P49695

PR
Gene name
pkwA (pkw1)
Protein name
Probable serine/threonine-protein kinase PkwA
Names
Species
Thermomonospora curvata
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

150-482 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

154-178 (Activation loop from InterPro)

Target domain

16-266 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for P49695

Entry ID Method Resolution Chain Position Source
5YZV X-ray 260 A A/B/C/D/E 441-742 PDB
AF-P49695-F1 Predicted AlphaFoldDB

No variants for P49695

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49695

No associated diseases with P49695

11 regional properties for P49695

Type Name Position InterPro Accession
domain Protein kinase domain 16 - 266 IPR000719
repeat WD40 repeat 449 - 742 IPR001680
active_site Serine/threonine-protein kinase, active site 134 - 146 IPR008271
binding_site Protein kinase, ATP binding site 22 - 44 IPR017441
conserved_site WD40 repeat, conserved site 516 - 530 IPR019775-1
conserved_site WD40 repeat, conserved site 558 - 572 IPR019775-2
conserved_site WD40 repeat, conserved site 600 - 614 IPR019775-3
conserved_site WD40 repeat, conserved site 683 - 697 IPR019775-4
repeat G-protein beta WD-40 repeat 516 - 530 IPR020472-1
repeat G-protein beta WD-40 repeat 600 - 614 IPR020472-2
repeat G-protein beta WD-40 repeat 683 - 697 IPR020472-3

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEPLQPGDP GRIGPYRLVS RLGAGGMGQV FLARSPGGRP VVVKVILPEY ANDDEYRIRF
70 80 90 100 110 120
AREVEAARRV GGFHTAQVID ADPTADPPWM ATAYIPGPSL RKAVTERGPL YGNNLRTLAA
130 140 150 160 170 180
GLVEGLAAIH ACGLVHRDFK PSNIVLAADG PRVIDFGVAR PLDSSVMTQS GAVIGTLAYM
190 200 210 220 230 240
SPEQTDGSQV GPASDVFSLG TVLAFAATGR SPFMADSIGE IIARISGPPP ELPELPDDLR
250 260 270 280 290 300
ELVYACWEQN PDLRPTTAEL LAQLSTDHTG DDWPPPHLSD LIGSMLPLGA TTSPNPSLAI
310 320 330 340 350 360
EPPPPSHGPP RPSEPLPDPG DDADEPSAEK PSRTLPEPEP PELEEKPIQV IHEPERPAPT
370 380 390 400 410 420
PPRPREPARG AIKPKNPRPA APQPPWSPPR VQPPRWKQLI TKKPVAGILT AVATAGLVVS
430 440 450 460 470 480
FLVWQWTLPE TPLRPDSSTA PSESADPHEL NEPRILTTDR EAVAVAFSPG GSLLAGGSGD
490 500 510 520 530 540
KLIHVWDVAS GDELHTLEGH TDWVRAVAFS PDGALLASGS DDATVRLWDV AAAEERAVFE
550 560 570 580 590 600
GHTHYVLDIA FSPDGSMVAS GSRDGTARLW NVATGTEHAV LKGHTDYVYA VAFSPDGSMV
610 620 630 640 650 660
ASGSRDGTIR LWDVATGKER DVLQAPAENV VSLAFSPDGS MLVHGSDSTV HLWDVASGEA
670 680 690 700 710 720
LHTFEGHTDW VRAVAFSPDG ALLASGSDDR TIRLWDVAAQ EEHTTLEGHT EPVHSVAFHP
730 740
EGTTLASASE DGTIRIWPIA TE