P49373

PR
Gene name
tfs1 (SPAC20H4.03c)
Protein name
Transcription elongation factor S-II
Names
Allergen Ves v I, Hya A, Allergen Ves v II, Hyaluronoglucosaminidase A, Hya, Allergen Dol m II, Hyaluronoglucosaminidase, Allergen Api g 1.0101, Allergen Api g I, TFIIS
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC20H4.03c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-136 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49373

Entry ID Method Resolution Chain Position Source
AF-P49373-F1 Predicted AlphaFoldDB

2 variants for P49373

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2115975_G_A 59 P>S No Jeffares_SNPs
I_2115552_C_T 200 A>T No Jeffares_SNPs

No associated diseases with P49373

4 regional properties for P49373

Type Name Position InterPro Accession
domain Zinc finger, TFIIS-type 251 - 292 IPR001222
domain Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type 6 - 80 IPR003617
domain Transcription elongation factor S-II, central domain 129 - 248 IPR003618
domain Transcription factor IIS, N-terminal 4 - 81 IPR017923

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
RNA polymerase II complex recruiting activity Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
transcription elongation factor activity A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
regulation of mRNA 3'-end processing Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
transcription antitermination Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s).
transcription elongation by RNA polymerase I The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSADIRSAK AALEKAIQGK NIETIINIMT RLKNEVVATE ELLKETRLGL VVGKLRSHPN
70 80 90 100 110 120
EKVGEQAREI VKKWKADVSK GRPLKTTTTT SSTPSKHADV GSQAQKQVQK QSSSGQRTFK
130 140 150 160 170 180
SDNVNVNVTD DKIRNNCIGL MYNALVIDSD ESSSLIIAKA KEIDAQVLAR AAGKTGSEYR
190 200 210 220 230 240
NRMRSLYMNL KDKNNPKLRA SVLRNEITPQ RLSTMTSAEL ASEDRRKEDA KLEQENLFHA
250 260 270 280 290
QGAKPQKAVT DLFTCGKCKQ KKVSYYQMQT RSADEPMTTF CECTVCGNRW KFS