVELMRVLKV | LDQALEPRTF | LVGESITLAD | MAVAMAVLLP | FKYVLEPSDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NVLMNVTRWF | TTCINQPEFL | KVLGKISLCE | KMVPVTAKTS | TEEAAAVHPD | AAALNGPPKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EAQLKKEAKK | REKLEKFQQK | KEMEAKKKMQ | PVAEKKAKPE | KRELGVITYD | IPTPSGEKKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVSPLPDSYS | PQYVEAAWYP | WWEKQGFFKP | EFGRKSIGEQ | NPRGIFMMCI | PPPNVTGSLH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGHALTNAIQ | DTLTRWHRMR | GETTLWNPGC | DHAGIATQVV | VEKKLMREKG | TSRHDLGREK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FIEEVWKWKN | EKGDRIYHQL | KKLGSSLDWD | RACFTMDPKL | SYAVQEAFIR | MHDEGVIYRS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KRLVNWSCSL | NSAISDIEVD | KNELSGRTLL | PVPGYKEKVE | FGVLVSFAYK | VDGSDEEVVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ATTRIETMLG | DTAVAVHPSD | SRYQHLKGKT | VLHPFCDRKI | PVVFDDFVDM | SFGTGAVKIT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PAHDHNDYEV | GVRHNLAFIN | ILDENGFVIN | VPPPFLGMKR | FDARKAVLQA | LKDRDQFKEI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KDNPMVVPVC | SRSKDIVEPL | MKPQWYVSCS | DMGKQAADAV | REGRLKIIPD | HHSQTWFNWM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DNIRDWCISR | QLWWGHRIPA | YFITVSDPSV | KPGEDMDGHY | RVSGRTPEEA | REKAAKRFNV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SPDKIALRQD | EDVLDTWFSS | GINPFSILGW | PNETEDLNVF | YPGTLLETGH | DILFFWVARM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VMMGLKLTGK | LPFKEVYHCA | VVRDAHGRKM | SKSLGNVIDP | LDDHIGIALE | GLHAQLMDTN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LDPLEVEKPK | KVQKADYPNC | IPECGTDALR | FALCAYTSQG | RDINLDVNRI | LGYRHFCNKL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WNAVKFAMRT | LGDQFVPADT | SPAEREESVS | DRWILSRLST | AVAQCDAAFR | TYDFPAITTA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| IYNFWLYELC | DVYLESVKPV | FIKAKEDGSC | ERPAAVCRQT | LYTCLEVGLR | LLAPLMPFVT |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EELYQRLPRR | RPQSDPPSIC | VTPYPDAAEF | CWQCEDVDRD | IDFIMGVVRT | IRSLRSDYKL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TKTAADCYLQ | CTDAATVSLV | QKYSLQIQTL | SYSQAIVPLM | APQPAPEGCA | VAIASDRCTV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NMMLKGLIDV | EKEVPKLMGK | KTDLEKQIEK | LSEKISKGDY | KEKVPVKVQE | QDTEKLRQSQ |
| 1210 | |||||
| TELEKVKEAM | DNFQKMM |