P49381

PR
Gene name
NTH1
Protein name
Cytosolic neutral trehalase
Names
Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase, KlNTH1
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_E17271g
EC number
3.2.1.28: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49381

Entry ID Method Resolution Chain Position Source
AF-P49381-F1 Predicted AlphaFoldDB

No variants for P49381

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49381

No associated diseases with P49381

3 regional properties for P49381

Type Name Position InterPro Accession
domain Neutral trehalase Ca2+ binding 109 - 138 IPR011120
conserved_site Glycoside hydrolase, family 37, conserved site 302 - 315 IPR018232-1
conserved_site Glycoside hydrolase, family 37, conserved site 625 - 634 IPR018232-2

Functions

Description
EC Number 3.2.1.28 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
calcium ion binding Binding to a calcium ion (Ca2+).

1 GO annotations of biological process

Name Definition
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGKVNNNPP RSRHRRTSSL EEVVDPFSTP DVYYGPKSDP SKLLSKNRFT RTRTFSVAEP
70 80 90 100 110 120
GGGKGHSSSY TSPYFDTTVP LRRRGSEDDS YSASQGQRRF YIEDVDKTLK ELLASEDTDG
130 140 150 160 170 180
NYQITIEDTG PKVIRVGTVN SNGYKHVHIR GTYMLSNLLQ ELTLAKLFNR KQVILDEARL
190 200 210 220 230 240
NENPVNRMTR LISGQFWKSL TRRIDSNNIA KIAYDTKIDT PKAKNPRIYV PYNCQDEYQQ
250 260 270 280 290 300
LVQWSEMDPS LQLEVNYLPK DITPEFVKSL NDKPGLLCLA MESHMDPVTG EETWVGFPYA
310 320 330 340 350 360
VPGGRFNELY GWDSYFMALG LLESNKLDVA RGMVEHFIFE IDHYGKILNA NRSYYLCRSQ
370 380 390 400 410 420
PPFLTDMALQ VCRKMGGDKN PVAVDLLRRA FKAAIKEYLT VWTASPRLDE KTGLSCYHPD
430 440 450 460 470 480
GIGIPPETEP GHFDSILRKY AEKYNVSIPE FRDLYNSQKV HEPDLDVFFL HDRGVRESGH
490 500 510 520 530 540
DTTYRFENVC AYLATIDLNS LLYKYEVDIA YVIKKYFGDN FEGLPEGHRT SNDWEKLAEV
550 560 570 580 590 600
RKERIDKYLW DEETGFYYDY NVKTEKRTSY ESVTTFWALW AGMSSQEQAQ RMVENALPKL
610 620 630 640 650 660
EEFGGLVACT ARSRGELSLD RPTRQWDYPF GWAPHQILVW DGLVRYGYEN HTRRLAYRWL
670 680 690 700 710 720
FLMTKAFVDY NGIVVEKYDV TRGTDPHRVD AEYGNQGADF KGVATEGFGW VNSSYLLGMK
730 740 750
YMNNFARRAL GTCVTPKVFF GRLPPKEKKK YGLE